Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention

Abstract

Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling. results: We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group. conclusions: After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype.

Association of polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B with type 2 diabetes mellitus in the Russian population

“…An increase in body mass index (BMI) and fat mass contributes to the development and aggravation of immune resistance (Kloting et al, 2008; Gerken et al, 2007). Recent population studies have demonstrated that people who are homozygous for allele A of the FTO gene variant rs9939609 have a higher BMI, weigh 3 kg more on average and are twice as likely to become obese compared to individuals homozygous for the protective allele T/T genotype (De Luis et al, 2016; Livingstone et al, 2016; Munoz-Yanez et al, 2016; Moraes et al, 2016; Chen et al, 2017). The presence of the protective T allele leads to increased lipolytic activity of adipocytes, thus reducing fat mass (Wahlen, Sjolin & Hoffstedt, 2008).…”

A fat mass and obesity-associated gene polymorphism influences fat mass in exercise-trained individuals

“…Previous work has shown that exercise intervention can ameliorate the influence of FTO risky alleles on BMI on the FTO rs8050136 SNP [ 8 , 9 ] and the rs9939609 SNP [ 10 – 12 ]. However, due to the direct influence of the FTO SNP rs1421085 on early adipocyte differentiation, the effect of exercise training on body fat in the risky allele carriers of the rs1421085 SNP are less certain.…”

Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents

“…Hardy-Weinberg's equilibrium was tested for the rs9939609 polymorphism using the same statistical software (p ¼ 0.356). Moraes et al 28 described the genotype distribution and allele frequency of the rs9939609 polymorphism in EG and CG.…”

“…Similar to our study, they also did not find statistical significance when comparing the AA/ AT and TT genotypes after the intervention. 28 A study with 136 overweight/obese children and adolescents and 172 normal weight subjects observed that after a 12-week program of physical exercises (aerobic, high-intensity interval training, combined training, and walking in water), FTO rs9939609 gene alleles did not show interaction with changes in anthropometric parameters. 29 As well as in our study, a study with a subset of 207 overweight and obese individuals (94 males, mean age 10.79 AE 2.52 years) performed in Germany reported that after an intervention program based on physical exercises and nutritional education and behavioral therapy (individual psychological care of the child/adolescent and his or her family), there was no association of the FTO rs9939609 gene alleles with weight loss, fasting glucose, TG, and LDL and HDL cholesterol.…”