Gene-Gene Interplay and Gene-Diet Interactions Involving the <b><i>MTNR1B </i></b>rs10830963 Variant with Body Weight Loss

Abstract

Background/Aims: Investigation of the genetic makeup may facilitate the implementation of more personalized nutritional interventions. The aims were to examine whether the rs10830963 MTNR1B polymorphism affects weight loss in response to a hypocaloric diet and to find potential gene-gene interplays and gene-diet interactions. Methods: 167 subjects enrolled in a personalized nutritional intervention for weight loss (3-6 weeks) were examined for anthropometric measurements, dietary habits and physical activity at baseline and at the first follow-up visit. Three polymorphisms, which have previously been associated with body weight regulation, rs10830963 (MTNR1B), rs9939609 (FTO) and rs17782313 (MC4R), were analyzed using the Luminex® 100/200™ System. Results: After adjusting for covariates, females with the rs10830963 CG/GG genotype showed lower weight loss than those with the CC genotype. In the total population, carriers of variant alleles of both FTO and MC4R showed a significant association with MTNR1B and weight loss outcome. Moreover, among women, higher total protein and animal protein intakes were associated with a lower weight loss in G allele carriers of the MTNR1B variant. Conclusions: Our data evidenced that rs10830963 MTNR1B polymorphism could be associated with individual differences in weight loss induced by a hypocaloric diet. This association was influenced by FTO and MC4R loci and modified by baseline protein intake.

Future Perspectives of Personalized Weight Loss Interventions Based on Nutrigenetic, Epigenetic, and Metagenomic Data

“…However, a limited number of studies have analyzed the association between melatonin-related genes and body weight loss. In contrast to 2 previous studies, our group observed an association between the rs10830963 genetic variant near melatonin receptor 1B (MTNR1B) and body weight loss in a shortterm weight loss intervention in women (22)(23)(24). On the other hand, the rs12452844 polymorphism of the aralkylamine N-acetyltransferase (AANAT) gene has been associated with 1 y weight change (25).…”

Obesity‐related genetic polymorphisms and adiposity indices in a young Italian population

“…Even if a possible interaction among ACE , MC4R , FTO and PPARG genes can be inferred by GWASs, which supported their relation with obesity and overweight, previous investigations did not test the presence of synergistic effects using a targeted approach. However, it should be mentioned that several studies have been conducted on this topic; a longitudinal study from Bouwman et al reported that adult men carrying FTO rs9939609 T/T genotype + ACE rs4646994‐D allele were protected against weight gain over a 10‐year period; Lazopoulou et al showed a cumulative effect of the presence of FTO rs9939609‐A allele and MC4R rs17782313‐C allele on childhood obesity in a Greek population; Goni et al showed that carrying unfavorable genotypes at both FTO rs9939609 and MC4R rs17782313 loci can influence weight loss in response to a hypocaloric diet; Carlos et al failed to prove the interaction of FTO rs9939609 and PPARG rs1801282 with obesity in Portuguese women; Passaro et al demonstrated a gene–gene interaction between PPARG rs1801282 and ACE rs4646994 on BMI and fat mass.…”

Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes

“…Interestingly, the rs10830963 associates with the outcome of an intervention that targets weight loss [10]. The mechanism linking risk allele presence with intervention failure has yet to be determined.…”