“…However, all of these genes function essentially as reciprocally controlling transcription factors, and in many cases the expression of these genes is monitored by the modulation of many "noncircadian" proteins as readouts. Enzymes regulating cardiac metabolism (57), reactivity of vascular endothelial cells (22,50,54), modulation of inflammatory responses (3,27,33,34,44), bone marrow progenitor cell release (2), and apoptosis (25) all have circadian gene components of control, and all are associated with the myocardial response to coronary artery occlusion. However, the specific relationship between a circadian gene and the inflammatory response and injury associated with early MI has not been determined.…”