Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans

Ackermann, Katrin; Plomp, R; Lao, Oscar; Middleton, Benita; Revell, Victoria L.; Skene, Debra J.; Kayser, Manfred

doi:10.3109/07420528.2013.784773

Cited by 87 publications

(78 citation statements)

References 39 publications

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“…A few hours of sleep deprivation significantly advances the activity onset of hamsters (Antle & Mistlberger, 2000). In humans, BMAL1 is suppressed and melatonin increased in response to sleep deprivation (K. Ackermann et al, 2013;Goh, Tong, Lim, Low, & Lee, 2001). In human subjects, performance and temperature rhythms are altered after one night of total or partial sleep deprivation (Edwards & Waterhouse, 2009;Souissi et al, 2008).…”

Section: Sleep/wake Manipulationmentioning

confidence: 99%

The role of the circadian clock in animal models of mood disorders.

Landgraf¹,

McCarthy²,

Welsh³

2014

Behavioral Neuroscience

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An association between circadian clock function and mood regulation is well established and has been proposed as a factor in the development of mood disorders. Patients with depression or mania suffer disturbed sleep–wake cycles and altered rhythms in daily activities. Environmentally disrupted circadian rhythms increase the risk of mood disorders in the general population. However, proof that a disturbance of circadian rhythms is causally involved in the development of psychiatric disorders remains elusive. Using clock gene mutants, manipulations of sleep–wake and light–dark cycles, and brain lesions affecting clock function, animal models have been developed to investigate whether circadian rhythm disruptions alter mood. In this review, selected animal models are examined to address the issue of causality between circadian rhythms and affective behavior.

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Section: Sleep/wake Manipulationmentioning

confidence: 99%

The role of the circadian clock in animal models of mood disorders.

Landgraf¹,

McCarthy²,

Welsh³

2014

Behavioral Neuroscience

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“…The underlying mechanisms linking metabolic disease, circadian clock misalignment, and sleep restriction are the subject of current research, elucidation of which will require a global "systems" approach (9). Transcriptomic studies have shown that rhythmic gene expression may be affected by sleep restriction, sleep deprivation, and mistimed sleep (10)(11)(12), but, as yet, no studies have directly investigated the effect that sleep and sleep deprivation may have on the metabolic profile. Metabolic profiling, or "metabolomics," is the profiling of small-molecule metabolites and offers the potential to characterize specific metabolic phenotypes associated with disrupted circadian timing and sleep loss.…”

mentioning

confidence: 99%

Effect of sleep deprivation on the human metabolome

Davies

Ang

Revell

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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425

371

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Sleep restriction and circadian clock disruption are associated with metabolic disorders such as obesity, insulin resistance, and diabetes. The metabolic pathways involved in human sleep, however, have yet to be investigated with the use of a metabolomics approach. Here we have used untargeted and targeted liquid chromatography (LC)/MS metabolomics to examine the effect of acute sleep deprivation on plasma metabolite rhythms. Twelve healthy young male subjects remained in controlled laboratory conditions with respect to environmental light, sleep, meals, and posture during a 24-h wake/ sleep cycle, followed by 24 h of wakefulness. Two-hourly plasma samples collected over the 48 h period were analyzed by LC/MS. Principal component analysis revealed a clear time of day variation with a significant cosine fit during the wake/sleep cycle and during 24 h of wakefulness in untargeted and targeted analysis. Of 171 metabolites quantified, daily rhythms were observed in the majority (n = 109), with 78 of these maintaining their rhythmicity during 24 h of wakefulness, most with reduced amplitude (n = 66). During sleep deprivation, 27 metabolites (tryptophan, serotonin, taurine, 8 acylcarnitines, 13 glycerophospholipids, and 3 sphingolipids) exhibited significantly increased levels compared with during sleep. The increased levels of serotonin, tryptophan, and taurine may explain the antidepressive effect of acute sleep deprivation and deserve further study. This report, to our knowledge the first of metabolic profiling during sleep and sleep deprivation and characterization of 24 h rhythms under these conditions, offers a novel view of human sleep/wake regulation.circadian rhythms | total sleep deprivation | melatonin | depression | biomarker C ircadian clocks control the timing of most daily biological processes, including cyclic changes in metabolism and the sleep/wake cycle (1). There is a clear link between the circadian timing system and metabolism (2-4), with disrupted circadian rhythms, sleep restriction, and sleep deprivation associated with metabolic disorders (obesity, insulin resistance, diabetes) and cardiovascular disease (5-8). The underlying mechanisms linking metabolic disease, circadian clock misalignment, and sleep restriction are the subject of current research, elucidation of which will require a global "systems" approach (9). Transcriptomic studies have shown that rhythmic gene expression may be affected by sleep restriction, sleep deprivation, and mistimed sleep (10-12), but, as yet, no studies have directly investigated the effect that sleep and sleep deprivation may have on the metabolic profile. Metabolic profiling, or "metabolomics," is the profiling of small-molecule metabolites and offers the potential to characterize specific metabolic phenotypes associated with disrupted circadian timing and sleep loss. Metabolomics has an advantage over other "omics" techniques, in that it directly samples the metabolic changes in an organism and integrates information from changes at the gene, transcript, an...

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“…In a clinical trial, PD patients that were given melatonin showed a minimal improvement in sleep disorders, with no adverse effect resulted from the treatment [54]. Other studies also indicated that melatonin administration resulted in restoration in daily rhythm of various clock genes expression, hence resetting the disturbed circadian pacemaker [55]. Morover, agomelatine, an antidepressant that produces melatonergic effects shows promising results in treating a variety of sleep disorders in PD [56].…”

Section: Melatonin Regulates Circadian Rhythm In Pdmentioning

confidence: 99%

The Roles of Melatonin in Parkinson’s Disease: An Overview

Moi¹,

Lim²,

Koh³

et al. 2017

SDRP-JCMP

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When the central nervous system loses its nerve cell functions over a period of time, symptoms and problems arise leading to the progression of neurodegenerative diseases. Statistical data shows that more than 5 million people worldwide are affected by Parkinson's disease [PD], and the data is undesirably rising every year. In PD patients, structural and functional changes are shown in the brain, especially the substantia nigra region. The underlying cause that correspond to the development of PD remains unclear. Nevertheless, α-synuclein aggregation has been reported to be neuropathologically linked to PD. On the other hand, several evidences successfully demonstrate the importance and significance of mitochondrial dysfunction in PD models. Treatments available for PD are limited. Recently, as shown in some studies, the antioxidant properties and hypnotic benefits of melatonin bring remarkable contribution to the PD patients. Hence, in this article, we focus on the effect of melatonin associating with the pathology and physiology of PD.

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Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans

Cited by 87 publications

References 39 publications

The role of the circadian clock in animal models of mood disorders.

The role of the circadian clock in animal models of mood disorders.

Effect of sleep deprivation on the human metabolome

The Roles of Melatonin in Parkinson’s Disease: An Overview

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