Four new coumarins from the leaves of Calophyllum inophyllum

<i>In vitro</i> growth-inhibitory activity of <i>Calophyllum inophyllum</i> ethanol leaf extract against diarrhoea-causing bacteria

“…As far as the chemical constituents responsible for antibacterial action of the extract are concerned, various classes of secondary metabolites such as coumarins, flavonoids, triterpenes, and xanthones have previously been identified as the main bioactive constituents of the plant [19]. For example, Yimdjo et al [20] described antibacterial effect of some calophyllic acid, phenylcoumarine, and xanthone derivatives isolated from root bark and seed against S. aureus, whereas calophyllolide was a compound with the highest activity.…”

Calophyllum inophyllum: Beneficial Phytochemicals, Their Uses, and Identification

“…Various xanthone compounds can be isolated from C. inophyllum leaves, such as caloxanthone A, caloxanthone B, caloxanthone C, maclura xanthones, inoxanthone, calophynic acid, 3,4-dihydroxy xanthones [4,12,19], brasilixanthone B, buchanaxanthone [20], inophyxanthone A, pancixanthone A, gerontoxanthone B, jacareubin, pyranojacaereubin, 2-hydroxy xanthone, 4-hydroxyxanthone, 1,3,5-trihydroxy-2-methoxyxanthone, and xanthones [21,22].…”

Chemical Constituents from the Root Bark of Calophyllum inophyllum

“…Cytotoxicity assay: All isolated compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) were evaluated for their in vitro cytotoxic activities against the KB (epidermoid carcinoma) and HeLa S-3 (cervix adenocarcinoma) human cancer cell lines using the MTT colorimetric method [11]. Adriamycin was used as the reference substance.…”

“…Calophyllum inophyllum Linn. (Guttiferae), is a large evergreen plant and commonly found in the tropical regions of the eastern hemisphere [1]. Several coumarins [2][3][4], xanthones [5,6], flavonoids [7] and triterpenes [8] have also been isolated from this plant.…”

“…(Guttiferae), is a large evergreen plant and commonly found in the tropical regions of the eastern hemisphere [1]. Several coumarins [2][3][4], xanthones [5,6], flavonoids [7] and triterpenes [8] have also been isolated from this plant. In the course of our searching for new cytotoxic agents from Thai medicinal plants [9][10][11], a new compound, caloinophyllin B (1) (Figure 1A), along with one known chromanone derivative, caloinophyllin A (2), two known flavonoids, 3,3',4',5,7pentamethoxyflavone (3) [12] and 5,7,4'-trimethoxyflavone (4) [7], and fourteen known xanthones (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), 1,5-dihydroxy-xanthone (5) [13], 1,8-dimethoxyxanthone (6), caloxanthone B (7) [14], 1,6dihydroxy-7-methoxyxanthone (8) [15] 4-hydroxy-xanthone (9) [16], 2-hydroxyxanthone (10) [17], 3-hydroxy-4-methoxyxanthone (11) [18], 3-hydroxy-2-methoxyxanthone (12) [19], 2,3dimethoxyxanthone (13) [20], 1,6-dihydroxyxanthone ( 14) [21], 1,7-dihydroxyxanthone (15) [22], 1,3,5-trihydroxyxanthone ( 16…”