&lt;i&gt;In vitro&lt;/i&gt; growth-inhibitory activity of &lt;i&gt;Calophyllum inophyllum&lt;/i&gt; ethanol leaf extract against diarrhoea-causing bacteria

Kudera, Tomas; Rondevaldova, Johana; Kant, Rashmi; Umar, Mohammed; Skřivanová, E.; Kokoška, Ladislav

doi:10.4314/tjpr.v16i9.23

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…The antibacterial (against Bacillus cereus, B. pumilius, B. subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Staphylocossus aureus and Vibrio cholerae) and antifungal (against Alternaria tenuissima, Aspergillus fumigatus, Aspergillus niger, Candida albicans and Candida tropicalis) properties of Calophyllum species and their bioactive secondary metabolites, including calanolides, are already known [6,15,[61][62][63][64][65][66][67]. Kudera et al [66] reported in vitro growth inhibitory activity of C. inophyllum extract against diarrhea-causing microorganisms, e.g., Clostridium difficile infant, Clostridium perfringens, Enterococcus faecalis, Escherichia coli, Listeria monocytogenes and Salmonella enterica. The extract was particularly active against C. perfringens and L. monocytogenes (MIC = 128 µg/mL).…”

Section: Antimycobacterial Activitymentioning

confidence: 99%

Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential

Nahar

Talukdar

Nath³

et al. 2020

Molecules

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Calanolides are tetracyclic 4-substituted dipyranocoumarins. Calanolide A, isolated from the leaves and twigs of Calophyllum lanigerum var. austrocoriaceum (Whitmore) P. F. Stevens, is the first member of this group of compounds with anti-HIV-1 activity mediated by reverse transcriptase inhibition. Calanolides are classified pharmacologically as non-nucleoside reverse transcriptase inhibitors (NNRTI). There are at least 15 naturally occurring calanolides distributed mainly within the genus Calophyllum, but some of them are also present in the genus Clausena. Besides significant anti-HIV properties, which have been exploited towards potential development of new NNRTIs for anti-HIV therapy, calanolides have also been found to possess anticancer, antimicrobial and antiparasitic potential. This review article provides a comprehensive update on all aspects of naturally occurring calanolides, including their chemistry, natural occurrence, biosynthesis, pharmacological and toxicological aspects including mechanism of action and structure activity relationships, pharmacokinetics, therapeutic potentials and available patents.

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Section: Antimycobacterial Activitymentioning

confidence: 99%

Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential

Nahar

Talukdar

Nath³

et al. 2020

Molecules

View full text Add to dashboard Cite

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Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species: Inhibition of Nucleic Acid Synthesis

Heilman,

Hui,

Mian

et al. 2023

ChemistrySelect

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Plants are valuable resources for the development of novel pharmaceutical products. The increasing threat to global health caused by antibiotic resistance remains a serious concern, driven a need to discover and evaluate novel anti‐bacterial agents. Calophyllum species are known for having excellent biological activity due to its secondary metabolites, such as xanthone. Numerous xanthones have been found to possess anti‐bacterial properties that are effective against plant pathogens, hence can be applied to fight human pathogens. Topoisomerase enzymes (DNA gyrase and topoisomerase IV) are DNA metabolism enzymes that possess distinct roles as unlinking enzymes during DNA replication. Nucleic acid synthesis inhibition reduces bacteria proliferation through the inhibition of topoisomerase enzymes that are essential for bacterial growth. The xanthone isolated from Calophyllum and its anti‐bacterial were discussed in this review. Besides, molecular docking simulations were applied to explore the potential binding mode of xanthones to DNA metabolism enzymes. The docking study displayed that biscaloxanthone is a good topoisomerase enzymes inhibitor compared to their co‐cystalize ligand, novobiocin and BDBM50198240. The complied information and molecular docking simulations suggested that xanthone isolated possesses potential anti‐bacterial agents inhibiting nucleic acid synthesis. Besides, it suggested that the anti‐microbial activity of xanthone contributes from the topoisomerase enzyme‘s inhibition.

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<i>In vitro</i> growth-inhibitory activity of <i>Calophyllum inophyllum</i> ethanol leaf extract against diarrhoea-causing bacteria

Cited by 2 publications

References 17 publications

Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential

Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential

Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species: Inhibition of Nucleic Acid Synthesis

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