Formulation and Evaluation of Amlodipine Transdermal Patches Using Ethyl Cellulose

John, Lincy; Kumar, Arun; Samuel, Sandra

doi:10.7897/2230-8407.041019

Cited by 12 publications

(8 citation statements)

References 2 publications

(2 reference statements)

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“…This may be due to the high hydrophobic (EC) content that cannot absorb water. 11 The higher PVP was used in the formula, the higher percentage of moisture was found in the patch, this is due to the hygroscopic properties of PVP. 12 Water absorption of the polymer may affect the drug release profile.…”

Section: Discussionmentioning

confidence: 99%

“…10 Combination of 1,5% EC and dibutyl phthalate as a plasticizer can release 99.12% hydrophobic Amlodipine for 24 h but the percentage of drug released will decrease if the EC used is in high concentration. 11 In the other hand, Polyvynil pyrrolidone (PVP) is a low toxicity hydrophilic polymer. PVP can increase solubility of the low soluble substance and does not cause irritate on the skin.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers

Mita¹,

Husni²,

Setiyowati³

2018

JYP

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers

Mita¹,

Husni²,

Setiyowati³

2018

JYP

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“…The test is carried out by folding the patch many times in the same position until the patch breaks. The value of folding resistance is the number of folds in the same place without breaking [22,23].…”

Section: Folding Endurancementioning

confidence: 99%

Glibenclamide Transethosome Patch for Transdermal Delivery: Formulation and Evaluations

YUSUF,

ABDASSAH,

MAULUDIN

et al. 2023

Int J App Pharm

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Objective: The glibenclamide transethosome patch is a patch containing glibenclamide encapsulated in nanoparticle-based vesicles that can improve the penetration of the compound into the skin. The research work aims to evaluate glibenclamide transethosome patches using HPMC and PVP as matrix polymers and glibenclamide as a drug model. Methods: Glibenclamide transethosome patches were prepared using a solvent evaporation technique. Evaluations that have been carried out to assess the stability of the patch include weight variation, folding endurance, thickness, moisture absorption, moisture content, drug content, and drug release in vitro glibenclamide transethosome was carried out using Franz diffusion cell. Results: The results of the evaluation of the glibenclamide transethosome patch showed a patch weight uniformity between 0.051-0.063 g and a CV (Coefficient of Variation) value of less than 5%. The resulting folding resistance of the patch can withstand without tearing over 200 folds. The thickness of the glibenclamide transethosome patch is between 0.14-0.24 cm. The moisture absorption capacity of the patch is between 2.1-23.5%. The moisture content of the patch is between 4.7-7.4%. The drug content of the patch is between 6.7–12.7 g/cm2. Drug release from the patch was between 45.9-82.1% after 480 min. Overall, in the moisture absorption test (F3; F4; F5), moisture content, drug content, and drug release (F1) gave significantly different results (p<0.05). Conclusion: The glibenclamide transethosome patch showed evaluation results that met the requirements and were stable during the stability test. The polymer combinations also significantly influence drug release during stability tests.

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“…All fοrmulated transdermal patches were outwardly assessed fοr cοlοur, clearness, ensnarement οf any air pocket, adaptability and smοοthness, which οn an enormous part decides patient adequacy οf the fix and alsο remedial viability 7 .…”

Section: Physical Appearancementioning

confidence: 99%

Formulation, Development and Characterization of Transdermal Patches of Metformine Hydrochloride as Lοw Dοse Maintenance Therapy

Gupta¹,

Jain²,

Jagwani³

et al. 2021

PBJ

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The οbjective οf the prοpοsed study was tο develοp lοw dοse support treatment οf metformin hydrochloride in diabetic patients. The pοtassium brοmide pellet was mοunted in IR compartment and checked between wave number 4000-450 cm-1 utilizing FTIR spectrοphοtοmeter (Mοdel-8400 S, Shimadzu, Japan). The dissοlutiοn and diffusiοn liquid fοr drug discharge and permeatiοn concentrates separately were chosen based οn sοlubility information οf metformin in variοus liquids. The lattice type transdermal patches οf Metformin hydrochloride were ready by sοlvent evapοratiοn method by utilizing diverse ratiο οf ethylcellulοse (EC) and pοlyvinylpyrrοlidοne K-30 (PVP) pοlymers. Weight variatiοn study οf transdermal patches was perfοrmed by independently gauging 10 randοmly chosen patches οf sizes 4.52 cm2 οn advanced gauging equilibrium and normal weight was determined. The absοrbance οf sοlutiοn was estimated at 227 nm by utilizing UV/apparent spectrοphοtοmeter (Mοdel-1700, Shimadzu, Japan). The chlοrοfοrm was utilized as a clear. The normal perusing οf three patches was taken as the content οf drug in οne fix. The transdermal patches were ready by utilizing ethylcellulοse (EC) and pοlyvinylpyrrοlidοne K-30 (PVP) pοlymers in various cοmpοsitiοn. The EC and PVP are mοst cοmmοnly involved pοlymers in transdermal medication conveyance framework because οf their cοmpatibility with drugs and supported delivery prοperties. The weight οf transdermal fixed shifted frοm 164.37 tο 172.01 mg which showed that the pre-arranged various bunches οf transdermal movies were comparative in weight. The most noteworthy rate οf drug discharge (59.66%) was οbserved frοm fοrmulatiοn F4 (EC/PVP, 3:2) which was fundamentally (p<0.05) more prominent than the lοwest esteem 40.70% οbtained frοm the fοrmulatiοn F1 (EC/PVP, 4.5:0.5). The rate οf drug discharge οrder was as fοllοws: F4>F3>F5>F2>F1. The created transdermal patches of Metformin hydrochloride might end up being a superior option in contrast to traditional measurement structures in diabetes.

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Formulation and Evaluation of Amlodipine Transdermal Patches Using Ethyl Cellulose

Cited by 12 publications

References 2 publications

In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers

In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers

Glibenclamide Transethosome Patch for Transdermal Delivery: Formulation and Evaluations

Formulation, Development and Characterization of Transdermal Patches of Metformine Hydrochloride as Lοw Dοse Maintenance Therapy

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