2013
DOI: 10.7897/2230-8407.041019
|View full text |Cite
|
Sign up to set email alerts
|

Formulation and Evaluation of Amlodipine Transdermal Patches Using Ethyl Cellulose

Abstract: The aim of our study was to design and evaluate Amlodipine transdermal patches using polymers such as ethyl cellulose. Matrix type transdermal patches containing Amlodipine were prepared by solvent casting method by using polymers like ethylcellulose 1 %, 1.5 %, 2 % and 2.5 % and a total of eight formulations were prepared. Plasticizers used were propylene glycol and dibutylpthalate. The transdermal patches were evaluated for their physicochemical properties like folding endurance, thickness, percentage moistu… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
4
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 12 publications
(8 citation statements)
references
References 2 publications
(2 reference statements)
0
4
0
Order By: Relevance
“…This may be due to the high hydrophobic (EC) content that cannot absorb water. 11 The higher PVP was used in the formula, the higher percentage of moisture was found in the patch, this is due to the hygroscopic properties of PVP. 12 Water absorption of the polymer may affect the drug release profile.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This may be due to the high hydrophobic (EC) content that cannot absorb water. 11 The higher PVP was used in the formula, the higher percentage of moisture was found in the patch, this is due to the hygroscopic properties of PVP. 12 Water absorption of the polymer may affect the drug release profile.…”
Section: Discussionmentioning
confidence: 99%
“…10 Combination of 1,5% EC and dibutyl phthalate as a plasticizer can release 99.12% hydrophobic Amlodipine for 24 h but the percentage of drug released will decrease if the EC used is in high concentration. 11 In the other hand, Polyvynil pyrrolidone (PVP) is a low toxicity hydrophilic polymer. PVP can increase solubility of the low soluble substance and does not cause irritate on the skin.…”
Section: Introductionmentioning
confidence: 99%
“…The test is carried out by folding the patch many times in the same position until the patch breaks. The value of folding resistance is the number of folds in the same place without breaking [22,23].…”
Section: Folding Endurancementioning
confidence: 99%
“…All fοrmulated transdermal patches were outwardly assessed fοr cοlοur, clearness, ensnarement οf any air pocket, adaptability and smοοthness, which οn an enormous part decides patient adequacy οf the fix and alsο remedial viability 7 .…”
Section: Physical Appearancementioning
confidence: 99%