Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method

Abstract

Nanostructured lipid carrier (NLC) was prepared by homogenization emulsification method and improved with modified surfactants. The properties of nanoparticles were investigated using the NLC system for hydroquinone (HQ) as a model drug and by increasing the light stability of hydroquinone. The optimized condition of NLC in stirring was 1200 rpm, the homogenized speed was 8000 rpm, solid oil to liquid oil ratio was 3 : 7, and lecithin to surfactant ratio was 3 : 1. The particle size was 393.30 ± 28.23 nm and the encapsulation efficiency was 22.13 ± 2.66%. The zeta-potential of HQ-NLC was better than −30 mV. In the thermogravimetric analysis (TGA) studies, adding of PLANTACARE 2000 UP for HQ-NLC has better heat resisting property than the HQ-NLC only. The addition of PLANTACARE 2000 UP to NLC shows better permeability (125.10%) than that of Blank. In the stability studies, the HQ-NLC after UVA/UVB irradiation has better inhibition rate (34.25%) than that of the Blank. In the present study, NLC system has successfully improved the light stability and the skin permeability of active compound. Therefore, the NLC might be a potential delivery vehicle for transdermal products in the future.

Application of Response Surface Methodology for the Optimization of β‐Carotene‐Loaded Nanostructured Lipid Carrier from Mixtures of Palm Stearin and Palm Olein

“…The thermal analysis was used to characterize the mobility and interaction between polymers during the heating process at a controlled level (Wu et al, ). Differential scanning calorimetry (DSC) was used to investigate thermal activity, and TGA was used to monitor the weight reduction when heated.…”

Management of hyperpigmentation: Current treatments and emerging therapies

“…Skin irritation tests showed no erythema or irritation with the CUR-SLN gel, marking it safe for topical use (Shrotriya et al, 2018). Wu et al, 2017 formulated hydroquinone-NLC wherein the rate of tyrosinase inhibition by hydroquinone-NLC was found to be 42.39%% ± 0.63% as compared to 28.40%% ± 1.12% of hydroquinone solution, suggesting improved light stability of hydroquinone by NLC and thus showed better tyrosinase inhibition assay (Wu et al, 2017).…”

Features, applications, and sustainability of lipid nanoparticles in cosmeceuticals

“…They used the homogenization emulsification technique to prepare the nanoparticles obtaining a particle size of 393.30 ± 23 nm and loading efficiency of 22.13 ± 2.66%. These nanoparticles showed better skin permeability (125.1%) and better light stability after UVA/UVB irradiation with an inhibition rate (34.25%) in comparison to the blank ( Wu et al, 2017 ).…”

“…In vitro penetration analysis demonstrated three times higher drug accumulation in the skin and much less hydroquinone entrance to the systematic circulation ( Ghanbarzadeh et al, 2015 ). In another study done by Wu et al, they prepared a nanostructured lipid carrier (NLC) loaded with hydroquinone to improve its light stability ( Wu et al, 2017 ). They used the homogenization emulsification technique to prepare the nanoparticles obtaining a particle size of 393.30 ± 23 nm and loading efficiency of 22.13 ± 2.66%.…”