Formulasi Dan Evaluasi Transdermal Patch Kalium Diklofenak

Abstract

<p align="center"><strong>Abstrak</strong></p><p><em> </em></p><p>Kalium diklofenak adalah salah satu obat golongan anti-inflamasi non steroid (AINS) yang memberikan efek samping iritasi pada saluran pencernaan. Tujuan penelitian ini adalah melakukan formulasi dan evaluasi sediaan dengan rute alternatif lain penggunaan kalium diklofenak melalui transdermal <em>patch. Patch </em>dibuat dengan metode penguapan pelarut. Polivinil pirolidon (PVP) digunakan sebagai polimer untuk pembentukan <em>patch </em>transdermal kalium diklofenak dengan dibutil ftalat (DBP) sebagai <em>plasticizer </em>dan mentol sebagai peningkat penetrasi. Uji <em>in vitro</em> dilakukan dengan alat difusi modifikasi <em>Franz </em>dan ditentukan dengan spektroskopi UV-sinar tampak. Kadar zat aktif, berat, ketebalan dan organoleptis dari <em>patch </em>juga ditentukan. Hasil penelitian menunjukan bahwa rata-rata uji laju difusi sediaan <em>patch </em>1,3884 mg/cm<sup>2</sup> dengan persen permeasi sebesar 8,9 % selama 180 menit.</p><p> </p><p><strong>Kata Kunci :</strong><strong> </strong>Transdermal; <em>Patch</em>; kalium diklofenak; mentol.<strong></strong></p><p><em> </em></p><p align="center"><strong><em>Formulation and Evaluation Patch Transdermal Diclofenac Potassium</em></strong></p><p align="center"><em> </em></p><p align="center"><strong><em>Abstract</em></strong></p><p><em> </em></p><p><em>Diclofenac potassium is one of the non-steroidal anti-inflammatory drugs (NSAIDs) that provides irritating side effects to the digestive tract. The purpose of this study is to formulate and evaluate preparations with alternative routes of using potassium diclofenac through the transdermal patch. </em><em>Preparation of </em><em>the matrix patches used the solvent casting method. Polyvinyl pyrrolidone (PVP) was used as a matrix for the formation of transdermal diclofenac potassium patches, dibutyl phthalate (DBP) as the plasticizer and menthol as the permeation enhancer. The in vitro assay was carried out in a modified Franz diffusion cell and the rates of diffusion were determined by UV spectroscopy. The average drug content, thickness, organoleptic, weight uniformity of the matrix patches was also determined. The results showed that the average dosage rate of diffusion test Patch </em><em>is </em><em>1,3884 mg/cm<sup>2</sup> with permeation percentage 8,9 % for 180 minutes. </em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: </em><em>Transdermal; Patch; diclofenac potassium; menthol</em></p>

Optimization of Diclofenac Potassium Transdermal Patch Formula Using a Combination of Polyvynil Pyrrolidone K 30, Ethyl Cellulose and Menthol With Simplex Lattice Design Method

“…To determine the drug content in each formulation, the maximum wavelength is 276 nm. The obtained absorbance is compared with the calibration curve to determine the concentration of potassium diclofenac in the patch preparation (Purnamasari et al, 2019).…”

“…Formulas with non-smooth and cracked film conditions were found more in F5 and F7, which had a higher concentration of ethyl cellulose polymer. Purnamasari et al, (2019) stated in their research that a polymer combination of PVP:ethyl cellulose (1:3) produces a white, clear, and non-smooth patch. The results of the organoleptic test for diclofenac potassium film patches can be seen in the Table 3.…”

“…The transdermal delivery system has many advantages, including easy use, reducing the frequency of drug administration, eliminating first-pass metabolism, ensuring more uniform plasma levels, and reducing side effects such as gastric irritation and patient compliance (Puspitasari et al, 2016). Purnamasari et al, 2019 have formulated and evaluated potassium diclofenac transdermal patches, and the results of the study showed that patches with PVP polymer were good both physically and homogeneously, as well as in in-vitro penetration tests. However, to determine the composition of the patch preparation that produces optimum physical characteristics, optimization is needed, including the simplex lattice design (SLD) method (Suryani et al, 2015).…”

The Effect of Polymers Ratio Carboxymethyl Chitosan, Polyvinyl Pyrolidone K-30, and Ethyl Cellulose N22 on Physico-Chemical Characteristics and Drug Release from Matrix Type Diclofenac Potassium Patch

“…Oral use of diclofenac potassium can cause gastrointestinal side effects such as bleeding and peptic ulceration due to COX inhibition, which reduces prostaglandins in the gastric epithelium (Purnamasari et al, 2019). Diclofenac potassium has a short half-life of 1-3 hours and undergoes extensive first-pass metabolism in the liver that is only 50% of the systemically available oral dose (Rajabalaya et al, 2008).…”