The Effect of Polymers Ratio Carboxymethyl Chitosan, Polyvinyl Pyrolidone K-30, and Ethyl Cellulose N22 on Physico-Chemical Characteristics and Drug Release from Matrix Type Diclofenac Potassium Patch
Abstract:Background: Diclofenac potassium is an NSAID drug that is used in the treatment of mild to moderate pain. The use of this drug orally can cause side effects in the gastrointestinal tract, and the drug will undergo extensive first-pass metabolism in the liver. Therefore, preparations for transdermal patches were made. Objective: Determining the effect of the polymer ratios of carboxymethyl chitosan, polyvinyl pyrolidone K-30, and ethyl cellulose N22 on the physicochemical characteristics and drug release of a m… Show more
“…It is thought that the drugs release can happen concurrently in every area of the patch if the drug is evenly distributed. 20 The drug homogeneity percentage results displayed in Table 2, demonstrated variations in levels across all formula indicated by %CV values exceeding 6%. This suggests an uneven distribution of diclofenac sodium on the patch.…”
Section: Drug Homogeneity Test Of Patchmentioning
confidence: 96%
“…The absorbance of the samples was observed using a UV Spectrophotometer at a wavelength of 276.6 nm. 20…”
Section: Release and In Vitro Penetration Evaluationmentioning
Material and Methods
MaterialsDiclofenac sodium (Manufactured by PT. Dexa Medica, Indonesia); other materials used were stearic acid (Avantor Performance Materials Taiwan Co.,Ltd, Hsinchu), oleic acid (Marks & Nos Inc), Tween 80
“…It is thought that the drugs release can happen concurrently in every area of the patch if the drug is evenly distributed. 20 The drug homogeneity percentage results displayed in Table 2, demonstrated variations in levels across all formula indicated by %CV values exceeding 6%. This suggests an uneven distribution of diclofenac sodium on the patch.…”
Section: Drug Homogeneity Test Of Patchmentioning
confidence: 96%
“…The absorbance of the samples was observed using a UV Spectrophotometer at a wavelength of 276.6 nm. 20…”
Section: Release and In Vitro Penetration Evaluationmentioning
Material and Methods
MaterialsDiclofenac sodium (Manufactured by PT. Dexa Medica, Indonesia); other materials used were stearic acid (Avantor Performance Materials Taiwan Co.,Ltd, Hsinchu), oleic acid (Marks & Nos Inc), Tween 80
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.