Formula Jamu Antihipertensi and captopril are equally effective in patients with hypertension

Abstract

BACKGROUND<br />Hypertension is the main cause of morbidity and mortality associated with cardiovascular diseases. Many herbs/spices appear to have significant effects in favorably modulating high blood pressure. A jamu formulation containing 6 plant extracts, Formula Jamu Antihipertensi (FJA), has been described previously. This research study aimed to evaluate the effect of FJA as antihypertensive agent in mild to moderate hypertensive patients. <br /><br />METHODS<br />This double-blind experimental study was conducted in 40 hypertensive patients, who were randomized into two groups. The first group was treated with oral administration of 2 g FJA and the second group 25 mg captopril daily for 4 weeks. Systolic and diastolic blood pressure as well as liver and kidney function were followed up every week. Independent- t test and two-way ANOVA were used to analyze the data with a level of significance of 0.05.<br /><br />RESULTS<br />The results showed that after the treatment, FJA and captopril were capable of significantly decreasing systolic and diastolic blood pressure (p <0.05). The decrease in systolic blood pressure between the two groups was identical (p>0.05), while the decrease in diastolic blood pressure was greater in the FJA group than in the captopril group (p <0.05). <br /><br />CONCLUSION<br />From this study it may be concluded that administration of FJA for 4 weeks is equally effective as captopril in reducing systolic and diastolic blood pressure in patients with mild and moderate hypertension. Thus, natural plants and herbs can be our source of drugs, with fewer side effects and better bioavailability for treatment of hypertension in the future.

Pola Penggunaan Obat Bahan Alam Sebagai Terapi Komplementer pada Pasien Hipertensi Di Puskesmas

“…Sementara itu, Riskesdas tahun 2010 menunjukkan 60% penduduk Indonesia diatas usia 15 tahun menyatakan pernah minum jamu, dan 90% diantaranya menyatakan adanya manfaat minum jamu (Aditama, 2014 (Hussaana et al, 2016). Berdasarkan hal tersebut diatas, maka penelitian ini bermaksud untuk mengetahui pola penggunaan obat bahan alam sebagai terapi komplementer pada pasien hipertensi di puskesmas.…”

“…Hal ini sesuai dengan FJA (Formula Jamu Antihipertensi) yang disusun oleh Komisi Nasional Saintifikasi Jamu, mengandung komposisi diantaranya herba seledri. Tumbuhan ini mengandung flavonoid (apiin dan apigenin) serta kumarin (Hussaana et al, 2016). Efek antihipertensi seledri melalui mekanisme penghambatan kanal ion kalsium (Tashakori-Sabzevara et al, 2016), dan penghambatan pada ACE (Simaratanamongkol et al, 2014).…”

Standardization of Indonesian Traditional Antihypertensive Medicines (Jamu) through the ACE Inhibitor Mechanism

“…This matter caused by several factors, especially the prices of traditional medicines considered cheaper with less side effect. 4 The goal of treatment of hypertension with medicinal plants is to treat high blood pressure by correcting the cause according to the philosophy of medicinal plants as constructive medicine, namely repairing/building damaged organs or systems that cause hypertension. Medicinal plants have advantages in the treatment of hypertension because generally, medicinal plants have a function other than managing hypertension as well as treating comorbidities or complications as a result of high blood pressure.…”

Comparison of Adherence to the Use of Herbal Medicine with Conventional Medicine in Hypertensive Patients at Lempake Public Health Center, Samarinda City

“…The results of this study are slightly different from the national standard antihypertensive herbal formulation consisting of medicinal plant extracts, including celery (Apium graveolens) herbs and whiskers cat (Orthosiphon aristatus) leaves. These herbal medicines have been officially recommended for hypertension by the Ministry of Health, Republic of Indonesia 5 .…”

“…The use of herbal medicine for hypertension has increased in the past decade. The price of herbal medicines is considered cheaper with fewer side effects 5 . Research about herbal medicine usage for hypertension as the most frequent chronic diseases in Indonesia is still limited.…”