Fluorouracil paste treatment of thin basal cell carcinomas

5% fluorouracil chemowraps in the management of widespread lower leg solar keratoses and squamous cell carcinoma

“…Occluded wounds heal faster and patients report less pain than non‐occluded wounds . Occlusion is also well known to cause an increase in the potency of topical preparations including Efudix and may help to explain the improved response to topical treatment alone …”

5% fluorouracil chemowraps in the management of widespread lower leg solar keratoses and squamous cell carcinoma

“…Occluded wounds heal faster and patients report less pain than non‐occluded wounds . Occlusion is also well known to cause an increase in the potency of topical preparations including Efudix and may help to explain the improved response to topical treatment alone …”

A Pilot Study to Evaluate the Treatment of Basal Cell Carcinoma with 5-Fluorouracil Using Phosphatidyl Choline as a Transepidermal Carrier

“…Superficial multicentric BCCs have been treated effectively with topical 5-FU, 3-6 but the 5-year recurrence rate is unacceptably high at 21%. 7 Deeper lesions are completely unresponsive to this treatment modality, likely due to insufficient penetration of the drug through the epidermis. Due to this limitation, intralesional chemotherapeutics and topical transepidermal carriers have been used to improve the penetration of topical chemotherapeutics.…”

Current modalities and new advances in the treatment of basal cell carcinoma

“…Although rigorous data are lacking, reports of 5-FU in combination with curettage or cryotherapy have suggested that combination therapy may be more effective than monotherapy. 51,52 In the same study, 51 light curettage of 244 sBCC tumors before the 25% fluorouracil regimen resulted in a 5-year cumulative recurrence rate of 6%, compared with the above-noted 21% for the fluorouracil regimen alone. Because limited data are available, the actual clearance rate for the topical treatment of sBCC with 5-FU is currently unknown.…”

“…In a small study, 44 sBCC tumors were treated with a high concentration of medication, administered as a 25% fluorouracil paste, with occlusion that was changed once weekly for 3 weeks. 51 This treatment regimen resulted in a 5-year recurrence rate of 21%. Although rigorous data are lacking, reports of 5-FU in combination with curettage or cryotherapy have suggested that combination therapy may be more effective than monotherapy.…”

5% fluorouracil chemowraps in the management of widespread lower leg solar keratoses and squamous cell carcinoma

“…Occluded wounds heal faster and patients report less pain than non‐occluded wounds . Occlusion is also well known to cause an increase in the potency of topical preparations including Efudix and may help to explain the improved response to topical treatment alone …”

A Pilot Study to Evaluate the Treatment of Basal Cell Carcinoma with 5-Fluorouracil Using Phosphatidyl Choline as a Transepidermal Carrier

“…Superficial multicentric BCCs have been treated effectively with topical 5-FU, 3-6 but the 5-year recurrence rate is unacceptably high at 21%. 7 Deeper lesions are completely unresponsive to this treatment modality, likely due to insufficient penetration of the drug through the epidermis. Due to this limitation, intralesional chemotherapeutics and topical transepidermal carriers have been used to improve the penetration of topical chemotherapeutics.…”

Current modalities and new advances in the treatment of basal cell carcinoma

“…Although rigorous data are lacking, reports of 5-FU in combination with curettage or cryotherapy have suggested that combination therapy may be more effective than monotherapy. 51,52 In the same study, 51 light curettage of 244 sBCC tumors before the 25% fluorouracil regimen resulted in a 5-year cumulative recurrence rate of 6%, compared with the above-noted 21% for the fluorouracil regimen alone. Because limited data are available, the actual clearance rate for the topical treatment of sBCC with 5-FU is currently unknown.…”

“…In a small study, 44 sBCC tumors were treated with a high concentration of medication, administered as a 25% fluorouracil paste, with occlusion that was changed once weekly for 3 weeks. 51 This treatment regimen resulted in a 5-year recurrence rate of 21%. Although rigorous data are lacking, reports of 5-FU in combination with curettage or cryotherapy have suggested that combination therapy may be more effective than monotherapy.…”

5% fluorouracil chemowraps in the management of widespread lower leg solar keratoses and squamous cell carcinoma

“…Occluded wounds heal faster and patients report less pain than non‐occluded wounds . Occlusion is also well known to cause an increase in the potency of topical preparations including Efudix and may help to explain the improved response to topical treatment alone …”

A Pilot Study to Evaluate the Treatment of Basal Cell Carcinoma with 5-Fluorouracil Using Phosphatidyl Choline as a Transepidermal Carrier

“…Superficial multicentric BCCs have been treated effectively with topical 5-FU, 3-6 but the 5-year recurrence rate is unacceptably high at 21%. 7 Deeper lesions are completely unresponsive to this treatment modality, likely due to insufficient penetration of the drug through the epidermis. Due to this limitation, intralesional chemotherapeutics and topical transepidermal carriers have been used to improve the penetration of topical chemotherapeutics.…”

Current modalities and new advances in the treatment of basal cell carcinoma

“…Although rigorous data are lacking, reports of 5-FU in combination with curettage or cryotherapy have suggested that combination therapy may be more effective than monotherapy. 51,52 In the same study, 51 light curettage of 244 sBCC tumors before the 25% fluorouracil regimen resulted in a 5-year cumulative recurrence rate of 6%, compared with the above-noted 21% for the fluorouracil regimen alone. Because limited data are available, the actual clearance rate for the topical treatment of sBCC with 5-FU is currently unknown.…”

“…In a small study, 44 sBCC tumors were treated with a high concentration of medication, administered as a 25% fluorouracil paste, with occlusion that was changed once weekly for 3 weeks. 51 This treatment regimen resulted in a 5-year recurrence rate of 21%. Although rigorous data are lacking, reports of 5-FU in combination with curettage or cryotherapy have suggested that combination therapy may be more effective than monotherapy.…”