Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

Fernandes, Ana Rita; Santos, Ana Cristina; Kovačević, Andjekla B; Espina, Marta; Calpena, Ana Cristina; Veiga, Francisco; García, María Laura; Souto, Eliana B.

doi:10.1159/000479529

Cited by 12 publications

(36 citation statements)

References 103 publications

(157 reference statements)

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“…Basal cell carcinoma (BCC) is known as the most common cancer of skin with a good prognosis, mainly caused by photogenic mutations in patched homolog 1 (PTCH1) gene (Bukhardt Pérez, Ruiz‐Villaverde, Naranjo Díaz, Blasco Melguizo, & Naranjo, ; Fernandes et al, ; Helsing, Gjersvik, & Tarstedt, ; Lear, Harvey, Berker, Strange, & Fryer, ). BCC is followed by clinical manifestations in middle adulthood such as telangiectasia, pigmented areas, rodent ulcer and red patch (Elghissassi et al, ; Marzuka & Book, ).…”

Section: Introductionmentioning

confidence: 99%

Association of programmed death‐1 gene polymorphisms with the risk of basal cell carcinoma

Fathi

Ebrahimi

Eslami

et al. 2019

Int J Immunogenetics

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Environmental and genetic factors play a fundamental role in the pathogenesis of basal cell carcinoma (BCC) defined as the most common cancer of skin. Programmed death‐1 (PD‐1), encoded by programmed cell death‐1 (PDCD1) gene, serves as an inhibitory molecule in the suppression of immune responses and a risk factor in the development of different cancers. In this study, we investigated the role of two single nucleotide polymorphisms (SNPs) within PDCD1 gene, and haplotypes defined by these SNPs, in the development of BCC in an Iranian population. Whole blood samples were obtained from 210 BCC and 320 healthy subjects. Genomic DNA was extracted from whole blood samples, polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) was used to genotype determinations of PD1.3 (rs11568821) and PD1.5 (rs2227981) SNPs, and 4 haplotypes were constructed by PDCD1 SNPs. The frequency of G allele of PD1.3 was significantly higher in BCC patients than healthy subjects (p < 0.02), while these significant differences were not observed in the frequencies of PD1.5 alleles between BCC and healthy subjects. Moreover, we found that there were no statistically significant differences in PD1.3 and PD1.5 genotypes between BCC and control groups. Of all estimated haplotypes for PDCD1, only AC haplotype was associated with BCC (OR = 0.22, 95% CI = 0.06–0.79, p < 0.01). These findings suggest that PD1.3G allele and AC haplotype of PDCD1 contribute to BCC in the Iranian population. However, further studies in different populations with larger sample size are required to confirm this study.

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Section: Introductionmentioning

confidence: 99%

Association of programmed death‐1 gene polymorphisms with the risk of basal cell carcinoma

Fathi

Ebrahimi

Eslami

et al. 2019

Int J Immunogenetics

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“…Although chemotherapeutic drugs in general are effective in destroying neoplastic cells, the major challenge is the distinction between neoplastic and normal cells. This lack of specificity of chemotherapeutic drugs is a serious limiting factor, due to several adverse effects such as diarrhea, vomiting, nausea, alopecia and greater risk of serious infections [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic, Antitumor and Toxicological Profile of Passiflora alata Leaf Extract

et al. 2020

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Passiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread from Peru to Brazil. The plant has long been used in folks medicine for its pharmacological properties and is included in the Brazilian Pharmacopoeia since 1929. The aim of this study was to evaluate the potential cytotoxic and antitumor activities of Passiflora alata leaf extract (PaLE) in S180-tumor bearing mice. The percentage of cell proliferation inhibition (% CPI) and IC50 in relation to 4 tumor cell lines were determined in PC3, K-562, HepG2 and S180 cell lines using the MTT assay. PaLE showed a CPI > 75% and greater potency (IC50 < 30 µg/mL) against PC3 and S180 cell lines. PaLE showed antitumor activity in treatments intraperitoneally (36.75% and 44.99% at doses of 100 and 150 mg/kg/day, respectively). Toxicological changes were shown in the reduced body mass associated with reduced food consumption, increased spleen mass associated with histopathological increase in the white pulp of the spleen and increased number of total leukocytes with changes in the percentage relationship between lymphocytes and neutrophils. Our outcomes corroborate the conclusion that PaLE has antitumor activity in vitro and in vivo with low toxicity.

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“…As claudinas podem ser divididas em dois grupos em termos de homologia de sequência (linha tracejada): as claudinas humanas "clássicas" são indicadas em vermelho e as "não clássicas" em preto. Fonte: Adaptado de Lal-Nag M, Morin PJ (2009) 103 Uma outra classificação, baseada na seletividade iônica das claudinas, divide as isoformas pela funcionalidade nas categorias de "coesão", como as claudinas -4, -5, -8, -11, -14 e -19, e na de capacidade de "formação de poros", como as claudinas -2, -7, -10 e -15 107 [134][135][136] . Trata-se de um tumor primário da pele, originário da proliferação maligna de queratinócitos da epiderme 135 .…”

Section: Classificação Das Claudinasunclassified

“…Fonte: Adaptado de Lal-Nag M, Morin PJ (2009) 103 Uma outra classificação, baseada na seletividade iônica das claudinas, divide as isoformas pela funcionalidade nas categorias de "coesão", como as claudinas -4, -5, -8, -11, -14 e -19, e na de capacidade de "formação de poros", como as claudinas -2, -7, -10 e -15 107 [134][135][136] . Trata-se de um tumor primário da pele, originário da proliferação maligna de queratinócitos da epiderme 135 . Geralmente ocorre nas áreas com fotoexposição crônica, como cabeça, pescoço e extremidades 134 .…”

Section: Classificação Das Claudinasunclassified

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Perfil de expressão de claudinas nas lesões de verruga plana e carcinomas cutâneos na epidermodisplasia verruciforme

Silva¹

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Síndrome da imunodeficiência adquirida ALA ácido 5-aminolevulínico BAK "BCL2-antagonist/killer" BSA soro albunima bovina BSA CAPPEsq Comissão de ética para análise de projetos de pesquisa CCL20 "chemokine (C-C motif) ligand 20" CDX "caudal-type homeobox" CEC carcinoma espinocelular CIB1 gene ou proteína-1 de ligação cálcio e integrina CPE enterotoxina do Clostridium perfringens DA dermatite atópica DAPI "4′,6-diamidino-2-phenylindole" DNA ácido desoxirribonucleico DNp73 delta Np73 E2F fator E2 E6-AP proteína associada a E6 EGF fator de crescimento epidérmico EMT transição epitelial-mesenquimal EUA Estados Unidos da América EV epidermodisplasia verruciforme EVER1 EVER2 genes "Epidermodysplasia Verruciformis Enhancing Region" GATA fator de transcrição de ação "trans" específico de células T HE hematoxilina-eosina HGF fator de crescimento dos hepatócitos _____________________________________________________________________________

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Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

Cited by 12 publications

References 103 publications

Association of programmed death‐1 gene polymorphisms with the risk of basal cell carcinoma

Association of programmed death‐1 gene polymorphisms with the risk of basal cell carcinoma

Cytotoxic, Antitumor and Toxicological Profile of Passiflora alata Leaf Extract

Perfil de expressão de claudinas nas lesões de verruga plana e carcinomas cutâneos na epidermodisplasia verruciforme

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