Skin Cancer and the Solid Organ Transplant Recipient

Patel, Manisha J.; Liégeois, Nanette J.

doi:10.1007/s11864-008-0082-0

Cited by 8 publications

(2 citation statements)

References 40 publications

(40 reference statements)

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“…The primary means of addressing the greater risk of skin cancer in POTRs is education and increased surveillance, although there is little pediatric‐specific information . Studies of educational efforts focus on traditional preventative measures, including photoprotection techniques such as sun aversion, body coverage, and sunscreen use .…”

Section: Prevention and Managementmentioning

confidence: 99%

Cutaneous Malignancies in Pediatric Solid Organ Transplant Recipients

Fogel

Miyar

Teng

2016

Pediatric Dermatology

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Pediatric organ transplant recipients (POTRs) are at risk of developing malignancies due to a combination of immunosuppression, impaired DNA damage repair, and infection with oncogenic viruses. The most commonly developed malignancies in this population are skin cancers, which include nonmelanoma skin cancer, melanoma, Kaposi's sarcoma, and anogenital carcinoma. The literature shows that skin cancers account for 13% to 55% of all cancers that occur after transplantation. Given the increasing number and life expectancy of POTRs, prevention and management of skin cancer in these patients is essential, but there is a substantial knowledge gap in our understanding of the differences in skin cancer development, prevention, and management between POTRs and adult organ transplant recipients (AOTRs), for whom more data are available. Substantial differences have been observed in the patterns of malignancy development between POTRs and AOTRs, and data specific to pediatric populations are needed. The objective of this review is to provide updated information on posttransplantation skin cancer development in POTRs, including epidemiologic research on transplant patients and disease development, medication management, surveillance, and education efforts.

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Section: Prevention and Managementmentioning

confidence: 99%

Cutaneous Malignancies in Pediatric Solid Organ Transplant Recipients

Fogel

Miyar

Teng

2016

Pediatric Dermatology

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“…Long-term antibiotic therapy for 6 months to a year or longer (8,12) is needed to treat Nocardia due both to the slow replication rate of the organisms and to its ability to become an intracellular pathogen that can persist as a cryptic form in the host. In addition, in patients with abscesses, surgical drainage may be required in order to ensure adequate penetration of antibiotics and clearance of the bacteria.…”

Section: Case Reportmentioning

confidence: 99%

Nocardia nova as the Causative Agent in Spondylodiscitis and Psoas Abscess

Hamdad¹,

Vidal²,

Douadi³

et al. 2007

J Clin Microbiol

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We describe here the first case of Nocardia nova spondylodiscitis accompanied by a psoas abscess due to spreading from pulmonary nocardiosis. Nocardia was cultured from all affected sites. After 1 year of an appropriate antimicrobial therapy and a surgical drainage of the abscess that was required, the patient's clinical condition had improved. CASE REPORTIn 2001, a 27-year-old female was admitted to the Department of Nephrology-Transplantation Section because of abdominal and back pain, accompanied by a high-grade fever. In 1991, she was diagnosed with end-stage renal disease due to focal segmental glomerular sclerosis. She was treated for 1 year using hemodialysis, and in 1992 she received her first renal cadaveric transplant, but it was rejected 1 year later. In March 2000, she received a second renal transplant. Because of several episodes of acute rejection despite treatment with prednisone, cyclosporine, and mycophenolate mofetil, the hemodialysis was restarted 6 months later, and the graft was removed. After this surgery, she developed Staphylococcus epidermidis septicemia and an Aspergillus fumigatus pulmonary infection. Immunosuppressive therapy was discontinued and, despite antimicrobial therapy directed against these two infections, 1 month later (October 2000) she developed a second pulmonary infection with high fever, nonproductive cough, and dyspnea. A chest X-ray and computed tomography showed multiple nodules without cavitations.Bronchial aspirate, bronchoalveolar lavage fluid, and a lung biopsy analyses were performed. Direct Gram-stained smears of all specimens showed branched gram-positive rods, and a modified acid-fast stain was positive. Cultures of all specimens grew a Nocardia species. Growth on blood agar and chocolate plates occurred within 3 days of inoculation and showed white opaque and dry colonies, which became chalky and orange with prolonged incubation. The presumptive diagnosis as Nocardia nova complex was obtained from a combination of growth characteristics, aerial hypha production, lysozyme resistance, and a drug susceptibility test performed by the disk diffusion method (5, 20).The patient became afebrile 7 days after the start of a 6-week treatment with intravenous antibiotics, including amikacin (500 mg once daily), imipenem (500 mg three times daily), and trimethoprim-sulfamethoxazole (80 mg of trimethoprim and 400 mg of sulfamethoxazole; two vials of 5 ml administered twice daily), followed by 2 months with the latter two antibiotics alone. Her clinical condition improved rapidly. She was discharged from the hospital and was treated by hemodialysis three times a week.In August 2001, she complained of abdominal and back pain and progressive fever. Her temperature was above 39°C with a normal physical examination except that her back was painful, with the pain was exacerbated when she moved. The spine was tender to palpation at the level of L4-L5 without neurological signs.The laboratory evaluation showed an elevated C-reactive protein (CRP) level of 115 mg/liter and leukoc...

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Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas

2010

AJCC Cancer Staging Manual

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Skin Cancer and the Solid Organ Transplant Recipient

Cited by 8 publications

References 40 publications

Cutaneous Malignancies in Pediatric Solid Organ Transplant Recipients

Cutaneous Malignancies in Pediatric Solid Organ Transplant Recipients

Nocardia nova as the Causative Agent in Spondylodiscitis and Psoas Abscess

Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas

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