Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease

Gao, Liqian; Wang, Wei; Wang, Xuan; Yang, Fen; Xie, Liuxing; Shen, Jun; Brimble, Margaret A.; Xiao, Qicai; Yao, Shao Q.

doi:10.1039/d0cs00115e

Cited by 112 publications

(69 citation statements)

References 250 publications

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“…[ 1 ] As a kind of widely used biological staining material, small molecular organic dyes can realize fluorescence imaging and photoacoustic (PA) imaging of both biological entities and processes. [ 2 ] The spectral wavelength range of organic dyes can be adjusted from UV to near‐infrared (NIR) and is easily degraded, which usually exhibit low long‐term biological toxicity. [ 3 ] In addition, organic dyes are not limited to offer fluorescence emission, their photophysical properties can also be tuned to a large extent by radiative transition to nonradiative transition from excited state.…”

Section: Introductionmentioning

confidence: 99%

Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

Lai

et al. 2021

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114

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Phototheranostics provide a safe, effective, and noninvasive way for the diagnosis and treatment of contemporary diseases, and organic dyes play a vital role. For example, chemical modification endowed dyes with powerful reactive oxygen species or heat generation ability, favoring for photodynamic therapy and photoacoustic (PA) imaging guided photothermal therapy (PTT) of serious diseases. Therefore, photophysical properties manipulation of dyes has become the focus in current dye chemistry research. The development of aggregate science has made great effort to solve this problem. In recent years, a large number of studies have focused on molecular aggregation behavior and its effect on photophysical performance. The most famous example is the discovery of aggregation‐induced emission (AIE) phenomenon. Based on AIE theory, more theories for revealing the relationship between molecular aggregation behavior and photophysical properties were proposed and elucidated. The photophysical property changes caused by dye aggregation have become a unique discipline, guiding the development of molecular science and material science. With the help of molecular self‐assembly, controllable aggregation of dyes can be realized, and stable nano‐theranostic reagents can be obtained. Furthermore, constructing dye assemblies with various photophysical properties will greatly reduce the cost of theranostic reagents, thus, expanding biomedical applications of organic dyes. Therefore, this review focuses on the photophysical characteristic changes caused by dye aggregation and their biological applications including, fluorescence/phosphorescence/PA imaging as well as photodynamic and PTT. This review will provide guidance for the design of organic dyes, the development of controllable aggregation methods, and the construction of multifunctional phototheranostic reagents.

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Section: Introductionmentioning

confidence: 99%

Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

Lai

et al. 2021

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114

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“…The characteristic pathological features of PD involve an altered level of α‐synuclein, dopaminergic neuron deficits, oxidative stress, and metal ion dyshomeostasis. [ 10 ] Neurodegenerative diseases are equally important; AD is considered the fatal disease as it accounts for 60–80% of total dementia cases, followed by PD with high incident rates. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

“…Most of these reviews have emphasized the chemical and morphological aspects of the developed nanomaterials. [ 23 ] Many have summarized the advantages of nanomaterials or molecular probes that improve simultaneous diagnosis and therapy [5a,10a] . In this Review, we mainly focus on recent state‐of‐art advanced nanotechnologies applied in the early‐stage diagnosis of CNS disorders.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology‐Based Strategies for Early Diagnosis of Central Nervous System Disorders

Hanif

Muhammad

Niu

et al. 2021

Advanced NanoBiomed Research

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Central nervous system (CNS) disorders feature the progressive and selective loss of normal brain functions. CNS disorders often include an irreversible physiological and anatomical loss of neurons that can lead to dysfunction in various parts of the brain and eventually death. Glioblastoma multiforme (GBM) and neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) are hard to be diagnosed at an early stage for the prevention of disease propagation. Such diagnosis is vital for the timely commencement of actual treatments. Nanotechnology brings new diagnosis hope for CNS disorders as it provides ultrasensitive detection for more specific biomarkers. Herein, the recent progress in techniques development for detecting pathological biomarkers for GBM, AD, and PD is summarized, in particular, the principles that govern the design of these sensors, blood–brain barrier (BBB) dysfunction, and its integrity during disease development. Finally, a perspective on future directions to further advance and improve the early‐stage diagnosis of CNS disorders is presented.

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“…Using fluorescent probes for long-term monitoring of live cells is the key to understanding and modulating molecular events happening within organelles, unraveling the physiological dynamics. Recently reported fluorogenic probes involve the D-A (donor–acceptor) type platforms such as substituted acetylnaphthalene derivatives ( Tang and Jiang, 2017 ; Zhang et al, 2021a ; Gao et al, 2021 ), BODIPYs ( Tian et al, 2018 ; Bai et al, 2019 ; Liu et al, 2019 ; Zhang et al, 2021b ; Li et al, 2021 ), AIEgens ( Shi et al, 2019 ; Xu et al, 2021 ; Zheng et al, 2021 ), and organometallic compounds ( Jin et al, 2021 ; Zhu et al, 2021 ; Ünlüer, 2021 ). However, tuning the bandgaps for predictable photophysical properties of D-A type molecules was limited by synthetic approaches.…”

Section: Introductionmentioning

confidence: 99%

Novel Pyrazine-Bridged D-A-D Type Charge Neutral Probe for Membrane Permeable Long-Term Live Cell Imaging

et al. 2021

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A novel donor–acceptor–donor (D-A-D) type compound containing pyrazine as the acceptor and triphenylamine as the donor has been designed and synthesized. The photophysical properties and biocompatibility of this probe, namely (OMeTPA)2-Pyr for live cell imaging were systematically investigated, with observed large Stokes shifts, high photostability, and low cytotoxicity. Furthermore, we demonstrated that (OMeTPA)2-Pyr could permeate live cell membranes for labeling. The proposed mechanism of this probe was the binding and shafting through membrane integral transport proteins by electrostatic and hydrophobic interactions. These salient and novel findings can facilitate the strategic design of new pyrazine-fused charge-neutral molecular platforms as fluorescent probes, for long-term in situ dynamic monitoring in live cells.

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Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease

Abstract: This review comprehensively summarizes various types of fluorescent probes for PD and their applications for detection of various PD biomarkers.

Cited by 112 publications

References 250 publications

Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

Nanotechnology‐Based Strategies for Early Diagnosis of Central Nervous System Disorders

Novel Pyrazine-Bridged D-A-D Type Charge Neutral Probe for Membrane Permeable Long-Term Live Cell Imaging

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