Floating matrix tablets based on low density foam powder: effects of formulation and processing parameters on drug release

Streubel, A.; Siepmann, J.; Bodmeier, Roland

doi:10.1016/s0928-0987(02)00223-3

Cited by 168 publications

(97 citation statements)

References 29 publications

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“…Extended-release dosage forms with prolonged residence times in the stomach are highly desirable for the drugs with narrow absorption windows, stability problems in the intestinal or colonic environments, locally acting in the stomach, and poor solubility in the intestine (Streubel, Siepmann, and Bodmeier 2003). Recent approaches to increase the gastric residence time of drug delivery systems include bioadhesive devices (Alvisi et al 1996;Ponchel and Irache 1998;Patel and Chavda 2009), swelling devices that increase their size (Urquhart and Theeuwes 1984;Mamajek 1980), low density devices (Streubel et al 2003;and Raval et al 2007), floating systems (Deshpande et al 1997 andDave et al 2004), high density systems (Bechgaard and Ladefoged 1978;Davis et al 1986), magnetic systems, unfoldable and expandable systems, magnetic systems, superporous, biodegradable hydrogel systems (Singh et al 2000) and microparticulate systems (Patel and Chavda 2009). The otherwise-excellent concept of floating system suffers from a disadvantage that it is effective only when the fluid level in the stomach is sufficiently high.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of glipizide floating-bioadhesive tablets

Patel¹,

Chavda

2010

Braz. arch. biol. technol.

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Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of glipizide floating-bioadhesive tablets

Patel¹,

Chavda

2010

Braz. arch. biol. technol.

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“…The effervescent components sodium bicarbonate was used for the generation of CO 2 gas. When the dosage form comes in contact with acidity of gastric contents, the CO 2 is entrapped in the polymeric network providing the floating characteristics to the dosage form [9][10][11].…”

Section: Kharwade Et Almentioning

confidence: 99%

“…The blend was lubricated with talc and magnesium stearate and compressed using 8 station compression machines. The tablet weighed for compression was adjusted to 400 mg [11].…”

Section: Formulation Of Floating Tablet Of Domperidone By Direct Compmentioning

confidence: 99%

Formulation and Evaluation of Gastroretentive Floating Tablet Using Hibiscus Rosa-Sinensis Mucilage

More¹,

Rs²,

Un³

2017

Asian J Pharm Clin Res

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Objective: Domperidone is a synthetic benzimidazole compound that acts as a dopamine D 2 receptor antagonist. The main aim of this study was to optimize and evaluate the floating tablets of domperidone that prolongs the gastric residence time using Hibiscus rosa-sinensis mucilage. Methods:The directly compressible floating tablets of domperidone were formulated using varying amount of hydroxypropyl methylcellulose K100 M, carbopol 934P and H. rosa-sinensis mucilage. The effervescent components sodium bicarbonate is used for the generation of CO 2 gas. The prepared tablets were evaluated for physicochemical parameters and found to be within range, viz., hardness, swelling index, floating capacity, thickness, and weight variation. Further, tablets were evaluated for in vitro release characteristics. The concentration of H. rosa-sinensis mucilage with a gas-generating agent was optimized to get the sustained release of domperidone. Result:The % cumulative drug release of all formulation from F1 to F6 was within the range of 81.37% to 98.62% for 18 hrs. The release kinetics of all the dosage forms was calculated using zero order, first order, Higuchi, and Korsmeyer-Peppas. It concludes that the release followed zero order release, whereas the correlation coefficient (r 2 value) was higher for zero order release. The release mechanism follows Higuchi model, KorsmeyerPeppas model, and non-Fickian diffusion. Conclusion:As a result of this study, it may be concluded that the floating tablets using H. rosa-sinensis mucilage in optimized concentrations can be used to increase the gastric retention time of the dissolution fluid in the stomach to deliver the drug in a sustained manner. Furthermore, from 1 month stability data shows no significant change compared to initial result.

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“…The granule formulation was carefully poured through a funnel until the apex of the conical pile just touched the tip of funnel. The height (h) of the pile of the powder and the radius (r) of its conical base were measured and applied to compute the angle of repose (θ) as in Eq 1 [14].…”

Section: Angle Of Reposementioning

confidence: 99%