Formulation and evaluation of glipizide floating-bioadhesive tablets

Patel, Jayvadan K.; Chavda, Jayant

doi:10.1590/s1516-89132010000500010

Cited by 6 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the effect of the polymer Badam gum was more pronounced than HPMC K4 M on bioadhesion strength since Badam gum has significant sticking property these findings are in agreement with previously reported results by Meka, et al, [23] who found the Badam gum has remarkable swelling and sticking character in gastric pH. [23][24][25][26][27][28][29][30][31][32][33] This developed floating-bioadhesive combination formulation would overcome the drawback of floating and bioadhesive individual system and improving the therapeutic effect of the drug involved.…”

Section: Bioadhesive Strengthsupporting

confidence: 90%

See 1 more Smart Citation

Untitled

Nawaj¹

2017

AJP

View full text Add to dashboard Cite

Aim: The objectives of this investigation were to develop gastroretentive floating bioadhesive drug delivery for simvastatin to increase gastric residence time and reduce the dose frequency. To explore Badams gum's sticking property in floating bioadhesive drug delivery of simvastatin. Materials and Methods: Floating bioadhesive tablet was formulated with Badam gum and hydroxypropyl methylcellulose (HPMC) K 15 M polymers, sodium bicarbonate, and citric acid as the gas generating agents to reduce floating lag time. Tablets were prepared by direct compression method. Optimization study was conducted using 3 2 factorial design. The concentration of polymers was considered as independent variables whereas swelling index, bioadhesive strength and % drug release at 10 h, of the tablets were utilized as dependent variables. Results and Discussions: Preformulation study suggests powders blends shows acceptable flow properties. Simvastatin floating-bioadhesive tablet found to be good without chipping, capping, and sticking. Comparing all the formulations, A5 optimized formulation exhibited 98.10 ± 2.10% of drug release in 12 h, floating lag time of 34 ± 3 s, with appropriate bioadhesive property, and total floating time of over 12 h. It was observed that increasing percentage of polymer in formulation the drug release decreased. Developed formulations were stable during stability studies. Conclusion: Based on these findings, it was concluded that Badam gum can be used as a bioadhesive as well as release retarding polymer for the floating bioadhesive dosage form of other drugs.

show abstract

Section: Bioadhesive Strengthsupporting

confidence: 90%

“…From this mucoadhesive strength, the force of adhesion, i.e., the force required for separating the tablet from the tissue surface was calculated using the following formula. [24][25][26][27][28][29][30][31] Force of adhesion N = Bioadhesive strength 9.81…”

Section: Si Studymentioning

confidence: 99%

Untitled

Nawaj¹

2017

AJP

View full text Add to dashboard Cite

show abstract

“…HPMC, pectin, carbopol, sodium bicarbonate and citric acid were weighed and passed through sieve number #40 individually. Powder mixing was carried out in a clean mortar and mixed thoroughly using a pestle [9]. Above powdered mixture was divided into two halves.…”

Section: Preparation Of Coat Layermentioning

confidence: 99%

Chronomodulated Mucoadhesive Gastroretentive Drug Delivery System of Famotidine

Chinthaginjala¹,

Ahad²,

Pradeepkumar³

2022

app

View full text Add to dashboard Cite

“…The solubility, dissolution, and eventually the bioavailability of GLZ can be improved by different techniques such as development of liquisolid tablets by using poly(ethylene glycol)-400 (PEG-400) as a liquid vehicle, polymeric microparticles, , polymeric nanoparticles, co-solvent solubilization approach, complexation of GLZ with α and β-cyclodextrins, − solid self-nanoemulsification, microemulsion technology, , preparation of osmotically controlled oral drug-delivery system, solid dispersion, − nanosuspension, microwave-generated bionanocomposites, transdermal drug-delivery system, floating bioadhesive drug-delivery system, and microcrystallization . The solubility data of GLZ in various neat solvents (NS) are scarce in research database.…”

Section: Introductionmentioning

confidence: 99%

Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents

et al. 2020

View full text Add to dashboard Cite

Glipizide (GLZ) is an oral hypoglycemic agent, which is a weakly aqueous soluble drug. The solubility values of GLZ in various neat solvents are scarce in the literature. Hence, the solubility of GLZ in 12 different neat solvents, namely, "water, methanol, ethanol, isopropanol (IPA), 1-butanol, 2-butanol, ethylene glycol (EG), propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), ethyl acetate (EA), dimethyl sulfoxide (DMSO), and Transcutol-HP (THP)", at "T = 298.2−318.2 K" and "p = 0.1 MPa" was measured. The recorded solubilities of GLZ were correlated by "van't Hoff and Apelblat models" using rootmean-square deviation (RMSD). The overall RMSD was obtained as 1.21 and 1.40% for "Apelblat and van't Hoff models", respectively. Different solubility parameters of all studied materials including drug and solvent were calculated to find the best solvent for GLZ. The solubilities of GLZ (expressed in mole fraction) have been found highest in DMSO (2.81 × 10 −2 ), followed by THP, EA, 2-butanol, 1-butanol, IPA, PEG-400, ethanol, PG, methanol, EG, and water (1.98 × 10 −4 ) at "T = 318.2 K". All investigated solubility parameters of GLZ were recorded very close to the DMSO. "Apparent thermodynamic analysis" showed an "endothermic and entropy-driven dissolution" of GLZ in the 12 different neat solvents. The highest molecular interactions were recorded in GLZ−DMSO compared to other combinations. Overall, DMSO has been considered as the best solvent for the solubilization of GLZ.

show abstract

Formulation and evaluation of glipizide floating-bioadhesive tablets

Abstract: ABSTRACT

Cited by 6 publications

References 35 publications

Untitled

Untitled

Chronomodulated Mucoadhesive Gastroretentive Drug Delivery System of Famotidine

Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents

Contact Info

Product

Resources

About