Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

Nanjwade, Basavaraj K.; Mhase, Sunil R; Manvi, F. V.

doi:10.4314/tjpr.v10i4.2

Cited by 20 publications

(15 citation statements)

References 21 publications

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“…The tablets were powdered, and an equivalent weight of 500 mg metformin was transferred into a 100 ml volumetric flask and shaken with 70 ml of distilled water for 15 minutes and further diluted with water to 100 ml and filtered. A quantity (1 ml) of filtered solution was diluted to 100 ml with water, and the amount of drug in each sample was analyzed using a validated HPLC method [ 30 , 31 ] with a Perkin Elmer Flexar HPLC with UV spectrophotometer at 232 nm. Each measurement was carried out in triplicate and the mean was taken.…”

Section: Methodsmentioning

confidence: 99%

Pectin from Okra (Abelmoschus esculentus L.) Has Potential as a Drug Release Modifier in Matrix Tablets

Boakye-Gyasi

Owusu

Entsie

et al. 2021

The Scientific World Journal

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Natural polymers have become attractive to pharmaceutical researchers and manufacturers as excipients because of the advantages they possess relative to their semisynthetic and synthetic counterparts. Although pectin from some natural sources has been investigated for use in the pharmaceutical industry as excipients, pectin from okra, which is readily available and used as food in many parts of the world, has not been extensively investigated as a potential control-releasing agent in tablets. This study thus seeks to determine the drug release modifying properties of okra pectin from 6 different genotypes of okra cultivated and available in Ghana. Pectin was extracted from different genotypes of okra, physicochemical properties were characterized, and control release matrix tablets of metformin (F1–F6) were formulated using the wet granulation method with the okra pectin as the drug release modifier, respectively. The drug content, in vitro drug release, and mathematical kinetic modeling of drug release from the matrix tablets were studied. Drug release profiles of formulated matrix tablets were compared to an existing (innovator) brand of metformin sustained-release tablet on the market using the similarity and difference factors, respectively. The extracted pectin had percentage yields ranging from 6 to 20% w/w with swelling indexes and water-holding capacities between 300–500% and 9-10 mL/g, respectively, and pH within 6.20–6.90. All the formulated batches passed the drug content test (90–105%) and produced the optimal release of metformin (>80%) after 24 hours. Different batches of formulated tablets exhibited different mechanisms of drug release with batches F1, F2, F5, and F6 being similar (ƒ2 values being >50 and ƒ1 values <15) to the innovator brand. Pectin from the 6 different genotypes of okra studied has the potential for use as drug release modifiers in pharmaceutical manufacturing of control release matrix tablets and production of more affordable medicines.

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Section: Methodsmentioning

confidence: 99%

Pectin from Okra (Abelmoschus esculentus L.) Has Potential as a Drug Release Modifier in Matrix Tablets

Boakye-Gyasi

Owusu

Entsie

et al. 2021

The Scientific World Journal

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“…An extended release tablet containing metformin was successfully prepared via melt granulation combining the hydrophobic stearic acid and hydrophilic poly(ethylene oxide). The matrix tablet formulation showed a controlled drug release profile 40 . Solid dispersions of metformin hydrochloride developed with methocel K100M were investigated also as alternative carrier for the antidiabetic molecule.…”

Section: Pharmaceutical Formulations For the Delivery Of Metforminmentioning

confidence: 99%

Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives

Okur¹,

Karantas²,

Sıafaka³

2017

actapharm

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“…Optimization of response factors was performed for minimizing the floating lag time FLT while maximizing the floating time and desired dissolution profile. The solution provided by the software with the greatest desirability was chosen as the optimum condition [18,19].…”

Section: Experimental Designmentioning

confidence: 99%

Development of Floating Gastroretentive Drug Delivery System Based on a Novel Excipient for Metformin Hydrochloride Using Mixture Design

Pawar

Jagdale

Randive³

2020

Int J Pharm Pharm Sci

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Objective: The present study aimed to develop a new SR metformin hydrochloride (MH) gastroretentive formulation with novel excipient (NE), which has better floatation and can be prepared with more simple pharmaceutical techniques for the treatment of diabetes Mellitus. Methods: A gastro-retentive floating matrix tablet (GFT) formulation of MH was prepared using various concentrations of PEO (Polyox WSR-303) and hydroxypropyl methylcellulose K100M (HPMC K100 M) and Floating agent (novel excipient) to achieve desirable TFT, FLT and drug release. The wet granulation method was selected using isopropyl alcohol as a binder for the preparation of tablets. D-optimal non-simplex mixture design was used for the selection of suitable polymer concentrations and floating agents. Release kinetics was used to determine the mechanism of drug release. Results: It was observed that GFT with optimum quantities of PEO, HPMC K100M, and the floating agent showed 100 % of drug release in 24h with FT up to 24h and minimum FLT of less than 2 min. Formulation with an in vitro release profile slower to the marketed sample was prepared. Conclusion: A sustained-release (GFT) of MH tablets using PEO-, HPMC K100M, and an effervescent system was successfully prepared. AGFT formulation with an in vitro release profile slower to the marketed sample that releases MH for 24h may suitable for once-daily dosing can be prepared.

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Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

Cited by 20 publications

References 21 publications

Pectin from Okra (Abelmoschus esculentus L.) Has Potential as a Drug Release Modifier in Matrix Tablets

Pectin from Okra (Abelmoschus esculentus L.) Has Potential as a Drug Release Modifier in Matrix Tablets

Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives

Development of Floating Gastroretentive Drug Delivery System Based on a Novel Excipient for Metformin Hydrochloride Using Mixture Design

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