Formulation and Evaluation of Gastroretentive Floating Tablet Using Hibiscus Rosa-Sinensis Mucilage

Abstract

Objective: Domperidone is a synthetic benzimidazole compound that acts as a dopamine D 2 receptor antagonist. The main aim of this study was to optimize and evaluate the floating tablets of domperidone that prolongs the gastric residence time using Hibiscus rosa-sinensis mucilage. Methods:The directly compressible floating tablets of domperidone were formulated using varying amount of hydroxypropyl methylcellulose K100 M, carbopol 934P and H. rosa-sinensis mucilage. The effervescent components sodium bicarbonate is used for the generation of CO 2 gas. The prepared tablets were evaluated for physicochemical parameters and found to be within range, viz., hardness, swelling index, floating capacity, thickness, and weight variation. Further, tablets were evaluated for in vitro release characteristics. The concentration of H. rosa-sinensis mucilage with a gas-generating agent was optimized to get the sustained release of domperidone. Result:The % cumulative drug release of all formulation from F1 to F6 was within the range of 81.37% to 98.62% for 18 hrs. The release kinetics of all the dosage forms was calculated using zero order, first order, Higuchi, and Korsmeyer-Peppas. It concludes that the release followed zero order release, whereas the correlation coefficient (r 2 value) was higher for zero order release. The release mechanism follows Higuchi model, KorsmeyerPeppas model, and non-Fickian diffusion. Conclusion:As a result of this study, it may be concluded that the floating tablets using H. rosa-sinensis mucilage in optimized concentrations can be used to increase the gastric retention time of the dissolution fluid in the stomach to deliver the drug in a sustained manner. Furthermore, from 1 month stability data shows no significant change compared to initial result.

Polymeric Excipients in the Technology of Floating Drug Delivery Systems

“…Xanthan gum [32] HPMC K 15M, NA [100] Egg albumin [46] EC, HPMC K4M [48] HPMC K4M, HPMC K100M, HPMC K100LV [52] HPMC K4M [53] NaCMC (2000 cP), HPMC K4M [56] HPMC K4M [101] HPMC E 15LV [102] HPMC K4 M, HPMC E5LV [103] HPMC K100 M CR [104] PEO (molecular mass: 1,000,000-7,000,000) [70] Carbomer (Carbopol 934), HPMC K4M [79] Carbomer (Carbopol 934P), HPMC K4M, HPMC E50 [80] HPMC K15 M, Carbomer (Carbopol 971 P NF), NaCMC [105] HPMC K15 M, EC, Gum [106] HPMC K4 M, Carbomer (Carbopol 974P) MA [107] HPMC K100 M, Mucus secreted from Hibscus rosa-sinensis, Carbomer (Carbopol 934P) MA [108] HPMC K4 M, HPMC K15 M, PEO (Polyox 303WSR) [109] NaCMC, PEO (Polyox 303WSR), Carbomer (Carbopol 934P) [110] HPMC K4 M, Locust bean gum [111] EC, HPMC K100 M [112] HPMC K15 M, Carbomer (Carbopol 971P) [75] NA, HPC [113] Carbomer (Carbopol 934P), NA, HPMC K4 M, PVP [114] HPMC K4 M, PVP K30 [115] Graft copolymer of polyacrylamide and corn fiber gum MA [116] Carbomer (Carbopol 934P), PEO (Polyox N-60K) [117] PEO (Polyox WSR205), Xanthan gum [118] HPMC K100 M, Carbomer (Carbopol 971P) [119] Tablets (wet granulation)…”