To Development and Evaluation of Aceclofenac Swellable Matrix Tablets Utilizing Okra (Abelmoschus Esculentus) and Hibiscus Leaf (Hibiscus Rosa-Sinensis) Natural Polymer Mucilage as Release Modifier. This study investigates the development of sustained-release Aceclofenac tablets using natural polymers, Okra Gum and Hibiscus Leaf Mucilage, to enhance drug efficacy, reduce dosing frequency, and minimize adverse effects in the treatment of inflammation and pain.: Sustained-release NSAID formulations using natural polymers like Okra Gum and Hibiscus Leaf Mucilage enhance drug efficacy, patient adherence, and safety by reducing dosing frequency and adverse effects. Non-steroidal anti-inflammatory drugs (NSAIDs), like Aceclofenac, are commonly prescribed for managing inflammation and pain associated with various conditions such as arthritis, musculoskeletal disorders, and post-operative recovery. Despite their effectiveness, traditional NSAIDs often exhibit rapid-release kinetics, necessitating frequent dosing intervals to maintain therapeutic efficacy. However, frequent dosing increases the risk of adverse effects such as gastrointestinal complications, renal impairment, and cardiovascular events. To address these challenges, sustained-release formulations have been developed to prolong drug action and reduce dosing frequency. Natural polymers, such as Okra Gum and Hibiscus Leaf Mucilage, have emerged as promising excipients for sustained drug delivery systems. These natural polymers offer several advantages, including biocompatibility, biodegradability, and the ability to modulate drug release kinetics. By incorporating Okra Gum and Hibiscus Leaf Mucilage into pharmaceutical formulations can improve patient adherence and therapeutic effectiveness while minimizing adverse effects. Fourier Transform Infrared analysis conducted as part of this study demonstrated no chemical interaction between Aceclofenac and the natural polymers, confirming their compatibility for formulation purposes. The formulated tablets met pharmacopoeial specifications for physicochemical properties, ensuring quality and consistency in manufacturing. The optimized formulation exhibited prolonged drug release lasting up to 12 hours, with release kinetics inversely proportional to polymer concentration. Stability studies conducted over a specified period indicated no significant changes in tablet attributes, affirming the robustness of the formulation. The findings of this study confirm the suitability of Okra Gum and Hibiscus Leaf Mucilage as effective release modifiers for Aceclofenac, offering potential benefits for sustained drug delivery in inflammation therapy. By providing valuable insights into the development of improved drug delivery systems using natural polymers, this research contributes to enhanced patient care and treatment outcomes in inflammatory conditions. Further exploration and optimization of natural polymer-based formulations hold promise for advancing drug delivery technologies and improving patient outcomes in clinical practice.
