Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention

Singh, Brahma N.; Kim, Kwon H.

doi:10.1016/s0168-3659(99)00204-7

Cited by 680 publications

(425 citation statements)

References 85 publications

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“…because the majority of drugs are preferentially absorbed in upper part of the small intestine (duodenum and jejunum) (Rouge et al 1996;Singh and Kim 2000). Furthermore, the relatively brief gastric emptying time in humans, which normally averages 2 to 3 hr through the major absorption zone (stomach and upper region of the intestine), can result in incomplete drug release from DDS leading to diminished efficacy of the administered of dose (Rubestein et al 1989).…”

mentioning

confidence: 99%

“…One attempt to overcome this problem is to extend the GI transit time of devices, by using floating dosage forms that have specific density lower than that of gastric fluids (1.004 g/cm 3 ) and remain buoyant in the stomach contents. The various buoyant preparations include hollow microspheres (microballoons), granules, powders, capsules, tablets (pills), and laminated films (Deshpande et al 1996(Deshpande et al , 1997Chien, 1997;Whiteheas et al 1998;Dressman 2000;Singh and Kim 2000).…”

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confidence: 99%

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Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

Junyaprasert

Pornsuwannapha

2008

Drug Delivery

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mentioning

confidence: 99%

mentioning

confidence: 99%

Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

Junyaprasert

Pornsuwannapha

2008

Drug Delivery

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“…(Singh & Kim, 2000;Streubel et al, 2006). The bulk density of FDDS is lower than that of gastric fluids and thus it remains buoyant on stomach contents for a long time in the drug releasing process.…”

Section: Preparation Of Intragastric Fdds By Plasma Techniquesmentioning

confidence: 99%

Cold Plasma Techniques for Pharmaceutical and Biomedical Engineering

Sasai¹,

Kondo²,

Yamauchi³

et al. 2011

Biomedical Engineering, Trends in Materials Science

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“…It helps to improves bioavailability, reduces drug wastage, improve solubility of drugs that are less soluble at high pH environment (e.g. weakly basic drugs like domperidone, papaverine) [2].…”

Section: Introductionmentioning

confidence: 99%

Development and in vivo evaluation of mucoadhesive tablets of Rebapimide

Gudas¹,

Jaswanth²,

Bhikshapathi³

2016

Int J of Biomed & Adv Res

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The aim of the present work was in vitro and in vivo evaluation of mucoadhesive tablets of rebapimide to prolong the gastric residence time after oral administration. The solubility of rebapimide was enhanced by kneading technique with that mixture formulations were prepared by using 3 3 full factorial designs to explore the effects of gum Kondagogu, gum Olibanum and Guar gum (as independent variables) on mucoadhesive strength, drug release and Ex vivo residence time (as dependent variables) was studied and published in the earlier research paper.In this investigation the formulated mucoadhesive tablets which was optimized through in vitro studies was selected and performed the in vivo studies on human volunteers. The drug-polymer interaction was also studied by conducting FTIR and DSC tests. The in vitro release kinetics studies reveal that all formulations fits well with zero order, followed by Korsmeyer-Peppas, Higuchi and the mechanism of drug release is erosion. After analysis of different evaluation parameters and drug release kinetics, formulation code F13 was selected as a promising formulation for delivery of rebapimide as a mucoadhesive gastroretentive tablet with best mucoadhesive strength and 99.34% drug release at 12 th hour. Radiological evidences suggest that, a formulated tablet was well adhered for >10 h in human stomach. The bioavailability studies of F13 containing rebapimide was carried out which exhibited increased pharmacokinetic parameters of Cmax (427.01±73), Tmax (4.00±1.23 h) and AUC 0-t (2242±18.24) as compared to marketed formulations which indicates improved bioavailability of formulations.

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Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention

Cited by 680 publications

References 85 publications

Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

Cold Plasma Techniques for Pharmaceutical and Biomedical Engineering

Development and in vivo evaluation of mucoadhesive tablets of Rebapimide

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