Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

Junyaprasert, Varaporn Buraphacheep; Pornsuwannapha, Supaporn

doi:10.1080/10717540802035335

Cited by 22 publications

(17 citation statements)

References 31 publications

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“…Kawashima et al (9) have proposed a system of hollow microspheres (microballoons) to increase the containment time of tranilast and ibuprofen in the stomach. Many studies have been published on the usage of microballoons to achieve FGS for modified release of drugs with different properties (16)(17)(18). Although orally administered water-soluble drugs may also present bioavailability problems, the systems of modified release have been proposed mostly for drugs of poor solubility in water (9,10,19).…”

Section: Introductionmentioning

confidence: 99%

“…The floating gastroretentive systems (FGS) are used to achieve gastric retention of orally administered solid dosage forms (7). The effectiveness and application of these systems have been evaluated in vitro and in vivo, and widely discussed (1,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Kawashima et al (9) have proposed a system of hollow microspheres (microballoons) to increase the containment time of tranilast and ibuprofen in the stomach.…”

Section: Introductionmentioning

confidence: 99%

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Development and Evaluation of a Floating Multiparticulate Gastroretentive System for Modified Release of AZT

et al. 2011

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Abstract. The aim of this study was to develop and evaluate a floating multiparticulate gastroretentive system for the modified release of zidovudine (AZT). AZT was used as a model drug water-soluble at therapeutic doses. The floating gastroretentive system was obtained by co-precipitation, after solvent diffusion and evaporation. The proposed system was evaluated in vitro for particle morphology, lag time and floating time, loading rate, release profile, and the release kinetic of AZT release. AZT's physicochemical characteristics were evaluated by differential scanning calorimetry (DSC), X-ray diffraction (XDR) and infrared spectroscopy (IR). The particles obtained were sphere-shaped, hollow, and had porous walls. The floating was immediate, and floating time was higher than 12 h. The loading rate was 34.0±9.0%. The system obtained had an extended release. DSC and XDR results showed a modification in AZT's solid state. IR spectroscopy revealed that the chemical structure of the AZT was unchanged. The hollow microballoons presented gastroretentive, floating, and extended-release properties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of a Floating Multiparticulate Gastroretentive System for Modified Release of AZT

et al. 2011

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“…The percentage of the production yield of the microparticles, percentage of drug content, and percentage of drug entrapment were calculated from the following equations [18]. and IR measurements were performed in transmission in the scanning range of 4000-400 cm -1 at ambient temperature.…”

Section: Characterization Of Glz-loaded Microparticlesmentioning

confidence: 99%

Development of Novel Controlled Release Gliclazide-Loaded poly(ε- caprolactone) Microparticles: Effect of Polymer Blends

Barakat¹,

Al-Shazli²,

Almedany³

2012

Pharm Anal Acta

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Gliclazide-loaded microparticles made with a polymeric blend were prepared by a solvent evaporation technique. Organic solutions of two polymers, poly (epsilon-caprolactone) (PCL) and Eudragit RS (E RS) or ethyl cellulose (EC), in different weight ratios, and 33.3% of GLZ were prepared and dropped into aqueous solution of poly vinyl alcohol, in different experimental conditions, achieving drug-loaded microparticles. The obtained microparticles were characterized in terms of yield of production, shape, size, surface properties, drug content, and in vitro drug release behavior. The physical state of the drugs and the polymer was determined by scanning electron microscopy (SEM), Fourier transform infra red and differential scanning calorimetry (DSC). Following the in vitro release studies microparticles made from blends of polymer, PCL/E RS or EC showed slower drug release than microparticles made from single PCL polymer. Surface morphology also revealed presence of porous and spherical structure of microparticles. Microparticles showing sustained release of GLZ were examined in rabbit and serum GLZ concentrations were calculated using HPLC method of assay.

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“…Microemulsions favor drug partitioning into skin by modifying the thermodynamic activity of the drug. This, along with altering the stratum corneum, allows for better drug delivery 14 . The low viscosity and Newtonian flow properties of microemulsions make them amenable to parenteral drug delivery 15 .…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, sterility validation, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications

Nesamony¹,

Zachar²,

Jung³

et al. 2012

Drug Development and Industrial Pharmacy

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Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

Cited by 22 publications

References 31 publications

Development and Evaluation of a Floating Multiparticulate Gastroretentive System for Modified Release of AZT

Development and Evaluation of a Floating Multiparticulate Gastroretentive System for Modified Release of AZT

Development of Novel Controlled Release Gliclazide-Loaded poly(ε- caprolactone) Microparticles: Effect of Polymer Blends

Preparation, characterization, sterility validation, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications

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