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The extract of the brown seaweed Padina boergesenii and the red seaweed Hypnea valentiae was found to detoxify (in vitro) the venom of Naja nigricollis. There was a remarkable reduction in the mortality of albino mice after intraperitoneal (i.p.) administration of reconstituted venom with the extract compared to those challenged with the venom only. The survival of the animals exposed to the venom incubated with the different concentrations of the extract was used as the in vitro detoxification parameter.

We conclude that probably due to presence of various phytochemicals plays an important role in the anti-venom potential of these Indian medicinal plants against Naja nigricollis venom. The above observations confirmed that A. paniculata, C. magna, G. superba and H. javanica plant extracts possess potent snake venom neutralizing capacity and could potentially be used as an adjuvants for antivenin therapy in case of snakebite envenomation, especially against the local effects of cobra venoms.

Topical conveyance of medications can be accomplished by fusing drug into the gel network for viable conveyance of medications. NSAIDs are non-steroidal medications having superb mitigating and pain-relieving action however NSAIDs produces GIT ulceration, liver and kidney inconvenience particularly if there should be an occurrence of oral organization. Hydrophilic polymers like carbopol-940 and HPMC K100 were used in an attempt to develop topical Emulgel formulations of Naproxen Evaluation tests for visual appearance, pH, consistency, spreadability test, in vitro prescription arrival of, in vivo medication release were performed. In vitro drug release ponders were finished by using Franz spread cell utilizing dialysis layer. The impacts of polymer, oil, surfactant and co surfactant piece on the rate of In vitro and in vivo medication discharge from the gel definitions were inspected through rodent stomach skin mounting on Franz dispersion cell at 37 ± 0.5oC. No conspicuous changes in physicochemical properties of definition were seen after its presentation to quickened states of temperature (40 ± 2oC) and mugginess conditions (75 ± 5% RH). Spreadability, pH and thickness esteems were observed to be marginally changed yet were tantamount with beginning qualities and the strength of the detailing was observed to be unaffected. The gel detailing, (F4) was observed to be reasonable for topical application dependent on in-vitro assessment and in-vivo pervasion thinks about. The optimized formulation, F4 was found to have great patient consistence on account of its simplicity of spreadability and the treatment was observed to be improved as the penetrability of the medication was enhanced.