Flexible agar-sericin hydrogel film dressing for chronic wounds

Tyeb, Suhela; Kumar, Nitesh; Kumar, Ashok; Verma, Vivek

doi:10.1016/j.carbpol.2018.08.030

Cited by 66 publications

(40 citation statements)

References 74 publications

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“…Wound dressings with high moisture content offers several benefits including, but not limited to, high malleability, easy and pain free removal of the dressing, cooling and soothing effect resulting in a sensation of pain reduction with a capability of developing a moist microclimate that has been proven to enhance epithelialisation [1,3,5,37,38]. The high moisture content in CUR:HPβCD-loaded-BC hydrogels produced in the current study would deliver these beneficial attributes and contributes towards facilitating wound healing along with patient comfort and compliance.…”

Section: Moisture Content (M C )mentioning

confidence: 99%

Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings

Gupta

Keddie

Kannappan

et al. 2019

European Polymer Journal

100

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Section: Moisture Content (M C )mentioning

confidence: 99%

Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings

Gupta

Keddie

Kannappan

et al. 2019

European Polymer Journal

100

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“…The hemocompatibility of PVA and PVA based sericin showed 0.04% and 0.19% respectively. This indicates that the synthesized films were nonhaemolytic and are highly suitable for wound dressings 20 .…”

Section: Antibacterial Assessment Of the Synthesized Filmmentioning

confidence: 78%

“…Swelling ratio (SR) % = SRW -SRD/SRD × 100 …. 2Haemo-compatibility: The biocompatibility of the synthesized film was done by ASTM F 756-00, 2000 (American Society for Testing and Materials) standard method 20 . The samples PVA and PVA based Sericin (PVA + S) film were kept in saline and equilibrated at 37 °C for 24 h. Then the samples were transferred into 7 ml of phosphate buffer and incubated at 37 °C for 3 days.…”

Section: Fourier Transform -Infra Red Spectroscopymentioning

confidence: 99%

Untitled

2019

IJPSR

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Sericin is a globular protein obtained from degumming of silk cocoon in the silk reeling process. The sericin film was synthesized for the application of antibacterial wound dressing, but it has a low physical property, hence the synthetic polymer was used in the synthesis of highly stable biocompatible film. The PVA based sericin film was prepared by solvent casting method by the addition of synthetic polymers-polyvinyl alcohol (PVA) to give the mechanical stability and the glycerol was added as a plasticizer. The characterization of PVA based sericin film for its antibacterial properties and the swelling ratio was evaluated. The PVA based sericin film showed significant antibacterial activity for wound pathogenic bacteria such as E. coli, S. aureus, K. pneumoniae, P. aeruginosa, and Proteus species and the swelling ratio of the film was 70% which indicates that the sericin has high moisture holding capacity which improves the wound healing process. The sericin film was also proved that it was biocompatible for biomedical applications. INTRODUCTION: Globally, wound infection becomes a major problem due to the resistance developed by the microorganisms. In the United States, every year approximately 5 lakhs people are infected by wound infection among 27 million surgeries. Roy et al., 1 stated that in Bangladesh more than 50% of people are affected by wound infection, among which 10-25% of postoperative infection. The following organisms mainly caused the wound infection: Staphylococcus aureus, Streptococcus pyogenes, Enterococci, Escherichia coli, Klebsiella pneumonia, Proteus species and Pseudomonas aeruginosa 2. It was reported that 62.9% of Gram-positive microorganisms and 37.1% of Gram-negative microorganisms were isolated 1 .

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“…When compared investigated curdlan-based dressings with others biomaterials dedicated for treatment of chronic wounds, it is clear that newly fabricated biomaterials have good ability to absorb liquids. For instance, the agar-sericin hydrogel film dressings dedicated for chronic wounds possessed swelling ratios that were around 320% [ 35 ], while the ability of alginate-pectin hydrogel films to absorb SWF was slightly above 250% [ 27 ]. Thus, these results indicate that porous curdlan-based biomaterials, especially Cur_Cu_6% as well as Cur_Cu_8% exhibit optimal liquid absorption capacity for wounds with moderate to high exudate levels.…”

Section: Resultsmentioning

confidence: 99%

Porous Curdlan-Based Hydrogels Modified with Copper Ions as Potential Dressings for Prevention and Management of Bacterial Wound Infection—An In Vitro Assessment

et al. 2020

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Bacterial infections at the wound site still remain a huge problem for current medicine, as they may lead to development of chronic wounds. In order to prevent such infections, there is a need to use wound dressings that possess ability to inhibit bacterial colonization. In this study, three new curdlan-based biomaterials modified with copper ions were fabricated via simple and inexpensive procedure, and their structural, physicochemical, and biological properties in vitro were evaluated. Received biomaterials possessed porous structure, had ability to absorb high amount of simulated wound fluid, and importantly, they exhibited satisfactory antibacterial properties. Nevertheless, taking into account all evaluated properties of new curdlan-based biomaterials, it seems that Cur_Cu_8% is the most promising biomaterial for management of wounds accompanied with bacterial infections. This biomaterial exhibited the best ability to reduce Escherichia coli and Staphylococcus aureus growth and moreover, it absorbed the highest amount of simulated wound fluid as well as enabled optimal water vapor transmission. Furthermore, Cur_Cu_8% biomaterial possessed the best values of selective indexes, which determine its potential safety in vitro. Thus, Cur_Cu_8% hydrogel may be considered as a promising candidate for management of infected wounds as well as it may constitute a good platform for further modifications.

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Flexible agar-sericin hydrogel film dressing for chronic wounds

Cited by 66 publications

References 74 publications

Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings

Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings

Untitled

Porous Curdlan-Based Hydrogels Modified with Copper Ions as Potential Dressings for Prevention and Management of Bacterial Wound Infection—An In Vitro Assessment

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