Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings

Gupta, Abhishek; Keddie, Daniel J.; Kannappan, Vinodh; Gibson, Hazel; Khalil, Ibrahim; Kowalczuk, Marek; Martin, Claire; Shuai, Xintao; Radecka, Iza

doi:10.1016/j.eurpolymj.2019.06.018

Cited by 94 publications

(70 citation statements)

References 55 publications

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“…The water content of the cellulose hydrogels was high. DPPH assay was used to determine the antioxidant activity of the hydrogels and the bacterial cellulose hydrogels loaded with curcumin displayed decreased oxidative stress at the wound site [ 69 ].…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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“…Cells in DMEM were used as a control. Cell viability was evaluated following the standard MTT assay, as previously reported [6].…”

Section: Cytotoxicity Assaysmentioning

confidence: 99%

“…Hydrogels, due to their similarity to natural tissue, are suitable for various biomedical applications, such as drug-delivery systems, scaffolds for tissue engineering, wound dressings, or contact lenses [5,6]. In addition, an important area of hydrogel application is personal-hygiene products such as nappies, sanitary pads, or adult-incontinence products [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Hydrogels Made of Poly-γ-Glutamic Acid (γ-PGA) for Potential Applications as Probiotic-Delivery Vehicles

et al. 2020

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Numerous hydrogels made of poly-γ-glutamic acid (γ-PGA) and various cross-linkers have been explored, but only limited data on hydrogels made of γ-PGA and poly(ethylene glycol) (PEG) are available. In this study, γ-PGA, a biodegradable and edible biopolyamide, was successfully cross-linked with selected PEGs to obtain a series of hydrogels. The swelling behaviour of these hydrogels was investigated under various pH conditions. It was also found that the structure of the cross-linker (linear or branched) affected the hydrogels’ swelling behaviour. In addition, in disc diffusion assay, hydrogel discs loaded with antibiotic were tested against Staphylococcus aureus and Escherichia coli. Prolonged activity of hydrogels loaded with antibiotics in comparison to paper discs containing antibiotics was observed. Moreover, the protective effect of hydrogels on entrapped probiotic cells subjected to low pH was investigated. The hydrogel swelling ratio and amount influenced the survival rate of the protected bacteria. Considering potential biomedical applications of hydrogels, cytotoxicity was evaluated towards two cell lines, MSTO and PANC 1.

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“…Being exceptionally patient-friendly, hydrogels promote healing by maintaining a moist environment at the wound site (donate moisture in the case of dry wounds and absorb water or biological fluids in excess in the case of exudative wounds). Moreover, they reduce pain through their cooling effect, allow gas exchange and can be loaded with antimicrobials and healing agents (Gupta et al, 2019;Moradi et al, 2020). However, the main limitation of hydrogels is their incompatibility with lipophilic substances, showing decreased loading strength and less control over the release mechanism of such drugs.…”

Section: Hydrogelsmentioning

confidence: 99%

“…Another possibility is to incorporate CD derivatives inside hydrogels, in order to form inclusion complexes with hydrophobic drugs. One such example is the complexation of curcumin (substance with wound healing ability, less likely than antibiotics to develop resistant strains) within hydroxypropylβ-CD (HPβCD) for enhancing the healing properties, physical performance, and cytocompatibility of the platform (Gupta et al, 2019;Kaolaor et al, 2019). Carboxymethyl cellulose (CMC)-based hydrogels can also benefit from the additivation with CDs.…”

Section: Hydrogelsmentioning

confidence: 99%

Cyclodextrins – development and applications of these versatile oligosaccharides

2020

Biomater Tissue Eng Bull

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. Cyclodextrins (CDs) are cyclic oligossacharides which have been known and studied for almost 130 years. This review aims to highlight the most important findings registered over this time, the physicochemical properties, preparation methods and uses of cyclodextrins, with special focus on their recently discovered applications. Due to their unique conformation, cyclodextrins are able to encapsulate a wide range of chemical entities, impacting on their solubility, bioavailability, stability, and shelf-life. Their complex formation properties together with the production from natural sources opens the door for cyclodextrins to be used in numerous and varied industries. However, the most important consumer of these versatile sugars is represented by the biomedical domain, where cyclodextrins find uses in drug formulations, delivery systems, medical textiles, implantable devices, tissue engineering, and many other connex applications. Moreover, intense research is still performed for this compounds, to develop and extend their therapeutic potential and serve as promising alternatives for treatment of severe diseases.

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Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings

Cited by 94 publications

References 55 publications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Synthesis of Hydrogels Made of Poly-γ-Glutamic Acid (γ-PGA) for Potential Applications as Probiotic-Delivery Vehicles

Cyclodextrins – development and applications of these versatile oligosaccharides

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