Flaxseed reduces plasma cholesterol and atherosclerotic lesion formation in ovariectomized Golden Syrian hamsters

Flaxseed Reduces Plasma Cholesterol Levels in Hypercholesterolemic Mouse Models

“…In summary, while flaxseed has been shown to reduce plasma cholesterol levels in rats [28] and hamsters [16], the current study is the first to show that the addition of 20% w/w whole ground flaxseed to a Western diet with the typical U.S. fatty acid profile and 0.1% cholesterol significantly reduces plasma non-HDL-C levels in hApoBtg mice, a mouse model with a lipoprotein profile similar to that of humans. Flaxseed also significantly reduced plasma cholesterol in the LDLr Ϫ/Ϫ / apobec Ϫ/Ϫ mouse, indicating that the hypocholesterolemic influence of flaxseed was independent of the LDLr and therefore, ruled out a major cholesterol clearance pathway.…”

“…A possible explanation may be due to the presence of endogenous sex hormones. In a previous study, ovariectomized hamsters have elevated TC and HDL-C levels relative to sham operated control females [16]. The addition of 7.5%-22.5% flaxseed to diets or estrogen injections reduced plasma TC and HDL-C levels of ovariectomized female hamsters back to those of sham operated animals.…”

Efeito da linhaça (Linum usitatissimum L.) sob diferentes formas de preparo na resposta biológica em ratos

“…O decréscimo do colesterol plasmá-tico pela administração do óleo de linhaça é relacionado com a diminuição do colesterol livre e do esterificado, e também com a n-6:n-3 32 . O efeito hipocolesterolêmico da linhaça tem importantes implicações terapêuticas em pacientes dislipidêmicos, sendo que estudos em humanos têm mostrado que o consumo de 40 a 50g/dia reduz o colesterol sérico entre 5% e 9% 32,34 . Sabe-se também que outros constituintes da linhaça, como lignanas, fibras e proteínas, também podem desempenhar um papel importante na redução do colesterol sérico, em animais e/ou humanos, e, além disso, alguns deles também podem atuar diretamente sobre as paredes de vasos e artérias, prevenindo a aterosclerose [18][19] .…”

Flaxseed Reduces Total and LDL Cholesterol Concentrations in Native American Postmenopausal Women

“…[20][21][22] Flaxseed has been reported to effectively lower cholesterol in postmenopausal women 20,[22][23][24][25] as well as in animal models. 26 We have reported that 40 g/day of flaxseed supplementation lowers (p Ͻ 0.05) both serum total cholesterol and non-high-density lipoprotein cholesterol (non-HDL-C) by 6% in primarily Caucasian postmenopausal women. Based on the positive findings of our previous studies, 24,25 the present study was designed to evaluate the extent to which the daily consumption of 30 g flaxseed improves lipid profiles in Native American postmenopausal women.…”