Flaxseed Reduces Total and LDL Cholesterol Concentrations in Native American Postmenopausal Women

Patade, Anagha; Devareddy, Latha; Lucas, Edralin A.; Korlagunta, Kiranmayi; Daggy, Bruce P.; Arjmandi, Bahram H.

doi:10.1089/jwh.2007.0359

Cited by 142 publications

(59 citation statements)

References 45 publications

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“…), and most of their health-related effects have been attributed to their activity as antioxidants [29,30]. A certain amount of data are now becoming available on the activity of these compounds at doses lower than those required to exert antioxidant activities, but sufficient to activate fundamental cell pathway-regulating metabolic functions [18,19,22,65,66]. Thus, the understanding of the possible health effect of lignans on the pathophysiological model of MetS has to go through the comprehension of their action as regulators of key factors that are central to metabolic pathway-regulating fat biosynthesis, fat storage and accumulation, glucose homeostasis, insulin biosynthesis and secretion, insulin sensitivity, cholesterol biosynthesis and secretion, and low chronic inflammation, which is the underlying contributor to the worsening of adipose metabolism and function [67,68].…”

Section: Discussionmentioning

confidence: 99%

“…Lignans are expected to have beneficial effects in humans after fermentative conversion in the colon to the mammalian lignans ENL and END [13,14]. Subpopulations with higher consumption of lignans display considerable lower disease frequency [7,[15][16][17][18][19][20][21][22]. In several studies, lignan-rich foods, concentrates or partially purified compounds have been shown to improve blood lipids, to enhance glycemic control and to alleviate or cure type 1 and type 2 diabetes [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

et al. 2014

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Purpose and background The focus was directed to the study of two of the most lignan-rich food sources: sesame and flaxseeds. Recent epidemiological and experimental evidences suggesting that these foods may improve metabolic functions underlying metabolic syndrome (MetS). Methods To characterize the effect of these oilseeds on metabolic functions, we conducted an experimental study aimed at preventing adiposity and metabolic imbalance in a mouse model of high-fat diet (HFD)-induced MetS. Statistical analysis was performed by two-way analysis of variance test followed by post hoc Bonferroni analysis. Results We studied the effect of the oilseeds sesame and flaxseed on metabolic parameters in mice on a HFD. When the HFD was integrated with 20 % of sesame or flaxseed flours, the mice showed a decrease in body fat, already at day 15, from time 0. The size of the adipocytes was smaller in epididymal fat, liver steatosis was inhibited, and insulin sensitivity was higher in mice on the supplemented diets. The supplemented diets also resulted in a significant increase in the serum levels of the lignan metabolites enterodiol and enterolactone compared with the controls. The expression of genes associated with the inflammatory response, glucose metabolism, adipose metabolism and nuclear receptor were altered by the oilseed-supplemented diets. Some of the most abundant lignans in these oilseeds were studied in 3T3-L1 preadipocyte cells and were effective in inhibiting adipocyte differentiation at the minimal dose of 1 nM. Conclusions The consumption of sesame and flaxseed may be beneficial to decrease metabolic parameters that are generally altered in MetS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

et al. 2014

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“…Whole ground flaxseed or the derivatized components of flaxseed have been shown to prevent atherosclerotic development under various conditions and in multiple animal models (15, 16, 25, 33-36, 38, 40). Dietary flaxseed has also exhibited beneficial effects in clinical studies on risk factors commonly associated with cardiovascular disease (7,21,26,32,38).…”

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confidence: 99%

The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat

Bassett

McCullough

Edel

et al. 2011

American Journal of Physiology-Heart and Circulatory Physiology

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“…Consumption of flaxseeds have shown to reduce total and LDL cholesterol as well as platelet aggregation 43,44 . The major bioactive components responsible for hypolipidemidic action of flaxseeds are dietary fiber, omega3 fatty acids and lignans and human trials related to these are discussed in detailed in table 5.…”

Section: Flaxseedsmentioning

confidence: 99%

Hypolipidemic Dietary Components

Madan

Narsaria

2013

Curr Res Nutr Food Sci

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Several prospective epidemiological studies over the past 20 years concluded that ingestion of certain food or dietary components improves serum lipid profile and are effective in management of hyperlipidemia. The objective of this paper is to identify and quantify selective lipid lowering dietary components. This review focuses on identifying, quantifying and understanding the possible mechanism of action of soy, flaxseeds, oats and psyllium in improving lipid profile and reducing atherosclerotic cardiovascular disease (ASCVD) risk factor. A systematic search of database was performed to retrieve studies of published human studies and trials from 1995-2012, concentrating on recent systematic reviews, meta-analysis and intervention trials done to further elucidate the role of selective food (soy, oats, flaxseeds and psyllium) and their bioactive components (soy protein, soy isoflavones, flaxseed lignan, flaxseed omega 3 fatty acid, b-glucan, insoluble fiber) involved in improving lipid profile and reducing the cardiovascular disease risks. The findings quantify the amounts showing beneficial effects on serum lipid profile. Overall, the review of these clinical evidences suggested that inclusion of these food items can moderately but significantly reduce the risk of dyslipidemia, when consumed regularly as a part of a healthy diet and thus may help reduce any untoward cardiovascular event

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Flaxseed Reduces Total and LDL Cholesterol Concentrations in Native American Postmenopausal Women

Abstract: The results of the present study indicate that Native American postmenopausal women benefit from regular consumption of flaxseed by reducing their risk of cardiovascular disease as seen from lowered LDL-C and total cholesterol levels.

Cited by 142 publications

References 45 publications

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat

Hypolipidemic Dietary Components

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