Flaxseed Reduces Plasma Cholesterol Levels in Hypercholesterolemic Mouse Models

Pellizzon, Michael; Billheimer, J T; Bloedon, LeAnne T.; Szapary, Philippe; Rader, Daniel J.

doi:10.1080/07315724.2007.10719587

Cited by 57 publications

(28 citation statements)

References 27 publications

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“…Diets based on saturated fats increase triglyceride levels, and despite the increased lipase activity, fat accumulates in the liver (PELLIZZON et al, 2008). In the present study, triglyceride levels were higher in G AF and lower in G C and G A (p < 0.05).…”

Section: Weight Evolutioncontrasting

confidence: 43%

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

et al. 2013

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This study evaluated the nutritional value of sesame and flaxseed oils and their effects on the lipid and glucose profile of rats fed diets containing different fat combinations. Fatty acid composition, refractive index, and iodine and saponification values were analyzed to characterize the oils. In the biological assay, Wistar rats were fed different diets, whose fat composition consisted of varying combinations of flaxseed oil, sesame oil, and animal fat. The primary constituents of the sesame oil were oleic (28.6%), linoleic (28.4%), and lauric acid (14.6%); for the flaxseed oil they were alpha-linolenic (39.90%), oleic (17.97%) and linoleic acid (12.25%). The iodine and saponification values of the oils were within the reference range. Rats fed flaxseed oil-based diets had the lowest serum cholesterol values, whereas rats fed diets with flaxseed oil + sesame oil + animal fat had the highest glucose levels. HDL levels decreased significantly with flaxseed oil. Sesame and flaxseed oils are sources of polyunsaturated fatty acids (PUFA), and the flaxseed oil-based diet had a hypocholesterolemic effect, whereas sesame oil showed oxidative stability since it contains high levels of monounsaturated and saturated fatty acids.

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Section: Weight Evolutioncontrasting

confidence: 43%

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

et al. 2013

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“…Flaxseed oil contains about 73% of polyunsaturated fatty acids (Cunnane et al 1993) among which, Ω-3 polyunsaturated fatty acids have been reported to increase pro-inflammatory cytokine production at wound sites and accordingly promote cutaneous wound healing (McDaniel et al, 2008). Furthermore, linseed is rich in fatty acids such as α-linolenic acid (the major one 39-60%), oleic, linoleic, palmitic and stearic acids (Pellizzon et al, 2007). Oleic, linoleic and α-linolenic acids supply cells with lipids necessary for their membrane repair and their respiration (Loden and Andersson, 1996).…”

Section: Discussionmentioning

confidence: 99%

EVALUATION OF CRUDE FLAXSEED (Linum usitatissimum L.) OIL IN BURN WOUND HEALING IN NEW ZEALAND RABBITS

Beroual¹,

Agabou²,

Abdeldjelil³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Burns are among the most prevalent injuries in humans with high cost in health care and heavy prolonged or permanent physical, psychological and social consequences. Commercial antimicrobial creams and dressing agents are unsuccessful in healing deep burn wounds. Materials and Methods: A study was conducted to assess the impact of crude linseed oil (LSO) topical application on burn wounds healing in rabbits in comparison with untreated wounds (NAT) and those treated with Vaseline gel (VAG) and Cicatryl-Bio ointment (CBO). By the 28 th day post burning, skin biopsies were analyzed for histological and cytological lesions. The presence of various bioactive phytochemical groups in linseed was also screened. Results: Phytochemical screening has resulted in high concentrations of flavonoids and terpenoids, low amounts of catechic tannins and total absence of alkaloids and saponosides. All along the trial, the rate of wounds contraction was found to be significantly higher in burns treated with LSO which had also a significant shorter healing period (26±5.89 days) as compared to the other treatments. LSO healed wounds included less inflammatory cells, complete epithelium regeneration with a reduced thickness of the new formed dermis, discreet fibrosis, enhanced neo-vascularization, increased number of collagen fibers, fibroblasts and many myofibroblasts. Additionally, no adverse effects of LSO on cicatrization process were recorded. Conclusion: These findings prove the safety and efficaciousness of linseed oil topical application in the therapy of burn wounds.

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“…In hypercholesterolemic animal models, the potential atheroprotection of ALA has been mainly investigated by using whole fl axseeds (11)(12)(13). However, as stated in a recent review by Prasad, suppression of atherosclerosis by fl axseed is likely more attributable to the lignan content of fl axseed rather than ALA ( 14 ).…”

Section: Quantifi Cation Of Mrna Levelsmentioning

confidence: 99%

Dietary n-3 LCPUFA from fish oil but not α-linolenic acid-derived LCPUFA confers atheroprotection in mice

Degirolamo

Kelley

Wilson

et al. 2010

Journal of Lipid Research

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LCPUFA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) to cardioprotection ( 1, 2 ). As a consequence, increased consumption of food-based sources of EPA and DHA has been recommended in most nutritional guidelines issued by government and health organizations, such as American Heart Association ( 3 ). Although oily fi sh is the richest dietary source of EPA and DHA, its consumption in most Western countries is low and inadequate to provide the recommended daily intake (250-500 mg of EPA and DHA) ( 3 ). Vegetable oils, such as fl axseed, soybean, and canola oil, and nuts, such as English walnuts, that are enriched in ␣ -linolenic acid (ALA) can serve as alternative sources of EPA and DHA. ALA is referred to as the essential precursor of n-3 LCPUFA because its further elongation and desaturation leads to the formation of EPA and DHA ( 4 ). However, the rate of conversion of ALA to EPA is low ( ‫ف‬ 5%) and to DHA even lower (<1%) and can be modifi ed by several factors, such as dietary cholesterol, n-6 PUFA intake, and gender-related hormones ( 5 ).The atheroprotective potential of ALA has been questioned for a long time but not yet extensively investigated. To date, studies in humans have reported that (a) ALA supplementation results in its rapid incorporation into lipoproteins and elevated plasma ALA, EPA, and docosapentaenoic acid (DPA) but not DHA concentrations ( 6, 7 ); (b) ALA intake is inversely associated with nonfatal acute

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Flaxseed Reduces Plasma Cholesterol Levels in Hypercholesterolemic Mouse Models

Cited by 57 publications

References 27 publications

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

EVALUATION OF CRUDE FLAXSEED (Linum usitatissimum L.) OIL IN BURN WOUND HEALING IN NEW ZEALAND RABBITS

Dietary n-3 LCPUFA from fish oil but not α-linolenic acid-derived LCPUFA confers atheroprotection in mice

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