Flaxseed oil: an emerging nutraceutical decimates cisplatin-induced submandibular salivary glands damage in rats

Labah, Doaa A; Wahba, Omneya M

doi:10.4103/tdj.tdj_7_17

Cited by 3 publications

(2 citation statements)

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“…In a histological and ultrastructural study, Labah et al [4] reported that cisplatin injection had adversely affected the histological structure of the rats' SMGs. In their study, signs of acini degeneration represented by disfigured lobular structure and loss of normal architecture of the secretory portions were observed.…”

Section: Discussionmentioning

confidence: 99%

“…Saliva and salivary glands are also adversely affected by chemotherapy toxicity. Chemo-therapeutic drugs can cause morphological damage to the salivary glands [4,[15][16][17]. In patients treated with chemo-therapeutic drugs, living conditions deteriorates because of the side effects, such as the symptom of dry mouth commonly associated with the hypofunction of salivary glands, taste disorder (hypogeusia), and swallowing problems, saliva being susceptible to candida infections due to the decrease in its' anti-microbial potential [18][19][20][21][22][23][24].…”

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confidence: 99%

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Effects of chemo-therapeutic drugs used in head and neck cancers on sub-mandibular glands of rats

Yurdabakan¹,

Özcan²,

Solakoğlu³

2022

jos

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Introduction: Chemo-therapeutic drugs can cause morphological damages to the salivary glands.Objectives: This study aimed to analyze and elucidate 5-fluorouracil (5-FU), cisplatin, methotrexate (MTX), and adriamycin (ADR)-induced morphological changes on submandibular glands (SMGs) of the rats. Material and methods: Forty male Wistar albino rats were divided into five groups, with 8 rats per group. In the control group, 1 ml/kg 0.9% sterile saline solution; in the second group, 100 mg/kg dose of 5-FU; in the third group, 5 mg/kg dose of cisplatin; in the fourth group, 15 mg/kg dose of MTX; in the fifth group, 15 mg/kg dose of ADR were injected once a day for three consecutive days intra-peritoneally. In all groups, SMGs were excised, histopathological analyses were done using a light microscope, and total protein content was analyzed according to Lowry method. Data were examined using analysis of variance (ANOVA), Tukey HSD, Kruskal-Wallis, and Dunn's tests. Results were evaluated at 95% confidence interval and significance level of p < 0.05. Results: There was a statistically significant decrease in gland weight and total protein content of the 5-FU, ADR, and cisplatin groups compared to that of the control (p < 0.001). However, the decrease in gland weight and total protein content of MTX group was not statistically significant (p > 0.05). Acinus areas of 5-FU, ADR, cisplatin, and MTX groups were lower than that of the control significantly (p < 0.001). Conclusions: According to morphological parameters of our study, the most toxic effects were found to be caused by 5-FU, followed by ADR and cisplatin, while MTX presented the least toxic effects on the rats' SMGs.

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Section: Discussionmentioning

confidence: 99%