Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer

Inhibitory activity of flaxseed oil against CdCl2 induced liver and kidney damage: Histopathology, genotoxicity, and gene expression study

“…Consumption of FO for 28-days improved the lipid and glucose profile, reduced cardiac, hepatic and renal markers, reduced oxidative damage and stimulated the antioxidant defense system in patients with metabolic syndrome [ 15 ]. Recently, treatment with FO reduced cell proliferation in several human cancers and reduced tumor growth in an ectopic cervical cancer mouse model [ 16 , 17 ]. Although the prophylactic activity of FO has been demonstrated, its protective mechanism is complex and still incompletely understood.…”

Physical Activity of ≥7.5 MET-h/Week Is Significantly Associated with a Decreased Risk of Cervical Neoplasia

“…It was found that HR-HPV infection and tobacco exposure were essential risk factors for developing CIN, particularly for HR-HPV infection which predominantly leads to progression to invasive cervical cancer [ 5 , 29 , 30 , 31 ]. The Th1 immune response plays an important role in protecting against the E6 and E7 oncoproteins of HPV 16 and 18 infection and failure of E6-specific Th1 immunity is highly associated with the persistence of HPV infection and CIN progression [ 29 , 30 ]. Th1 cytokines, such as IFN-α and IFN-β, are pivotal in interfering with HPV transcription and activating innate and adaptive immunity [ 30 ].…”

Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy

“…In addition to luteolin, several novel flavonoids were also identified in the process with a promising therapeutic role in cervical cancer. Several plant extracts and products like latex from Ficus carica, seed oil from flax, or the stem extracts of Cudrania tricuspidata also showed anti-oncogenic potential as they could bring down the expression of E6 and E7 transcripts and proteins, with a concomitant apoptotic conclusion (Kwon et al, 2016;Deshpande et al, 2019;Ghanbari et al, 2019). The use of natural products promises a comparatively safer alternative therapeutic approach to cervical cancer.…”