Fish oil protects the peripheral and central nervous systems against cisplatin-induced neurotoxicity

Kamışlı, Suat; Çiftçi, Osman; Çetin, Aslı; Kaya, Kürşat; Kamışlı, Özden; Çelik, Hamit

doi:10.1179/1476830513y.0000000074

Cited by 11 publications

(5 citation statements)

References 35 publications

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“…The mechanism of CP inducted neurotoxicity is still unknown exactly but past studies indicated that CP direct connects with neuronal DNA and increases formation of reactive oxygen species (ROS) 4,5 . In accordance, our previous studies showed that CP leads to oxidative damage on the nervous system 6,7 the beneficial effect of hesperidin (HP. Therefore, many antioxidant compounds such as selenium 8 , D-Methionine 9 were tried with a view to can prevent CP induced oxidative damage on the nervous system.…”

Section: Introductionsupporting

confidence: 87%

“…Also Turan et al 28 reported that CP treatment led to increase 200% TBARS and myeloperokxidase in addition to decrease 60% SOD and GSH approximately. Alike, our previous studies showed that CP caused significantly increased TBARS level and decreased GSH, SOD, CAT and GPx levels on the nervous system 6,7 . In the present study detected that TBARS level of CP group increased significantly compared with other groups, suitable for our expectation.…”

Section: Discussionmentioning

confidence: 72%

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Beneficial effects of β-glucan against cisplatin side effects on the nervous system in rats 1

et al. 2016

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Section: Introductionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 72%

Beneficial effects of β-glucan against cisplatin side effects on the nervous system in rats 1

et al. 2016

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“…[10] and Kamisli et al . [11] where CP causes neurotoxicity in rats at doses ranged from 2 mg/kg to 7 mg/kg, respectively.…”

Section: Methodsmentioning

confidence: 99%

Azadirachta indica attenuates cisplatin-induced neurotoxicity in rats

Moneim

2014

Indian J Pharmacol

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Objective:The objective of this study is to investigate the neuroprotective effects of Azadirachta indica leaves against cisplatin (CP)-induced neurotoxicity.Materials and Methods:Female Wistar rats were treated with vehicle (control); a single intraperitoneal 5 mg/kg CP (CP group); neem leaves (orally 500 mg/kg) for 5 and 10 days, N5 and N10 groups, respectively; neem leaves (500 mg/kg) for 5 days after CP injection, collagenous protein nitrogen (CPN) group; neem leaves (500 mg/kg) for 5 days before CP injection, noncollagenous protein group and neem leaves in a dose of 500 mg/kg for 5 days before and after CP injection, noncollagenous protein nitrogen group. Rats were sacrificed 5 days after CP injection to determine neural lipid peroxidation (LPO), nitric oxide (NO), and glutathione (GSH) levels. The neuronal antioxidant enzymes were evaluated in brain homogenates.Results:CP injection increased LPO, NO levels and decreased GSH level, whereas neem reversed these effects. Morphological brain damage and apoptosis induction were apparent in the CP group. In the CPN group, the histological damage and apoptosis induction caused by CP was improved, whereas morphological findings of neem before and after CP injection implied a well preserved brain tissue. No changes, in biochemical parameters were observed with neem treated groups.Conclusion:This study suggests that methanolic extract of neem leaves may be of therapeutic benefit when used with CP.

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“…Currently many chemo protective agents such as erythropoietin, fish oil, valproate, vitamin E, melatonin and alpha lipoic acid were used to reduce or prevent the neurotoxic effect of the cisplatin in various in vivo and in vitro studies through different cellular targets [13][14][15][16][17][18] . However, to our knowledge, there is not any previous study which investigated whether selenium can reduce or prevent cisplatin induced central neurotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Selenium protects cerebral cells by cisplatin induced neurotoxicity

et al. 2015

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PURPOSE:To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium. METHODS:Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12 mg/kg/day, i.p.) was administered to CS and CSE groups for three days. Furthermore, CSE group received 3mg/kg/day (twice-a-day as 1.5 mg/kg) selenium via oral gavage five days before cisplatin injection and continued for 11 consecutive days. The same volumes of saline were administered to C group intraperitoneally and orally at same time. RESULTS:Heterochromatic and vacuolated neurons and dilated capillary vessels in the brain were observed in the histochemical examinations of cisplatin treated group. Rats that were given a dose of 3mg/kg/day selenium decreased the cisplatin induced histopathological changes in the brain, indicating a protective effect. In addition, cytoplasmic staining of the cell for bcl-2, both cytoplasmic and nuclear staining for bax were determined to be positive in the all groups. Bax positive cells were increased in the CS group compared to C group, in contrast to decreased bcl-2 positivity.CONCLUSION: Selenium limited apototic activity and histological changes due to the cisplatin related central neurotoxicity.

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Fish oil protects the peripheral and central nervous systems against cisplatin-induced neurotoxicity

Abstract: CP has severe central and peripheral neurotoxic effects in rats and these effects were largely prevented by FO treatment. Thus, it appears that co-administration of FO with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.

Cited by 11 publications

References 35 publications

Beneficial effects of β-glucan against cisplatin side effects on the nervous system in rats 1

Beneficial effects of β-glucan against cisplatin side effects on the nervous system in rats 1

Azadirachta indica attenuates cisplatin-induced neurotoxicity in rats

Selenium protects cerebral cells by cisplatin induced neurotoxicity

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