Beneficial effects of β-glucan against cisplatin side effects on the nervous system in rats 1

Kaya, Kürşat; Çiftçi, Osman; Çetin, Aslı; Tecellioğlu, Mehmet; Başak, Neşe

doi:10.1590/s0102-865020160030000008

Cited by 17 publications

(23 citation statements)

References 30 publications

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“…The origin of β‐glucan is organic complex molecules which obtained from cereal and yeast species (Kaya, Ciftci, Cetin, Tecellioglu, & Basak, ). Previous studies have shown that β‐glucan has various activities, such as immunomodulation and anti‐oxidation (Dietrich‐Muszalska, Olas, Kontek, & Rabe‐Jablonska, ).…”

Section: Introductionmentioning

confidence: 99%

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

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Three hundred Oreochromis niloticus were divided into five groups; the control fish (CNT) were fed a basal diet, beta glucan (βG) group was fed 0.5 g/kg−1 βG, atrazine (ATZ) group was exposed to 1/5 96‐hr LC50 (1.39 mg/L) ATZ, the (βG/ATZ) group was fed βG while being exposed to ATZ, and the (βG then ATZ) group was supplemented with βG for fifteen days before exposed to ATZ. ATZ exposure caused a decline in growth that was ameliorated by βG. ATZ reduced the levels of total and different types of leucocytes. Additionally, ATZ exposure caused reductions in total proteins, globulins, α 1‐globulin, α 2‐globulin, ɤ‐globulin, immunoglobulin M, lysozymes, superoxide dismutase, nitric oxide and catalase but increases in hepatic transaminases and malondialdehyde without any variations in albumin and β‐globulin. Exposure to ATZ also resulted in a rise in the mRNA level of IL‐8. In contrast, expression of IgM, SOD and CAT were decreased in the tilapias exposed to ATZ. Exposure to ATZ increases the susceptibility response to Aeromonas sobria challenge, as indicated by an increase in cumulative mortality post‐challenge. Supplementation with βG fifteen days before (βG then ATZ group), counteracted the adverse effects of ATZ on the immune, biochemical and antioxidants values, though only slight alleviation was observed with simultaneous treatment (βG/ATZ group). Our results established that ATZ has adverse impacts on immune responses, antioxidant equilibrium and its related genes. While, supplementation with βG before exposure to ATZ may be valuable for counteracting the possible damage caused by ATZ water pollution than its simultaneous treatment with ATZ.

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Section: Introductionmentioning

confidence: 99%

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

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“…The clinical usage of CP is restricted due to its severe dose‐dependent side effects (Bayindir et al, ; Eid, Abdelkader, Abd El‐Raouf, Fawzy, & El‐Denshary, ). Previous research showed that CP treatment caused damage to many tissues and organ systems, such as reproductive toxicity (Kaya et al, ), nephrotoxicity (Masuda, Inoue, Miyata, Mizuno, & Nanba, ), hepatotoxicity (Ciftci, Onat, & Cetin, ), ototoxicity (Bayindir et al, ), ocular toxicity (Taşlı et al, ) and neurotoxicity (Kaya, Ciftci, Cetin, Tecellioğlu, & Başak, ). Many previous studies on CP‐induced male reproductive system toxicity demonstrated that CP administration led to oxidative damage and apoptosis in testicular tissue, a decline in testes' weight, an increase in abnormal sperm rate and a decrease in sperm concentrations and motility (Aksu et al, ; Ciftci et al, ; Kaya et al, ; Saral et al, ).…”

Section: Introductionmentioning

confidence: 99%

Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

et al. 2019

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The aim of this study was to investigate the potential beneficial effects of β‐glucan treatment against oxidative, histological and spermatological damage caused by cisplatin on the male reproductive system. Twenty‐eight Sprague Dawley male rats were used in the study. The rats were randomly divided into four equal‐sized groups: a control group, cisplatin group (7 mg/kg in a single‐dose cisplatin administered intraperitoneally), β‐glucan group (β‐glucan given at a dose of 50 mg kg−1 d−1 for 14 day) and a cisplatin plus β‐glucan group (cisplatin and β‐glucan administered together at the same dose). Cisplatin administration induced an increase in the level of thiobarbituric acid‐reactive substances, a lipid peroxidation indicator. It induced a decrease in enzymatic (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic (reduced glutathione) antioxidant levels. In addition, cisplatin caused both histological and spermatological damage, as shown by a decrease in sperm motility and epididymal sperm concentrations and an increase in abnormal sperm rates. The β‐glucan treatment improved cisplatin‐induced oxidative, histological and spermatological damage. This study revealed that β‐glucan treatment provided prevention against male reproductive system damage caused by cisplatin. These preventative effects were likely due to its antioxidant properties.

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“…(1 → 3)‐β‐D‐glucan is one of the antioxidant agents which possess therapeutic value in alleviating various organ injuries (Şener, Ekşioğlu‐Demiralp, Çetiner, Ercan, & Yeğen, ). Besides, (1 → 3)‐β‐D‐glucan reduces the side effects of various chemotherapy drugs (Kaya, Ciftci, Cetin, Tecellioğlu, & Başak, ; Schwartz & Hadar, ). However, in our study, instead of suppressing the toxic side effects of bortezomib, (1 → 3)‐β‐D‐glucan enhances its toxicity by decreasing the antioxidant enzyme levels, increasing the immunoreactivity of NF‐κB, and causes histopathological changes in the rat testis.…”

Section: Discussionmentioning

confidence: 99%

“…Wang et al observed that (1 → 3)‐β‐D‐glucan reduced LPO levels in their work (Wang et al, ). Kaya, Ciftci, Cetin, Tecellioğlu, & Başak demonstrated that chemotherapy drug administration with (1 → 3)‐β‐D‐glucan reduced the level of LPO and neurotoxicity (Kaya et al, ). Similarly, Erkol et al showed that beta‐glucan decreased LPO levels and liver damage (Erkol et al, ).…”

Section: Discussionmentioning

confidence: 99%

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(1 → 3)‐β‐ d ‐glucan enhances the toxicity induced by Bortezomib in rat testis

et al. 2020

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We aimed to determine the possible effects of the antioxidant agent (1 → 3)‐β‐D‐glucan on bortezomib‐induced rat testis damage. We used five groups of rats; control, (1 → 3)‐β‐D‐glucan (75 mg/kg), bortezomib group, bortezomib + (1 → 3)‐β‐D‐glucan groups (injection of (1 → 3)‐β‐D‐glucan after bortezomib and sacrificed at 48th or 72nd h). The effects of these substances were assessed by measuring the levels of the antioxidant enzymes and LPO, and by performing immunohistochemical analysis with NF‐κB. The histology of testis was evaluated using aniline blue staining. (1 → 3)‐β‐D‐glucan leads to significant reductions in the levels of antioxidant enzymes and increased levels of LPO in testes. Moreover, it increased the NF‐κB immunopositivity significantly in testis, especially in Bortezomib + (1 → 3)‐β‐D‐glucan group at 48th h. The histological changes were observed in the bortezomib and/or (1 → 3)‐β‐D‐glucan groups. Our results demonstrated that testis damage caused by the treatment with bortezomib was not eliminated by (1 → 3)‐β‐D‐glucan and shockingly it increased the damage. Practical applications The testis damage caused by the treatment with bortezomib was not eliminated by (1 → 3)‐β‐D‐glucan and as a result, β‐1,3‐(D)‐glucan enhanced the toxicity by leading a decrease in the levels of GSH, SOD, and CAT, thus caused an elevation in the immunoreactivity of NF‐κB and altered the histopathological changes by enhancing the toxic effects of bortezomib. The findings of the previous studies about the antioxidative activity of (1 → 3)‐β‐D‐glucan are controversial. So, it is necessary to consider the cytotoxicity of (1 → 3)‐β‐D‐glucan in testis tissue. Thus, more studies on testis tissue are necessary to confirm that (1 → 3)‐β‐D‐glucan is safe as an antioxidant.

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Beneficial effects of β-glucan against cisplatin side effects on the nervous system in rats 1

Abstract: Cisplatin has severe neurotoxic effects in rats and βg supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that βg might be useful against CP toxicity in patients with cancer in terms of nervous system.

Cited by 17 publications

References 30 publications

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

(1 → 3)‐β‐ d ‐glucan enhances the toxicity induced by Bortezomib in rat testis

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