Azadirachta indica attenuates cisplatin-induced neurotoxicity in rats

Moneim, Ahmed E. Abdel

doi:10.4103/0253-7613.132182

Cited by 42 publications

(22 citation statements)

References 24 publications

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“…The NO radicals play a crucial role in inducing inflammatory response, and their toxicity propagated only when they react with O 2 •− radicals to form peroxynitrite, which damages biomolecules such as proteins, lipids, and nucleic acids [ 43 ]. In the present study, we showed that pomegranate juice restrained NO generation, thus suggesting its applicability as a potent and novel therapeutic agent for scavenging NO.…”

Section: Discussionmentioning

confidence: 99%

Pomegranate (Punica granatum) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Stress in Female BALB/c Mice

Alkathiri

El‐Khadragy

Metwally

et al. 2017

IJERPH

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Leishmania species are parasites that multiply within phagocytes and cause several clinical diseases characterized by single or multiple ulcerations. One of the complications that can induce tissue damage and the resulting scars is caused by secondary bacterial infections. Studies to find new, effective, and safe oral drugs for treating leishmaniasis are being conducted since several decades, owing to the problems associated with the use of antimonials available. Previously, the antiparasitic and antioxidant properties of Punica granatum (pomegranate, P. granatum) have been reported. Therefore, in the present study, we aimed to investigate the antileishmanial activity of pomegranate aqueous juice in vitro and in female BALB/c mice. A 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in Leishmania major promastigotes and alterations in the antioxidant status, liver function, and skin histological changes in L. major-infected mice orally treated with pomegranate juice alone and in combination with the antibiotic ciprofloxacin, were used to investigate the in vitro and in vivo antileishmanial activity of pomegranate juice, respectively. Oral P. granatum juice treatment significantly reduced the average size of cutaneous leishmaniasis lesions compared with that of the untreated mice. This antileishmanial activity of P. granatum was associated with enhanced antioxidant enzyme activities. Histopathological evaluation proved the antileishmanial activity of P. granatum, but did not reveal changes in the treated animals, compared to the positive control. In conclusion, P. granatum shows high and fast antileishmanial activity probably by boosting the endogenous antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Pomegranate (Punica granatum) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Stress in Female BALB/c Mice

Alkathiri

El‐Khadragy

Metwally

et al. 2017

IJERPH

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“…It is an alkylating agent which at effective higher doses causes many adverse effects such as neurotoxicity, nephrotoxicity, and genotoxicity [12, 30]. CP-induced nephrotoxicity can result in severe renal tubular injury leading to acute renal failure [31].…”

Section: Discussionmentioning

confidence: 99%

Azadirachta indicaAttenuates Cisplatin-Induced Nephrotoxicity and Oxidative Stress

Moneim

Othman

Aref

2014

BioMed Research International

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We investigated the effects of methanolic leaves extract of Azadirachta indica (MLEN, 500 mg/kg bwt) on cisplatin- (CP-) induced nephrotoxicity and oxidative stress in rats. CP (5 mg/kg bwt) was injected intraperitoneally and MLEN was given by gastric gavage for 5 days before or after CP injection. After 5 days of CP injection, CP-induced injury of the renal tissue was evidenced (i) as histopathological damage of the renal tissue, (ii) as increases in serum uric acid, urea, and creatinine, (iii) as increases in malondialdehyde (MDA) and nitric oxide (NO), (iv) as decreases in the level of glutathione and activities of superoxide dismutase, catalase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase, and (v) as increase in the expression of nuclear factor kappa B and apoptosis in kidney tissues. However, the oral administration of MLEN to CP-intoxicated rats for 5 days brought back MDA, NO production, and enzymatic and nonenzymatic antioxidants to near normalcy. Moreover, the histological observations evidenced that neem extract effectively rescues the kidney from CP-mediated oxidative damage. Furthermore, PCR results for caspase-3 and caspase-9 and Bax genes showed downregulation in MLEN treated groups. Therefore, Azadirachta indica can be considered a potential candidate for protection of nephrotoxicity induced by cisplatin.

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“…A study was performed to investigate the neuroprotective effects of Azadirachta indica leaves against cisplatin- (CP-) induced neurotoxicity and results showed that morphological findings of neem before and after CP injection implied a well-preserved brain tissue. No changes, in biochemical parameters, were observed with neem treated groups [ 97 ].…”

Section: Neuroprotective Effectsmentioning

confidence: 99%

Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment

Alzohairy

2016

Evidence-Based Complementary and Alternative Medicine

532

308

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Neem (Azadirachta indica) is a member of the Meliaceae family and its role as health-promoting effect is attributed because it is rich source of antioxidant. It has been widely used in Chinese, Ayurvedic, and Unani medicines worldwide especially in Indian Subcontinent in the treatment and prevention of various diseases. Earlier finding confirmed that neem and its constituents play role in the scavenging of free radical generation and prevention of disease pathogenesis. The studies based on animal model established that neem and its chief constituents play pivotal role in anticancer management through the modulation of various molecular pathways including p53, pTEN, NF-κB, PI3K/Akt, Bcl-2, and VEGF. It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect. In this review, I summarize the role of Azadirachta indica in the prevention and treatment of diseases via the regulation of various biological and physiological pathways.

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Azadirachta indica attenuates cisplatin-induced neurotoxicity in rats

Cited by 42 publications

References 24 publications

Pomegranate (Punica granatum) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Stress in Female BALB/c Mice

Pomegranate (Punica granatum) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Stress in Female BALB/c Mice

Azadirachta indicaAttenuates Cisplatin-Induced Nephrotoxicity and Oxidative Stress

Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment

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