First report of 16S rRNA methylase ArmA-producing Acinetobacter baumannii and rapid spread of metallo-β-lactamase NDM-1 in Algerian hospitals

Bakour, Sofiane; Touati, Abdelaziz; Bachiri, Taous; Sahli, Farida; Tiouit, D.; Naim, M.; Azouaou, Mounia; Rolain, Jean‐Marc

doi:10.1016/j.jiac.2014.07.010

Cited by 46 publications

(29 citation statements)

References 22 publications

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“…NDM-1 was previously reported by other authors in Western Algeria [31] and just recently in Eastern Algeria and in a hospital in Algiers [39]. This MBL detected originally in enterobacteria was later described in Acinetobacter, with a link with the Indian subcontinent and in some cases with the Balkan region and the Middle East [6] .…”

Section: Discussionsupporting

confidence: 63%

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High prevalence of multidrug-resistance in Acinetobacter baumannii and dissemination of carbapenemase-encoding genes blaOXA-23-like, blaOXA-24-like and blaNDM-1 in Algiers hospitals

Khorsi

Messai

Hamidi³

et al. 2015

Asian Pacific Journal of Tropical Medicine

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Section: Discussionsupporting

confidence: 63%

“…OXA-24-like is also a widely disseminated cluster, however at a lesser prevalence than OXA-23-like [5]. In Algeria, Oxa-23-like and OXA-24-like were previously reported in Eastern and Western Algeria [31,35,38] and just recently in a hospital in Algiers [39].…”

Section: Discussionmentioning

confidence: 85%

High prevalence of multidrug-resistance in Acinetobacter baumannii and dissemination of carbapenemase-encoding genes blaOXA-23-like, blaOXA-24-like and blaNDM-1 in Algiers hospitals

Khorsi

Messai

Hamidi³

et al. 2015

Asian Pacific Journal of Tropical Medicine

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“…Indeed, NDM-1 was first reported in India from Enterobacteriaceae and then in A. baumannii [126,127]. Other reports are from different European countries and from China, Japan, Kenya, Brazil, Algeria and Syria [128][129][130][131][132][133][134][135][136][137]. An outbreak of NDM-1-producing A. baumannii, belonging to ST85, was recently reported in France [138], underscoring the growing concern related to the spread of these isolates in Europe.…”

Section: Acinetobacter Baumanniimentioning

confidence: 99%

“…Such isolates have been identified in China [274], South Korea [275,276], Vietnam [277], Japan [278], North America [279], Norway [280], Italy [281], Bulgaria [282], Iran [283] and Algeria [136]. The armA gene was always found to be located on a functional composite transposon Tn1548 [279].…”

Section: Acinetobacter Baumanniimentioning

confidence: 99%

Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii : Mechanisms and epidemiology

Potron

Poirel

Nordmann

2015

International Journal of Antimicrobial Agents

573

460

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Multidrug resistance is quite common among non-fermenting Gram-negative rods, in particular among clinically relevant species including Pseudomonas aeruginosa and Acinetobacter baumannii. These bacterial species, which are mainly nosocomial pathogens, possess a diversity of resistance mechanisms that may lead to multidrug or even pandrug resistance. Extended-spectrum ␤-lactamases (ESBLs) conferring resistance to broad-spectrum cephalosporins, carbapenemases conferring resistance to carbapenems, and 16S rRNA methylases conferring resistance to all clinically relevant aminoglycosides are the most important causes of concern. Concomitant resistance to fluoroquinolones, polymyxins (colistin) and tigecycline may lead to pandrug resistance. The most important mechanisms of resistance in P. aeruginosa and A. baumannii and their most recent dissemination worldwide are detailed here.

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“…Enhancement of the inhibition zone between the disks containing clavulanic acid and cefotaxime, ceftazidime, or aztreonam indicated the presence of ESBL production [14]. Imipenem-resistant isolates were screened for carbapenemase production using the modified Hodge test (MHT), the modified Carba NP test (MCNP) and the EDTA test as previously described [15][16][17][18].…”

Section: Phenotypic Detection Of Esbls and Carbapenemasesmentioning

confidence: 99%

Carbapenemases and extended-spectrum β-lactamases producing Enterobacteriaceae isolated from Tunisian and Libyan hospitals

Mathlouthi

Al-Bayssari

Salabi

et al. 2016

J Infect Dev Ctries

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Introduction: The aim of the study was to investigate the prevalence of extended-spectrum β-lactamase (ESBL) and carbapenemase production among clinical isolates of Enterobacteriaceae recovered from Tunisian and Libyan hospitals. Methodology: Bacterial isolates were recovered from patients in intensive care units and identified by biochemical tests and MALDI-TOF. Antibiotic susceptibility testing was performed by disk diffusion and the E-test method. ESBL and carbapenemase activities were detected using standard microbiological tests. Antibiotic resistance-encoding genes were screened by PCR and sequencing. Clonal relationships between Klebsiella pneumoniae strains were carried out using multi-locus sequence typing (MLST). Results: A total of 87 isolates were characterized, with 51 and 36, respectively, identified as E. coli and K. pneumoniae. Overall the resistance prevalence was high for aminoglycosides (> 60%), fluoroquinolones (> 80%), and extended-spectrum cephalosporins (> 94%), and was low for imipenem (11.4%). Among this collection, 58 strains (66.6%) were ESBL producers and 10 K. pneumoniae strains (11.4%) were carbapenemase producers. The antibiotic resistance-encoding genes detected were blaCTX-M-15 (51.7%), blaTEM-1 (35.6%), several variants of blaSHV (21.8%), and blaOXA-48 (11.4%). The MLST typing of K. pneumoniae isolates revealed the presence of multiple clones and three novel sequence types. Also, close relationships between the OXA-48-producing strains from Tunisia and Libya were demonstrated. Conclusions: This study is the first paper describing the emergence of carbapenemase-and ESBL-producing Enterobacteriaceae, sensitive to colistin, isolated in Tunisia and Libya. Active surveillance and testing for susceptibility to colistin should be implementing because resistance to colistin, mainly in Klebsiella, has been recently reported worldwide.

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First report of 16S rRNA methylase ArmA-producing Acinetobacter baumannii and rapid spread of metallo-β-lactamase NDM-1 in Algerian hospitals

Cited by 46 publications

References 22 publications

High prevalence of multidrug-resistance in Acinetobacter baumannii and dissemination of carbapenemase-encoding genes blaOXA-23-like, blaOXA-24-like and blaNDM-1 in Algiers hospitals

High prevalence of multidrug-resistance in Acinetobacter baumannii and dissemination of carbapenemase-encoding genes blaOXA-23-like, blaOXA-24-like and blaNDM-1 in Algiers hospitals

Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii : Mechanisms and epidemiology

Carbapenemases and extended-spectrum β-lactamases producing Enterobacteriaceae isolated from Tunisian and Libyan hospitals

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