High prevalence of multidrug-resistance in Acinetobacter baumannii and dissemination of carbapenemase-encoding genes blaOXA-23-like, blaOXA-24-like and blaNDM-1 in Algiers hospitals

Khorsi, Khadidja; Messai, Yamina; Hamidi, Moufida; Ammari, Houria; Bakour, Rabah

doi:10.1016/j.apjtm.2015.05.011

Cited by 65 publications

(35 citation statements)

References 55 publications

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“…Previous studies have reported similar results (Jeannot et al, 2014;Santimaleeworagun et al, 2014;Khorsi et al, 2015;Mathlouthi et al, 2015;Memish et al, 2015;Wang et al, 2015). Khorsi et al (2015) analyzed the prevalence of A. baumannii multidrugresistance in hospitals in Algiers, and found that carbapenem resistance was mainly mediated by blaOXA-23 and blaOXA-24 genes. Wang et al (2015) also identified the blaOXA-23 gene in multidrug-resistant A. baumannii isolates from Libyan hospitals.…”

Section: Discussionsupporting

confidence: 64%

Molecular characterization of carbapenemase genes in Acinetobacter baumannii in China

Fang¹,

Wang²,

Dang³

et al. 2016

Genet. Mol. Res.

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ABSTRACT.Acinetobacter baumannii is an aerobic non-motile Gramnegative coccobacillus, and it is one of the most important nosocomial pathogens worldwide. The aim of this study was to determine the molecular epidemiology of the outbreak strains. Between March 2011 and March 2014, a total of 205 strains of A. baumannii were isolated from patients at the Nanyang City Center Hospital. The blaOXA-23, blaOXA-24, blaOXA-51, and blaOXA-58 genes were amplified by multiplex polymerase chain reaction. We found that 68 (33.17%) strains were positive for the blaOXA-23 gene, and 88.24% of these 68 showed resistance to carbapenems, while 11.76% were sensitive to carbapenems. The blaOXA-51 gene was found in 132 (64.39%) strains, and 17.42% of these were resistant to carbapenems while 82.58% were sensitive to carbapenems. Moreover, 5 (2.44%) strains were positive for blaOXA-58, of which 80% were resistant to carbapenems and 20% were sensitive to carbapenems. We found that A. baumannii showed 100% drug resistance to ampicillin, cefotetan, cefazolin, and cefoperazone. Our findings suggest that the blaOXA-23 and blaOXA-51 genes are most frequently identified in A. baumannii, while blaOXA-23 is the most important gene for resistance to carbapenems.

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Section: Discussionsupporting

confidence: 64%

Molecular characterization of carbapenemase genes in Acinetobacter baumannii in China

Fang¹,

Wang²,

Dang³

et al. 2016

Genet. Mol. Res.

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“…In this study, 41.7% of gram-negative bacteria, including A. baumannii, were MDR strains and 60% were positive simultaneously for metalo beta lactamase and AmpC production. Mahdian from Tehran and Khadidja from Aljazira reported that 70.3% and 93.6% of isolated A. baumannii from clinical specimens were found to be MDR strains (24,25).…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Detection of Β-Lactam Antibiotics, Methicillin and Inducible Clindamycin Resistance Among Bacterial Isolates in Patients with Otitis Externa

et al. 2018

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“…These proteins are of low frequency, and most of the studies have been conducted on the bacteria of the Enterobacteriaceae family. Studies performed to identify the qnr genes in A. baumannii isolates have not been so successful (15). Another important mechanism in the creation of quinolones resistance is mutation in quinolone resistance-determining regions (QRDR), where the target enzymes of DNA gyrase (gyrA) and Topoisomerase IV (parC) are affected.…”

Section: Introductionmentioning

confidence: 99%

Determination of Different Fluoroquinolone Mechanisms Among Clinical Isolates of Acinetobacter baumannii in Tehran, Iran

Khayat

Sadeghifard

Pakzad

et al. 2017

Iran Red Crescent Med J

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Background: Acinetobacter baumannii isolates resistant to fluoroquinolones, such as levofloxacin and ciprofloxacin are being increasingly developed every day. Objectives: In this study, ciprofloxacin resistance in A. baumannii isolates was determined by the presence or absence of efflux pump inhibitors, as the efflux pumps play an important role in the creation of ciprofloxacin resistance. Methods: One hundred and three Acinetobacter isolates were collected from ventilator-associated pneumonia (VAP) and burn patients of Tehran hospitals, Iran, during six months of 2014. Susceptibility rates of the isolates to levofloxacin and ciprofloxacin antibiotics were assessed using the agar disk diffusion and broth microdilution. The effects of the efflux pump inhibitors including

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High prevalence of multidrug-resistance in Acinetobacter baumannii and dissemination of carbapenemase-encoding genes blaOXA-23-like, blaOXA-24-like and blaNDM-1 in Algiers hospitals

Abstract: This study highlighted the high prevalence of imipenem resistance in Acinetobacter baumannii in Algiers hospitals mediated mainly by blaOXA-23-like, blaOXA-24-like, and blaNDM-1 genes.

Cited by 65 publications

References 55 publications

Molecular characterization of carbapenemase genes in Acinetobacter baumannii in China

Molecular characterization of carbapenemase genes in Acinetobacter baumannii in China

Phenotypic Detection of Β-Lactam Antibiotics, Methicillin and Inducible Clindamycin Resistance Among Bacterial Isolates in Patients with Otitis Externa

Determination of Different Fluoroquinolone Mechanisms Among Clinical Isolates of Acinetobacter baumannii in Tehran, Iran

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