Findings on lipid peroxidation and antioxidant function in hypertensive complications of pregnancy

Abstract

Objective To assess lipid peroxidation and antioxidant function in hypertensive complications of pregnancy. Design Cross sectional study comparing pre‐eclamptic and control patients. Setting Tampere University Hospital, Finland. Subjects Twenty healthy women with normal, uncomplicated pregnancy; 23 women with severe pre‐eclampsia; 20 women with mild pre‐eclampsia; and 13 women with pregnancy‐induced hypertension. Main outcome measures Conjugated dienes; tiobarbituric acid—reactive material or malondialdehyde (MDA); fluorescent chromolipids (FCL); glutathione peroxidase (GSHPx); selenium; uric acid; and vitamin E. Results Lipid peroxidation assessed by the appearance of conjugated dienes and malondialdehyde was significantly increased in the hypertensive patients as compared with control patients. Lipid peroxidation products also showed high correlation to the level of blood pressure, but failed to show significant relation to the outcome of the fetus. The activities of erythrocyte and plasma glutathione preoxidase were increased in severe pre‐eclampsia, and high levels of plasma or platelet glutathione peroxidase were found to have some association with fetal growth retardation or asphyxia. Conclusions Our findings give support to those few studies considering lipid peroxidation as an important factor in the pathogenesis of pre‐eclampsia. The rise in antioxidants is probably of compensatory nature responding to the increased peroxide load in pre‐eclampsia and may reflect the severity of the disease.

Antioxidant Status and Urinary Stone Risk Parameters in Essential Hypertension.

“…Similar changes have been reported in plasma [15] and neutrophils in hypertensive patients [25]. Though no change in the plasma ascorbic acid level was observed, the reduction in GSH and SOD in the hemolysate suggests that the red blood cell antioxidant system is altered, which disorder may eventually affect membrane functions.…”

“…The induction of lipid peroxidation is considered to be important in the etiology of many pathogenic diseases [13,14]. An elevated level lipid peroxides is reported in hypertensives [15] and in renal stone formation [16]. In the present study, we investigated the role of antioxidants and urinary stone risk parameters in hypertensive patients.…”

Serum lipids and malondialdehyde levels in primiparous patients with pregnancy induced hypertension

“…There was no fetal deaths or anamolies in the neonates born. The diagnosis of PIH was done as per the norms of American college of Obstetrics and Gynaecologists (4). The definition includes.…”

“…Serum lipids increase significantly during pregnancy and are further elevated two fold during PIH (4,5,6). Several studies have shown that lipid peroxides like malondialdehyde (MDA) are significantly elevated in mild and severe PIH (7,8,9).…”

The Study of β HCG Level Along With General Biochemical Profile in Pre-eclampsia

“…Pregnancy is associated with physiological hyperlipidemia but in PIH they increase two fold (5,6). Abnormal lipoproteins levels are responsible for damage to endothelium that leads to high blood pressure, and proteinuria; these are important signs of PIH (7).…”