The Study of β HCG Level Along With General Biochemical Profile in Pre-eclampsia

Yadav, Sumitra; Shrivastava, Namrata; Paneri, Sangita; Pawar, Preeti

doi:10.9790/0853-13742831

Cited by 4 publications

(8 citation statements)

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“…The median hCG level in normotensive pregnancies was higher than the pregnancies with PIH, however, the difference was not statistically significant. This finding is in contrast to previous studies which mostly report higher hCG in hypertensive pregnancy or pre-eclampsia compared to normotensive pregnancies (Dubey et al 2013;Yadav et al 2014).…”

Section: Discussioncontrasting

confidence: 99%

Early Second Trimester hCG of Maternal Serum as Predictor Marker for Pregnancy Induced Hypertension

Mansor¹

2018

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Masalah hipertensi akibat kehamilan (PIH) adalah antara punca utama penyakit hipertensi di kalangan wanita hamil. Ia juga merupakan penyebab utama bagi morbiditi dan mortaliti terhadap ibu dan anak. Pertumbuhan serta perkembangan uri yang tidak normal di dalam PIH menyebabkan peningkatan paras hormon hCG di trimester kedua. Jesteru itu, hormon hCG mempunyai peranan di dalam ramalan kejadian PIH. Objektif kajian ini adalah untuk menilai keupayaan hormon hCG di trimester kedua dalam meramal kejadian PIH serta impak obstetrik. Kajian kohort ini melibatkan pengambilan darah bagi analisa paras hormon hCG bagi 34 orang wanita hamil di antara tempoh kehamilan 14-20 minggu. Analisa paras hormone hCG adalah melalui kaedah 'chemiluminescent immunoassay'. Tiga orang wanita hamil (8.8%) menghidapi PIH manakala selebihnya adalah normal. Fungsi hormon hCG di trimester kedua dalam meramal PIH adalah rendah (AUC = 0.398). 'Multiple of median' (MoM) digunakan untuk meningkatkan keupayaan hormon hCG dengan nilai MoM melebihi 2 dianggap sebagai tahap hCG tinggi. Semua kehamilan dengan PIH mempunyai nilai <2 MoM. Bagi kehamilan normal, 29 (93.5%) mempunyai nilai <2 MoM dan 2 (6.5%) dengan nilai >2 MoM (p>0.655). Tiada hubungan yang signifikan antara tahap hormon hCG dengan impak kehamilan akibat PIH. Kesimpulannya, nilai hormon hCG pada trimester kedua sebagai penanda ramalan untuk PIH adalah rendah. Limitasi kajian adalah disebabkan kekurangan jumlah kes hipertensi. Kata kunci: darah tinggi, human chorionic gonadotrophin, kehamilan Human chorionic gonadotrophin (hCG) hormone is a sialylated glycoprotein with a mass of 37 kDa, which is secreted by

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Section: Discussioncontrasting

confidence: 99%

Early Second Trimester hCG of Maternal Serum as Predictor Marker for Pregnancy Induced Hypertension

Mansor¹

2018

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“…12 Similarly, in the study conducted by Yadav S et al, mean systolic blood pressure in normotensive group was 120.8±2.74 mmHg and in PIH group was 153.2±16.14 mmHg and difference were significant with p value <0.001. 13 In our study mean diastolic blood pressure in normotensive group was 74.76±5.23 mmHg and in PIH group was 97±6.7 mmHg and difference were significant with p value <0.001. And the above findings were profoundly supported by the other studies conducted in the similar prospect.…”

Section: Resultssupporting

confidence: 44%

“…12 In the study conducted by Yadav S et al, mean Diastolic blood pressure in Normotensive group was 74.32±2.21 mmHg and in PIH group was 103.0±10.351 mmHg and difference was significant with p value <0.001. 13 There was a marked rise in the total cholesterol levels of patients with preeclampsia in our study in comparison to the control group. The total cholesterol in normotensive group was 245.47±20.07 mg/dl and in PIH group was 278.5±52.52 mg/dl and difference were significant statistically with p value <0.0005.…”

Section: Resultssupporting

confidence: 43%

“…12 In the study conducted by Yadav S et al, total cholesterol in normotensive group was 143.33±25.24 mg/dl and in PIH group was 242.38±52.03 mg/dl and difference were statistically significant with p value <0.001. 13 In the study conducted by Shahu S et al, Total cholesterol in normotensive group was 172.1±9.3 mg/dl and in PIH group was 293.3±15.7 mg/dl and difference were statistically significant with p value <0.001. 14 There was significant rise in the triglycerides levels in pre-eclampsia as compared to normal pregnancy in our study, which was similar to other reports.…”

Section: Resultsmentioning

confidence: 88%

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Estimation and comparison of serum lipid profile of women with pregnancy induced hypertension and normal pregnancy

Dev

Sood

Sharma

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertensive disorders during pregnancy are the most common medical complication seen during pregnancy, affecting around 5-10% of all pregnancies. Raised blood pressure in pregnancy is the major cause of fetomaternal morbidity and mortality. The most important feature in preeclampsia is hypertension which is supposed to be due to vasospastic phenomenon in kidney, uterus, placenta and brain. Altered lipid synthesis leading to decrease in PGI2:TXA2 ratio is also supposed to be an important way of pathogenesis in pregnancy induced hypertension.Methods: This one-year prospective case control study total 200 pregnant women attending antenatal care and admitted in eclampsia ward fulfiling the inclusion criteria were studied. Serum lipid profile was estimated by semiautomatic analyzers. Statistical analysis of data was done by student’s t-test and p-value.Results: Mean total cholesterol in pregnancy induced hypertension was 278.5±52.52 mg/dl and normal pregnancy was 245.47±20.075 mg/dl. Mean triglycerides in pregnancy induced hypertension was 249.88±92.575 mg/dl and normal pregnancy was 206.89±46.345 mg/dl. Mean HDL in pregnancy induced hypertension was 43.69±4.135 mg/dl and normal pregnancy was 49.9±6.501 mg/dl. Mean LDL in pregnancy induced hypertension was 174.43±39.083 mg/ dl and normal pregnancy was 151.22±19.92 mg/dl. Mean VLDL in pregnancy induced hypertension was 46.885±15.143 mg/dl and in normal pregnancy was 40.964±9.061 mg/dl, total cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides were increased in pregnancy induced hypertension when compared to normal pregnancy, which is statistically significant.Conclusions: We concluded that the Patient who developed pre-eclampsia have abnormal lipid profile. This abnormal lipid profile is responsible for endothelial dysfunction. This endothelial dysfunction may play a key role the pathophysiology of pre-eclampsia. Early detection of these parameters may help patient by preventing complications and is going to aid in better management of pre-eclampsia.

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“…13 The free β-subunit can derive from three sources, namely, direct trophoblast cell production, dissociation of hCG into free α-and free β-subunits, and by macrophage or neutrophil enzymes nicking the hCG molecule. [14][15][16] The free β-hCG circulating in maternal serum corresponds to only about 0.3-4% of the total hCG. 17,18 During pregnancy, free beta hCG level can be first detected by a blood test at about 11 days after conception.…”

Section: Introductionmentioning

confidence: 99%

Association of serum nitric oxide, free beta human chorionic gonadotropin and body mass index in first trimester pregnancy

Kumar

Ghoshal

Razab

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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The Study of β HCG Level Along With General Biochemical Profile in Pre-eclampsia

Abstract: Abstract:Objective-Preeclampsia is one of the leading cause of maternal mortality and morbidity worldwide.

Cited by 4 publications

References 10 publications

Early Second Trimester hCG of Maternal Serum as Predictor Marker for Pregnancy Induced Hypertension

Early Second Trimester hCG of Maternal Serum as Predictor Marker for Pregnancy Induced Hypertension

Estimation and comparison of serum lipid profile of women with pregnancy induced hypertension and normal pregnancy

Association of serum nitric oxide, free beta human chorionic gonadotropin and body mass index in first trimester pregnancy

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