Serum lipids and malondialdehyde levels in primiparous patients with pregnancy induced hypertension

Mohanty, Sujata; Nayak, N.; Nanda, Nivedita; Rao, Pragna

doi:10.1007/bf02913094

Cited by 18 publications

(12 citation statements)

References 14 publications

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“…Endothelial dysfunction is the most important event in the pathogenesis of hypertension during pregnancy and abnormal levels of lipid profile play their critical role in the induction of endothelial dysfunction. [11][12][13] In our study the mean serum triglyceride levels were higher in the study group than the control group, similar findings were also seen in the studies done by Commaracammy A et al, Torum Clausen et al, Ware Jauregui S et al, and Mohanty S et al [14][15][16][17] This changes seen in the preeclmaptic patients is due to increased hepatic lipase activity and decrease in lipoprotein lipase activity and also there will be delay in the uptake of triglyceride to the liver among the pre eclamaptic pregnancies.…”

Section: Discussionsupporting

confidence: 90%

A comparative analysis of serum lipid profile between normotensive and hypertensive pregnant women

Sridhara

2019

Int J Reprod Contracept Obstet Gynecol

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Background: The pregnancy results in the development of the placenta which is characterized by the hormonal changes in the women body, which results in the alteration of lipid profile, diabetic state of the pregnant mothers and many others. Objective of this study was to compare the of serum lipid profile between normotensive and hypertensive pregnant women.Methods: A hospital based cross sectional study was conducted by the department of OBG, Hassan Institute of Medical Sciences, Hassan from July 2018 to December 2018. A total of 6 months the study was conducted. A total of 50 pregnant mothers who were more than 20 weeks of gestation and suffering from Preeclampsia were include in the study group and 50 Pregnant mothers who were more than 20 weeks of gestation and normotensive were included in the controls.Results: Majority of the study subjects in both the groups were less than 25 years of age. The mean age of mothers in study group was 23.19 years and 24.19 years in the control group. The mean HDL level was more among the normotensive group than the pre eclamptic group and the p value was found to be statistically insignificant. The VLDL, LDL and triglyceride level was more in the pre eclamptic group than the normotensive group and the association was also found to be statistically significant.Conclusions: Hormonal changes in pregnancy results in physiological Hyperlipidemia, in conditions like pre-eclampsia triglyceride are elevated more than the normal rise seen in normal pregnancy. Increased lipid profile with raised TG, VLDL, LDL levels leads to the development of Preeclampsia by increasing the oxidative stress and the endothelial dysfunction.

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Section: Discussionsupporting

confidence: 90%

A comparative analysis of serum lipid profile between normotensive and hypertensive pregnant women

Sridhara

2019

Int J Reprod Contracept Obstet Gynecol

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“…In the present study, TC was significantly increased (p <0.01) in PIH subjects compared to control subjects consistent with other studies. [20][21][22][23][24][25][26][27] But no significant changes in TC could be observed by some other workers. 5,19,24,28,29 Finnish and Peruvian PIH subjects had higher mean TG and lower HDL-C than the control group.…”

Section: Discussionmentioning

confidence: 99%

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Saxena¹,

Thimmaraju²,

Srivastava³

et al. 2015

J Clin Sci Res

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Background: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MDA) in pregnancy may be helpful in predicting the development of PIH and further progression. Material and methods:In this prospective case-control study, serum lipid profile and MDA were estimated in 70 PIH subjects with gestational hypertension, pre-eclampsia, eclampsia; and 70 normotensive pregnant women aged 18 -40 years, with gestational age of over 20 weeks.Results: A statistically significant higher serum total cholesterol, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), TC/HDL-C, LDL-C/HDL-C and MDA, and a significantly lower HDL-C was noted in PIH subjects as compared to control subjects. When compared with the severity of PIH, all the lipoproteins (except HDL-C) along with MDA were found to be higher in women with eclampsia when compared with gestational hypertension, pre-eclampsia and normotensive pregnant women. Conclusions:An abnormal lipid metabolism along with oxidative stress may add to the promotion of vascular dysfunction leading to PIH. Lipoproteins and MDA alter significantly in eclampsia. Therefore, during pregnancy, early diagnosis and management of dyslipidaemia may prevent lipid peroxidation and progression of PIH thereby preventing obstetric complications.

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“…An imbalance between pro -oxidants and anti -oxidants results in oxidative stress which increases the potential for the development of pre eclampsia [12]. There is raised serum iron, percent transferrin saturation, serum ferritin and decreased TIBC, UIBC and serum transferrin and ceruloplasmin levels in preeclamptic women compared to the normal healthy pregnant controls.…”

Section: Preeclampsia and Iron Levelsmentioning

confidence: 99%

Pre Eclampsia and Iron Status: A Review

Kandi¹,

Sudhakar²,

Ramadevi³

et al. 2014

AJMBR

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Preeclampsia is an idiopathic multisystem disorder specific to pregnancy and development of hypertension and proteinuria, increased vascular resistance and endothelial dysfunction in the mother , altered placental perfusion and restricted fetal growth. The vasospasm leads to destruction of RBCs release iron thus, there is elevated serum iron levels in preeclamptic women. The excess iron released from destruction of RBCs can react with free radicals produced from cell membrane (as it is rich in polyunsaturated fatty acids) and circulating lipoproteins initiates lipid peroxidation both in placenta and vasculature. This is one of the significant etiologic factors in the endothelial cell damage of preeclampsia. the raised serum iron levels in turn alters the iron related parameters like total iron binding capacity(TIBC), serum ferritin, transferrin, percent saturation.

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Serum lipids and malondialdehyde levels in primiparous patients with pregnancy induced hypertension

Cited by 18 publications

References 14 publications

A comparative analysis of serum lipid profile between normotensive and hypertensive pregnant women

A comparative analysis of serum lipid profile between normotensive and hypertensive pregnant women

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Pre Eclampsia and Iron Status: A Review

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