Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Abstract

Background: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MDA) in pregnancy may be helpful in predicting the development of PIH and further progression. Material and methods:In this prospective case-control study, serum lipid profile and MDA were estimated in 70 PIH subjects with gestational hypertension, pre-eclampsia, eclampsia; and 70 normotensive pregnant women aged 18 -40 years, with gestational age of over 20 weeks.Results: A statistically significant higher serum total cholesterol, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), TC/HDL-C, LDL-C/HDL-C and MDA, and a significantly lower HDL-C was noted in PIH subjects as compared to control subjects. When compared with the severity of PIH, all the lipoproteins (except HDL-C) along with MDA were found to be higher in women with eclampsia when compared with gestational hypertension, pre-eclampsia and normotensive pregnant women. Conclusions:An abnormal lipid metabolism along with oxidative stress may add to the promotion of vascular dysfunction leading to PIH. Lipoproteins and MDA alter significantly in eclampsia. Therefore, during pregnancy, early diagnosis and management of dyslipidaemia may prevent lipid peroxidation and progression of PIH thereby preventing obstetric complications.

Placental endothelial nitric oxide synthase expression and role of oxidative stress in susceptibility to preeclampsia in Pakistani women

“…Many studies determined contradictory results of elevated ROS and TBARS but reduced antioxidants in PE (Cohen et al, 2015;Mutlu-Türko et al, 1998). Increased TBARS levels showed the increase lipid peroxidation in cells and may suggest decreased enzymatic free radical scavenging capacity in preeclamptic patients (Biri et al, 2007;Gupta et al, 2009;Saxena et al, 2015).…”

Feto-maternal impact of altered lipid profile in pregnancy

“…[6][7][8][9][10][11] Jin WY et al, Saha D et al, Saxena S et al, Vidyabati RK, Islam NAF and Aziz R they all agree on the fact that dyslipidemia was significantly associated with pre eclampdia and eclampsia. [6][7][8][9][10][11] As hypertensive disorder developed, there was development of fetal complications. The women with severe dyslipidemia developed fetal complication of severe IUGR and IUD in their late second and early third trimester with very poor outcome.…”

Rasio Low Density Lipoprotein dan High Density Lipoprotein pada Preeklamsi Berat dibandingkan dengan Kehamilan Normal di Rumah Sakit Dr. Hasan Sadikin Bandung

“…Oxidized LDL will be phagocytized by macrophage forming foam cells and increasing accumulation of monocytes which will stimulate cytokines production and cause endothelial damage. 5,6,7,8 Increase of small LDL will cause the risk of endothelial damage due to its nature of being easily oxidized which will trigger inflammatory reaction on endothelium. The decrease of HDL will aggravate the reaction due to the decrease of free cholesterol transported back to liver.…”

“…Endothelial dysfunction will cause imbalance production between vasodilator and vasoconstrictor which will cause massive vasoconstriction and therefore preeclampsia syndrome. 6,9,10,11,12 The current study was to compare the values of LDL level, HDL level, and LDL/HDL ratio in women with severe preeclampsia and normal pregnancy.…”