Ferroptosis-Related Long Noncoding RNAs as Prognostic Marker for Colon Adenocarcinoma

Qiu, Yuting; Li, Haobo; Zhang, Qian; Qiao, Xinwei; Wu, Jing

doi:10.1155/2022/5220368

Cited by 41 publications

(37 citation statements)

References 48 publications

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“…Combined with our results, the lncRNA FOXD3-AS1 con rmed overexpressed in glioma, colon cancer and lung cancer [17][18][19][20]. Besides, a series study that ferroptosis and autophagy related lncRNA model constructed risk signature for CC prognosis containing EIF3J-DT [21,22]. Meanwhile, a study suggests MIR210HG were associated with survival and metastasis in CC [23].…”

Section: Disscussionsupporting

confidence: 66%

Succinylation-Associated LncRNA Signature as the Prognosis of Colon Cancer Identified by an Integrative Bioinformatics Analysis

Zhang

Shen

et al. 2022

Preprint

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Though treatment techniques and strategies for colon cancer (CC) enhanced, the 5-year survival rate has not been significantly improved. Succinylation and long noncoding RNAs (lncRNAs) are uncertain for the prognostic value in the CC patients. We applied to analyze and obtain succinylation-related lncRNA by coexpression in CC. A novel succinylation-related lncRNA model was constructed by univariate and lasso regression analysis and established principal component analysis (PCA), functional enrichment annotation, tumor immune environment, drug sensitivity and nomogram to verify the model, respectively. Six succinylation-related lncRNA in CC were finally confirmed and distinguish the survival status in our model which was statistically significant differ in training set, testing set, and entire set. The prognosis value with this model associated with age, gender, M0 stage, N2 stage, T3+T4 stage and Stage III+IV. The high-risk group showed a higher mutation rate than the low-risk group. We constructed a model predict overall survival for 1-, 3-, and 5-year with AUCs of 0.694, 0.729, and 0.802. Cisplatin and Temozolomide compounds possess sensitivity in the high-risk group. Our study provided novel insights into the value of the succinylation related lncRNA signature as a predictor of prognosis, which possess high clinical application value in the future.

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Section: Disscussionsupporting

confidence: 66%

Succinylation-Associated LncRNA Signature as the Prognosis of Colon Cancer Identified by an Integrative Bioinformatics Analysis

Zhang

Shen

et al. 2022

Preprint

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“…Moreover, a novel Six2-related gene risk model was constructed to predict the OS of KIRC patients in training and testing sessions. As cancer immunotherapy successfully treats multiple neoplasms by activating the immune response, we also tested the potential sensitivity of patients to immunotherapy and found out that the risk score model may be an available predictor of immunotherapy [29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

The Transcriptional and Immunological Roles of Six2 in Clear Cell Renal Cell Carcinoma

Tian¹,

Shi²,

Lei³

et al. 2022

Oncologie

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Background: Six2, a transcription factor, exerts an oncogenic role in clear cell renal cell carcinoma (ccRCC). Increased Six2 expression could enhance cancer metastasis. However, the regulatory mechanism of Six2 in promoting metastasis remains unclear. The purpose of this study is to analyze the regulatory pattern of Six2 and the potential role of Six2 in the tumor immune microenvironment. Materials and Methods: Firstly, transcriptional data in TCGA-KIRC cohorts was used to analyze the relationship between Six2 expression and clinical information. Secondly, we detect the association between Six2 and the tumor immune microenvironment in ccRCC. Then, we analyzed Six2-related differentially expressed genes (DEGs) and constructed a prognostic model using the Lasso-Cox algorithm by integrating Six2 ChIP data and co-expressed genes. Next, we analyzed the clinical significance and immunotherapy sensitivity of this model. Results: Six2 was overexpressed in RCC cells compared with normal kidney cells and upregulated Six2 was positively linked with clinical stage, grade, T stage, M stage, and poor survival. And Six2 was correlated with the remodeling of the tumor microenvironment. Potential downstream effectors and biological functions regulated by Six2 were identified using in silico analysis. Meanwhile, a risk model based on 8 Six2 target genes was established to classify ccRCC patients into high-and-low risk groups. This risk model showed a reliable ability to forecast the overall survival of ccRCC patients and predict the susceptibility to immunotherapy. Conclusions: Our findings provide a promising prognostic indicator for ccRCC patients and help better understand the transcriptional and immunological role of Six2 in ccRCC.

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“…Bioinformatics is an emerging discipline that emerged with the launch of the Human Genome Project (HGP), which integrates mathematics, computer science, and biology to elucidate the biological significance of various types of data. Currently, bioinformatics plays a pivotal role in the development of medicine 22–25 . In the future study, we would like to explore the current topic in bioinformatics.…”

Section: Discussionmentioning

confidence: 99%

Clinical value of serum miR‐92 and miR‐122 expression level combined with pulmonary ultrasound score in the prognosis of neonatal acute respiratory distress syndrome

Hong

Bao

Wang³

2022

Clinical Laboratory Analysis

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Purpose: To explore the value of the expression of serum miR-92 and miR-122 combined with lung ultrasound score (LUS) in the prognosis of neonatal acute respiratory distress syndrome (ARDS). Patients and methods: This study involved 148 neonatal ARDS cases from January 2018 to October 2021, of which 77 children were discharged from hospital and 31 died. The children with ARDS were classified according to disease severity based on X-ray examination as mild (n = 69 cases) and severe (n = 39 cases). The expression of serum miR-92 and miR-122 was detected by real-time fluorescence quantitative PCR and the LUS score was recorded. The data were subjected to ROC curve analysis and Pearson correlation analysis. Results:The expression of serum miR-92, miR-122, and LUS score in the patients that died were significantly higher than in those who survived (p < 0.05). These indicators were also significantly higher in the severe disease group compared to the mild disease group (p < 0.05). ROC curve showed that serum miR-92 and miR-122 combined with the LUS score had the largest area under the curve (0.920, 95% CI: 0.860-0.977) for predicting death, with a sensitivity and specificity of 92.0% and 87.0%, respectively. Pearson correlation analysis showed that the expression levels of serum miR-92 and miR-122 were positively correlated with the LUS score (all p < 0.01). Conclusions:The increased expression of serum miR-92 and miR-122 is related to the severity and prognosis of children with ARDS, combined with the LUS score are of value to predict the prognosis of children with ARDS.

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Ferroptosis-Related Long Noncoding RNAs as Prognostic Marker for Colon Adenocarcinoma

Cited by 41 publications

References 48 publications

Succinylation-Associated LncRNA Signature as the Prognosis of Colon Cancer Identified by an Integrative Bioinformatics Analysis

Succinylation-Associated LncRNA Signature as the Prognosis of Colon Cancer Identified by an Integrative Bioinformatics Analysis

The Transcriptional and Immunological Roles of Six2 in Clear Cell Renal Cell Carcinoma

Clinical value of serum miR‐92 and miR‐122 expression level combined with pulmonary ultrasound score in the prognosis of neonatal acute respiratory distress syndrome

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