Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (<scp>SIONCOV</scp>) retrospective study

Finotello, Riccardo; Vasconi, Maria Elisabetta; Sabattini, Silvia; Agnoli, Chiara; Giacoboni, C.; Annoni, Maurizio; Dentini, Alfredo; Bettini, Giuliano; Guazzi, Paolo; Stefanello, D.; Bottero, Enrico; Mesto, Paola; Marinelli, Raúl A.; Feo, C. De; Marconato, Laura

doi:10.1111/vco.12325

Cited by 29 publications

(52 citation statements)

References 28 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2017, Finotello et al . 2018). Abdominal masses, intussusception, obstruction or even perforation is mostly associated with this more aggressive form of alimentary lymphoma.…”

Section: Signalment History and Clinical Signsmentioning

confidence: 99%

See 1 more Smart Citation

Feline chronic enteropathy

Marsilio

2021

J of Small Animal Practice

View full text Add to dashboard Cite

Feline chronic enteropathy is a common disorder, especially in the senior cat population, with rising incidence over the past decade. Feline chronic enteropathy is considered an umbrella term comprising different diseases including food‐responsive enteropathy, idiopathic inflammatory bowel disease and alimentary small cell lymphoma. However, differentiation between those diseases is often difficult in practice. This review will discuss the clinical approach to cats with chronic enteropathy, state‐of‐the‐art diagnostic tests and pitfalls thereof as well as current therapeutic approaches. Although, much of the etiopathogenesis is still unknown, increased research efforts in this field have brought new insights into diagnostic and therapeutic options for these cats.

show abstract

“…2017, Finotello et al . 2018). Abdominal masses, intussusception, obstruction or even perforation is mostly associated with this more aggressive form of alimentary lymphoma.…”

Section: Signalment History and Clinical Signsmentioning

confidence: 99%

“…2012, Barrs & Beatty 2012b, Finotello et al . 2018). However, it should be noted that fine‐needle aspirates are unhelpful in differentiating IBD from SCL.…”

Section: Abdominal Ultrasoundmentioning

confidence: 99%

Feline chronic enteropathy

Marsilio

2021

J of Small Animal Practice

View full text Add to dashboard Cite

show abstract

“…In cats, paraneoplastic basophilia has previously been reported with intestinal and epitheliotropic lymphoma of T-cell origin, 1 , 2 feline large granular lymphocyte lymphoma, 8 acute and chronic myelogenous leukaemia, 3 , 4 and malignant mesenchymal tumour. 5 …”

Section: Discussionmentioning

confidence: 95%

Marked paraneoplastic basophilia accompanying eosinophilia in a cat with alimentary T-cell lymphoma

Bălan

Hope

Cassidy

et al. 2017

Journal of Feline Medicine and Surgery Open Reports

View full text Add to dashboard Cite

Case summaryA 5-year-old male neutered domestic shorthair cat was referred with a history of persistent pyrexia, pica, soft faeces, inappetence, intermittent vomiting, mild-to-moderate granulocytosis and mild hypercalcaemia. No significant improvement was noted after antibiotic and corticosteroid treatment, except that the hypercalcaemia resolved. Physical examination, including thoracic auscultation, and abdominal and peripheral lymph node palpation, were unremarkable. On admission, haematology revealed moderate leukocytosis (36.8 × 109/l) with moderate-to-marked eosinophilia (21.3 × 109/l) and marked basophilia (4.04 × 109/l), the latter identified microscopically. Lymphocytes were markedly decreased (0.37 × 109/l). Blood smear examination revealed 58% eosinophils, 28% neutrophils, 11% basophils, 2% monocytes, 1% lymphocytes and marked, diffuse platelet clumping. Biochemistry abnormalities indicated mild pancreatitis, dehydration and anorexia with mildly increased pancreatic lipase, mild hypernatraemia (157 mmol/l), a moderate decrease in urea (3.1 mmol/l) and a slight decrease in phosphate (1.32 mmol/l). Ultrasound and radiographic imaging revealed enlargement of the mesenteric lymph nodes. Fine-needle aspiration, a Tru-cut biopsy and immunohistochemistry were performed. Cytological examination revealed ~65–75% lymphocytes (~80% were larger than a neutrophil), ~25–35% eosinophils and occasional basophils. Lymphocytes had single, small (<1/3 red blood cells), prominent nucleoli and increased pale, mildly vacuolated cytoplasm. On histopathology, cells were monomorphic, large, with prominent nucleoli, and mild, multifocal, staining for T-cell marker CD3. Smaller cells were strongly CD3-positive. Cells were negative for B-cell marker CD45R.Relevance and novel informationThis is the most severe case of paraneoplastic basophilia reported with feline alimentary T-cell lymphoma with accompanying eosinophilia and lymph node infiltration. Feline basophil prevalence is reported for the first time.

show abstract

“…Feline LGL lymphoma is typically located in the small intestine, abdominal lymph nodes and liver,15 16 and the most common clinical findings described are decreased appetite or anorexia, vomiting, weight loss, diarrhoea and lethargy 15 16…”

Section: Discussionmentioning

confidence: 99%

Peritoneal lymphomatosis in a dog after resection of LGL intestinal lymphoma: imaging features

Cordella

Costantino

Baldassarre

et al. 2020

Vet Record Case Reports

View full text Add to dashboard Cite

A six-year-old intact male Chihuahua dog was referred for vomiting, diarrhoea and weight loss. Ultrasonographic (US) and computed tomographic examination revealed a focal thickening in the jejunum, with no signs of gross metastatic disease. Histology and immunohistochemistry performed after surgical resection revealed a presumed large granular lymphocytic lymphoma. Treatment with chlorambucil was started, and no signs of recurrence were noticed at serial US follow-up for the following months. Six months after surgery, several lesions were seen in the ventrolateral aspect of the peritoneal cavity both on ultrasonography and CT, and cytology confirmed the suspicion of peritoneal lymphomatosis.

show abstract

Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study

Cited by 29 publications

References 28 publications

Feline chronic enteropathy

Feline chronic enteropathy

Marked paraneoplastic basophilia accompanying eosinophilia in a cat with alimentary T-cell lymphoma

Peritoneal lymphomatosis in a dog after resection of LGL intestinal lymphoma: imaging features

Contact Info

Product

Resources

About