Feline chronic enteropathy

Marsilio, Sina

doi:10.1111/jsap.13332

Cited by 26 publications

(50 citation statements)

References 76 publications

(96 reference statements)

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“…Whilst this could, in large part, be due to the larger number of cases within this biopsy group, feline EATL-2 has been shown to manifest initially in the mucosal layer for which endoscopic biopsy sampling may be better suited than full-thickness biopsy [13][14][15]. Full-thickness biopsy has been demonstrated to provide comparatively smaller samples of mucosa and a lower number of samples at each site [23]. With evidence demonstrating that ileal biopsy rarely impacted diagnosis in cases of feline EATL-2 and the possibility of reaching the proximal jejunum in small dogs with gastroduodenoscopy, this calls into question the need to use full-thickness biopsy in these cases unless a lesion has been noted at the mid jejunum [16,21].…”

Section: Discussionmentioning

confidence: 99%

“…Full-thickness biopsy samples have traditionally been considered to be of more adequate quality than endoscopic biopsy samples; however, the latter technique is less invasive, allows earlier initiation of treatment and also facilitates direct visualization of the intestinal mucosa [21]. Small intestinal lesions in cases of CIE typically occur diffusely within the intestinal mucosa, and unpublished data produced by Marsilio et al has demonstrated that the total mucosal surface procured by full-thickness biopsy is comparatively less than that obtained via endoscopic biopsy techniques [22,23]. The impact of biopsy type on histopathologic concordance is not yet known.…”

Section: Introductionmentioning

confidence: 99%

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Concordance of the Histopathologic Diagnosis of Concurrent Duodenal and Ileal Biopsy Specimens in Dogs

Caulfield¹,

Priestnall

Kathrani

2021

Animals

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Histopathologic discordance between gastrointestinal (GI) locations in canine chronic inflammatory enteropathy (CIE) has prompted recommendations to biopsy both the duodenum and ileum, while further evaluation is required for non-CIE. We aimed to determine the concordance of histopathologic diagnosis between duodenal and ileal endoscopic or full-thickness biopsy specimens for all dogs with CIE and GI neoplasia and to assess the association between histopathologic discordance between GI locations with clinicopathologic variables. Seventy-nine dogs were eligible, with endoscopic (74) or full-thickness (5) biopsy specimens. Clinicopathological data were recorded for all dogs. Concordance of histopathologic diagnosis was retrospectively assessed for concurrent duodenal and ileal biopsy specimens by a single board-certified veterinary pathologist using the modified World Small Animal Veterinary Association (WSAVA) Gastrointestinal Standardization Group guidelines. Sixty-seven dogs were diagnosed with CIE and 5 with enteric-associated T-cell lymphoma-2 (EATL-2). Concordance of histologic diagnosis between duodenal and ileal sites was similar between endoscopic (73.0%) and full-thickness (80.0%) biopsy groups. For the CIE cases, lymphoplasmacytic enteritis had the highest concordance (73.0%) and eosinophilic enteritis the least (16.7%). Of the 5 neoplastic cases, 5/5 (100%) were present at the duodenum but only 3/5 (60%) in the ileum. No clinicopathologic variables demonstrated a statistically significant association with discordance. We conclude that the level of discordance necessitates concurrent biopsy of both duodenum and ileum in all dogs with chronic GI signs. The rate of EATL-2 was lower than rates reported for cats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Concordance of the Histopathologic Diagnosis of Concurrent Duodenal and Ileal Biopsy Specimens in Dogs

Caulfield¹,

Priestnall

Kathrani

2021

Animals

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“…Feline chronic enteropathy is a common GI disorder in elderly cats, which mainly includes idiopathic inflammatory bowel disease and LGAL, and hypocobalaminemia is a common finding in both disease entities representing malabsorption. 31 The GI tract's ability to absorb chlorambucil efficiently through enteral administration may be influenced by the malabsorptive nature of either LGAL or cancerbearing cats with concurrent inflammatory bowel disease. Clinical signs in affected cats are highly variable, and severity of disease can differ greatly among cats.…”

Section: Discussionmentioning

confidence: 99%

Population pharmacokinetics identifies rapid gastrointestinal absorption and plasma clearance of oral chlorambucil administered to cats with indolent lymphoproliferative malignancies

Al‐Nadaf

Wittenburg

Skorupski

et al. 2022

ajvr

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OBJECTIVE To establish the pharmacokinetics of a single 2-mg oral dose of chlorambucil in cats with indolent lymphoproliferative malignancies. ANIMALS 24 client-owned cats. PROCEDURES Cats were assigned to 1 of 4 groups, with each group having a total of 3 sample collection time points over 12 hours after receiving a single 2-mg oral dose of chlorambucil. Each time point combined to generate 6 full patient plasma chlorambucil concentration-time curves from the 24 cats. Chlorambucil treatment was continued every other day and a single, variably timed sample collection was obtained on day 14. Population parameter estimates were obtained by nonlinear mixed-effects modeling. Covariates investigated included age, sex, baseline serum cobalamin, study location, weight, and body condition score. RESULTS Chlorambucil administered orally to cats was found to have a peak plasma concentration of approximately 170 ng/mL (SE, 31.1 ng/mL), percent coefficient of variation (%CV) of 18.4% within 15 minutes, and a terminal half-life of 1.8 hours (SE, 0.21 hour; %CV, 12.4). At the 4-hour mark, a smaller secondary peak in plasma chlorambucil was found. Day 14 samples were similar to those of the initial dose. No covariates showed a significant effect in the population model. CLINICAL RELEVANCE In these cats, chlorambucil at a 2-mg dose administered every other day undergoes rapid gastrointestinal absorption and plasma clearance with no drug accumulation between doses. These data are critical to inform future work investigating the association of chlorambucil drug exposure with adverse events and outcome of cats with lymphoproliferative diseases.

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“…We performed a separate GWAS for each of IBD and SCAL, and then chronic enteropathy, which includes cats that were not formally diagnosed but could be either IBD or SCAL. Finally, we performed a GWAS including all GI cases in an attempt to increase statistical power, and since IBD, SCAL, and chronic enteropathy can be considered a different manifestation of the same disorder ( 71 ). There is also evidence that IBD leads to SCAL ( 72 ).…”

Section: Methodsmentioning

confidence: 99%

Complex Feline Disease Mapping Using a Dense Genotyping Array

et al. 2022

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The current feline genotyping array of 63 k single nucleotide polymorphisms has proven its utility for mapping within breeds, and its use has led to the identification of variants associated with Mendelian traits in purebred cats. However, compared to single gene disorders, association studies of complex diseases, especially with the inclusion of random bred cats with relatively low linkage disequilibrium, require a denser genotyping array and an increased sample size to provide statistically significant associations. Here, we undertook a multi-breed study of 1,122 cats, most of which were admitted and phenotyped for nine common complex feline diseases at the Cornell University Hospital for Animals. Using a proprietary 340 k single nucleotide polymorphism mapping array, we identified significant genome-wide associations with hyperthyroidism, diabetes mellitus, and eosinophilic keratoconjunctivitis. These results provide genomic locations for variant discovery and candidate gene screening for these important complex feline diseases, which are relevant not only to feline health, but also to the development of disease models for comparative studies.

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Feline chronic enteropathy

Cited by 26 publications

References 76 publications

Concordance of the Histopathologic Diagnosis of Concurrent Duodenal and Ileal Biopsy Specimens in Dogs

Concordance of the Histopathologic Diagnosis of Concurrent Duodenal and Ileal Biopsy Specimens in Dogs

Population pharmacokinetics identifies rapid gastrointestinal absorption and plasma clearance of oral chlorambucil administered to cats with indolent lymphoproliferative malignancies

Complex Feline Disease Mapping Using a Dense Genotyping Array

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