Marked paraneoplastic basophilia accompanying eosinophilia in a cat with alimentary T-cell lymphoma

Bălan, Maria; Hope, Aimee; Cassidy, Joseph; McCullough, Maureen; O’Brien, Peter J.

doi:10.1177/2055116917730180

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…6 A literature review of veterinary neoplastic and paraneoplastic basophilia revealed seven feline and seven canine cases. The feline cases consisted of three alimentary lymphomas 4,5,7 (two of which were identified as T-cell tumors 5,7 ), chronic myelogenous leukemia (CML), 8 suspected acute leukemia of uncertain lineage, 9 acute myelogenous leukemia (AML) with basophilic differentiation, 10 and acute monoblastic lymphoma with chronic basophilic leukemia. 11 All of these cases, except the AML with basophilic differentiation and the acute monoblastic leukemia with chronic basophilic leukemia, had concurrent eosinophilia, generally of greater magnitude than the basophilia (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Marked paraneoplastic basophilia in a cat with alimentary T‐cell lymphoma

Strandberg,

Serpa,

Fourez

et al. 2023

Veterinary Clinical Pathol

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An 8‐year‐old, spayed female domestic shorthair cat was presented for acute weight loss, hyporexia, intermittent vomiting, and loose stools. A caudal abdominal mass and thickened intestinal loops were palpated on initial examination. An abdominal ultrasound identified a circumferential intramural jejunal mass with complete loss of wall layering, diffuse thickening of the jejunal muscularis, and jejunal and ileocecal lymphadenomegaly. Initial routine bloodwork revealed mild monocytosis and minimal lymphopenia with reactive lymphocytes. Cytologic evaluation of the jejunal mass and enlarged lymph nodes was consistent with lymphoma (intermediate cell size), and PCR for antigen receptor rearrangement revealed a clonal T‐cell receptor rearrangement consistent with T‐cell lymphoma. Chemotherapy (CHOP protocol) was initiated, but despite initial improvement of clinical signs, a repeat ultrasound examination 5 weeks after initiation of treatment revealed no improvement in the lymphadenomegaly or reduction in the size of the jejunal mass. At this visit, the cat also developed a marked basophilia (basophils 12.28 × 103/μL, RI 0.00–0.10) with low numbers of circulating atypical lymphocytes; no concurrent eosinophilia was noted. Heartworm disease, ectoparasites, and allergic diseases were evaluated for and considered unlikely. The chemotherapy protocol was changed to L‐asparaginase, followed by lomustine. The basophilia was significantly reduced 2 days after the initial dose of L‐asparaginase and remained within the reference interval for 40 days before an eventual decline in the cat's health. To the authors' knowledge, this is the first report of paraneoplastic basophilia without concurrent eosinophilia in a cat with T‐cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Marked paraneoplastic basophilia in a cat with alimentary T‐cell lymphoma

Strandberg,

Serpa,

Fourez

et al. 2023

Veterinary Clinical Pathol

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“…Intriguingly, among the nine patients with leukemia/MPNs, four were further diagnosed with T-cell lymphoid leukemia. While there are no prior reports in the veterinary literature linking lymphoid leukemia to basophilia, there have been documented cases of T-cell lymphoma in cats resulting in marked paraneoplastic basophilia [ 29 , 30 ]. We also noted the preponderance of T-cell lymphoma in the basophilia group, suggesting a link between T-cell neoplasms and paraneoplastic basophilia.…”

Section: Discussionmentioning

confidence: 99%

Hematologic Abnormalities and Diseases Associated with Moderate-to-Marked Basophilia in a Large Cohort of Dogs

Held,

Mochizuki

2023

Veterinary Sciences

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Basophilia is a rare hematologic finding in dogs. This research aimed to describe the hematologic and clinical characteristics of dogs with moderate-to-marked basophilia. CBC reports with blood smear examinations from dogs presented to the North Carolina State University Veterinary Teaching Hospital were retrospectively reviewed for basophilia (>193 cells/µL). We classified basophilia as moderate when counts were ≥500 cells/µL and marked when they reached ≥1000 cells/µL. We compared the hematologic and clinical profiles of dogs with moderate-to-marked basophilia (the basophilia group) to those without basophilia, serving as our control group. In addition, we investigated differences between dogs with marked basophilia versus those with moderate basophilia, as well as between dogs in the basophilia group with and without concurrent eosinophilia. Diseases associated with moderate-to-marked basophilia included eosinophilic lung disease (p < 0.0001), leukemia/myeloproliferative neoplasms (p = 0.004), parasitic infection (p = 0.004), mast cell tumor (p = 0.005), and inflammatory bowel disease (p = 0.02). Overall, dogs with marked basophilia had a lower frequency of inflammatory diseases (51% vs. 70%, p = 0.009) and a higher frequency of neoplastic diseases (48% vs. 26%, p = 0.003) compared to those with moderate basophilia. In the basophilia group, concurrent eosinophilia was only seen in 36% of dogs. Dogs with concurrent eosinophilia were more often diagnosed with inflammatory diseases (77% vs. 58%, p = 0.006), with fewer diagnoses of neoplasia (19% vs. 40%, p = 0.001), compared to dogs without concurrent eosinophilia. The findings of this study offer veterinary clinicians valuable guidance in determining diagnostic priorities for dogs with moderate-to-marked basophilia.

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“…In veterinary medicine, basophilia has rarely been reported. Maria Balan et al reported feline basophil prevalence for the first time in 2017, in which case the patient was diagnosed with alimentary T-cell lymphoma ( 2 ). Other reported feline basophilia cases included lymphoma and gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) ( 8 , 9 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, even though eosinophils and basophils interact with each other at sites of inflammation, basophilia accompanying eosinophilia is extremely rare in cats. Most reported cases are associated with feline alimentary T-cell lymphoma ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: Lymphocytic-plasmacytic and eosinophilic enterocolitis presented with marked eosinophilia and basophilia in a cat

Kim,

Hwang,

Jung

et al. 2023

Front. Vet. Sci.

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Inflammatory bowel disease is a common condition in cats, characterized by recurring gastrointestinal signs with histologic evidence of intestinal inflammation. A 9-month-old neutered male Sphynx cat was presented with a 5-week history of vomiting and hematochezia. Conservative patient management with a therapeutic gastrointestinal formula, antibiotics, and antiemetics resulted in a positive response to treatment, with relapse of signs when the medications were discontinued. A new finding of marked eosinophilia and basophilia was identified 3 months after the initial presentation. Colonoscopy revealed cecal erosions and a surgical biopsy with histopathology confirmed a diagnosis of lymphocytic-plasmacytic and eosinophilic enterocolitis. For this diagnosis, the patient was treated with prednisolone, tylosin, and metronidazole. Antibiotics were gradually tapered as the cat showed clinical improvement. The patient showed resolution of the gastrointestinal signs, and the numbers of eosinophils and basophils returned within the reference range 8 weeks after the treatment began. Basophilia and eosinophilia has been reported in conjunction with feline T-cell lymphoma. However, marked basophilia accompanying eosinophilia is extremely rare in cats with inflammatory bowel disease. We herein provide clinical details, including ultrasonography, endoscopy, histopathology, and disease course of feline lymphocytic-plasmacytic and eosinophilic enterocolitis with marked basophilia and eosinophilia. This case highlights the importance of considering enteritis as potential diagnoses when eosinophilia and basophilia are concurrently observed in cats.

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Marked paraneoplastic basophilia accompanying eosinophilia in a cat with alimentary T-cell lymphoma

Cited by 6 publications

References 26 publications

Marked paraneoplastic basophilia in a cat with alimentary T‐cell lymphoma

Marked paraneoplastic basophilia in a cat with alimentary T‐cell lymphoma

Hematologic Abnormalities and Diseases Associated with Moderate-to-Marked Basophilia in a Large Cohort of Dogs

Case report: Lymphocytic-plasmacytic and eosinophilic enterocolitis presented with marked eosinophilia and basophilia in a cat

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