Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Currently, it has been established that obesity in children with bronchial asthma leads to a more severe course of the disease, a worse quality of life, and a reduced response to treatment.Purpose. To study the incidence and risk factors of simple obesity in children with bronchial asthma. The aim of the study was to study the incidence and risk factors of simple obesity in children with bronchial asthma.Material and methods. The study included 484 patients aged 7 to 14 years: the main group consisted of 237 patients with atopic bronchial asthma, the comparison group consisted of 247 children without a diagnosis of bronchial asthma.Results. Patients of the main group were obese more often (18.9%) than children of the comparison group (11.3%, p=0.019). During 5 years of bronchial asthma disease, a tendency (p=0.087) was revealed to increase the SDS body mass index indicator in the dynamics of the disease (from 0.32 to 0.45) and the number of patients with III and IV degrees of obesity (from 10.5% to 42.8%, p=0.025). In children of the main group with normal SDS body mass index before the diagnosis of bronchial asthma 5 years after the onset of the disease, in 8.5% of cases there was obesity (p<0.001) and in 23.9% — excess body weight (p<0.001), in children with initial excess body weight, obesity was diagnosed in 28.6% of cases (p=0.048), and among children who were obese at the time of bronchial asthma, 26.3% had an increase in its severity (p=0.023). In patients with bronchial asthma and obesity, according to the bioimpedance analysis findings, a pronounced imbalance between energy intake and its consumption was revealed, and according to the nutrition assessment data — an unbalanced diet, a violation of the diet and a sedentary lifestyle.Conclusion. Simple obesity occurs in 18.9% of school-age children with atopic bronchial asthma, and over the course of 5 years of the disease, the number of patients with obesity increases and its severity progresses. Therefore training of patients and their parents, correction of nutrition and increasing the volume of physical activity are an important component of treatment.
Currently, it has been established that obesity in children with bronchial asthma leads to a more severe course of the disease, a worse quality of life, and a reduced response to treatment.Purpose. To study the incidence and risk factors of simple obesity in children with bronchial asthma. The aim of the study was to study the incidence and risk factors of simple obesity in children with bronchial asthma.Material and methods. The study included 484 patients aged 7 to 14 years: the main group consisted of 237 patients with atopic bronchial asthma, the comparison group consisted of 247 children without a diagnosis of bronchial asthma.Results. Patients of the main group were obese more often (18.9%) than children of the comparison group (11.3%, p=0.019). During 5 years of bronchial asthma disease, a tendency (p=0.087) was revealed to increase the SDS body mass index indicator in the dynamics of the disease (from 0.32 to 0.45) and the number of patients with III and IV degrees of obesity (from 10.5% to 42.8%, p=0.025). In children of the main group with normal SDS body mass index before the diagnosis of bronchial asthma 5 years after the onset of the disease, in 8.5% of cases there was obesity (p<0.001) and in 23.9% — excess body weight (p<0.001), in children with initial excess body weight, obesity was diagnosed in 28.6% of cases (p=0.048), and among children who were obese at the time of bronchial asthma, 26.3% had an increase in its severity (p=0.023). In patients with bronchial asthma and obesity, according to the bioimpedance analysis findings, a pronounced imbalance between energy intake and its consumption was revealed, and according to the nutrition assessment data — an unbalanced diet, a violation of the diet and a sedentary lifestyle.Conclusion. Simple obesity occurs in 18.9% of school-age children with atopic bronchial asthma, and over the course of 5 years of the disease, the number of patients with obesity increases and its severity progresses. Therefore training of patients and their parents, correction of nutrition and increasing the volume of physical activity are an important component of treatment.
The proposed review is devoted to the analysis of the main mechanisms of the formation of IgE-producing cells in the body and a brief review of the main, most striking candidate agents for use in innovative methods of therapy for IgE-dependent pathologies. Data are presented according to which the role of IgE+ plasma cells and various subpopulations of memory B-lymphocytes in the formation and persistence of the state of sensitization to a harmless allergen differs depending on the model system used or the clinical case under study. Therefore, drugs that target signaling pathways involved in the regulation of both plasma cells and memory B-lymphocytes are especially promising in the treatment of allergic diseases. The authors conclude that the components of the cellular response to oxidative stress and related genotoxic stress and ER stress are the most promising as such targets, since (a) all of them directly or indirectly affect the processes that regulate both of these subpopulations; b) are involved in the process of formation and maintenance of local allergic inflammation. The review presents data pointing to the particular promise of using nanoparticles of noble metals and complexes of rare earth metals of lanthanides in this regard, due to their ability to induce long-term effects in small doses due to changes in the properties of innate immunity cells and long-term accumulation in the body.
Introduction. Currently, there is a separate phenotype “bronchial asthma – obesity”, manifested by a more severe course of the disease, low rates of achieving asthma control, resistance to basic therapy. Asthma, like obesity, is recognized as a classic example of multifactorial diseases, which are based on a rather complex gene network. The active search for genetic markers characterizing individual characteristics of human metabolism continues. Of particular interest are the genes involved in the regulation of fat and carbohydrate metabolism.Aim. Analysis of associations of polymorphic loci Ala54Thr (G163A) of the FABP2 gene with bronchial asthma of varying severity and control of asthma in children.Materials and methods. 161 children with bronchial asthma in remission were examined by a continuous sampling method, of which 59 patients with obesity of 1-3 degrees without concomitant endocrine pathology. The examination included general clinical, functional, and instrumental methods. The level of asthma control was determined according to the GINA criteria (2018). The biochemical study was carried out on an automatic analyzer SAPPHIRE 400 (Japan). The study of gene polymorphisms was carried out by real-time polymerase chain reaction using sets of “Metabolism” (Research and Production Company “Litekh”, Moscow) on the CFX-96 Biorat device (USA).Results. We have not identified associations of the presence of polymorphic loci of the FABP2 gene with obesity. It was determined that in children with bronchial asthma, the frequency of carrying the homozygous genotype Thr/Thr and the minor allele Thr increased by 1.5 times compared to the control group (OR 9.043; 95%CI [2,093–39,073], p=0.0011 and OR 2.946; 95%CI [1,698‒5,111], p=0.001, respectively), and in children with bronchial asthma with and without asthma control, the carriage of the homozygous Thr/Thr genotype and the rare A allele increased the risk of uncontrolled bronchial asthma (OR 2.42; 95%CI [1.23‒4.79], p=0.03 and OR 1.75; 95%CI [1,119‒2,736], p=0.01), the frequency of the homozygous Ala/Ala genotype and the frequent Ala allele was detected 1.5 times more often in children with bronchial asthma associated with obesity (OR 2.176; 95%CI [1.001‒4.727], p=0.0008 and OR 2.378; 95%CI [1.495‒3.780], p=0.0002, respectively).Conclusion. Although we have not identified associations of the presence of polymorphic loci of the FABP2 gene with obesity, it has been shown that children with Ala54Thr+Thr54Тhr genotypes have significantly higher glucose levels (4.9±0.06 mmol/L compared with carriers of the Ala54Ala genotype 4.0±0.06 mmol/L, p<0.001), cholesterol (4.8±0.4 mmol/L compared with carriers of the Ala54Ala genotype 3.93±0.1 mmol/L, p<0.05) and low density lipoproteins (2.55±0.09 mmol/L compared with carriers of the Ala54Ala genotype 2.26±0.1 mmol/L, p<0.05). There is an obvious need for further investigation of the effect of gene polymorphism on the indicators of carbohydrate and lipid metabolism, depending on the nature of diets. These issues require further study as part of the search for probable cause-and-effect relationships and the creation of personalized programs depending on polymorphic gene variants.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.