Purpose of the study: to determine main parameters of the heart rhythm in children with type 1 diabetes, depending on the night level of glycemia. We performed bifunctional monitoring of glycemia and ECG in 50 patients with type 1 diabetes from 10 to 17 years. Depending on the glycemic parameters summarized in all patients we divided 3 groups: Group 1 (n=11) – sites of hypoglycemia (≤3.9 mmol/l), Group 2 (n=35) – optimal level of glycemia (4.0-9.0 mmol/l) and Group 3 (n=45) – sites of hyperglycemia (> 9 mmol/l). According to the results of glycemic monitoring, 96% of children do not have glycemic target marks at night and 20% of patients have asymptomatic night hypoglycemia. When analyzing the parameters of Holter ECG monitoring, the greatest value of heart rate, duration of the QTc interval, as well as atrial ectopic activity were often recorded during periods of hypoglycemia. Hyperglycemia also causes pathologic elongation of the ventricular electric systole and a greater number of ventricular extrasystoles. Thus, night hypo- and hyperglycemia in children and adolescents with type 1 diabetes leads to an extension of the QTc interval, an increase in the number of extrasystoles with the highest severity and frequency in hypoglycemia. We noted a high level of functioning of the sympathetic department of the autonomic nervous system and the central contour of heart rhythm regulation in children and adolescents with type 1 diabetes mellitus in hypoglycemia.
Смоленский государственный медицинский университет, Россия PecUliariTies oF DiaBeTes MelliTUs TYPe 1 in chilDren anD aDolescenTs againsT The BacKgroUnD oF connecTiVe TissUe DYsPlasia alimova i. l., Pashinskaja n. B., Pleskachevskaja T. a. smolensk state Medical University, russia Изучены особенности течения сахарного диабета 1 типа у 60 детей и подростков на фоне дисплазии соединительной ткани. Установлено, что у пациентов с дисплазией соединительной ткани диабетическая нейропатия и нефропатия формируются в более ранние сроки от начала заболевания и имеют более тяжелое течение. Таким образом, дети и подростки с дисплазией соединительной ткани относятся в группу риска по развитию осложнений сахарного диабета 1 типа. Ключевые слова: сахарный диабет, дети, дисплазии соединительной ткани Aim of the investigation was to study the peculiarities of diabetes mellitus type 1 in children and adolescents against the background of connective tissue dysplasia. Diabetic neuropathy and nephropathy developed at an earlier stage of the disease and have severe course in patients with diabetes mellitus and connective tissue dysplasia. Children and adolescents with connective tissue dysplasia thereby refer to the risk group for diabetes mellitus type 1 complications.
Генетическому разнообразию больных муковисцидозом (МВ) в России посвящены единичные работы на ограниченной выборке боль ных. Цель. Выявление особенностей генетического профиля больных МВ в России по данным Национального регистра (2014). Мате риалы и методы. Данные пациентов с МВ (n = 2 131) из 74 регионов России, включенные в Национальный регистр больных МВ (2014).
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