Objective:To identify the factors associated with intra-hospital neonatal mortality based on the individual characteristics of at-risk pregnant mothers, delivery and newborns. Method: This was a cross-sectional epidemiological study of live newborns delivered by women attended at the high-risk outpatient unit of a philanthropic hospital in Maringá, Paraná, Brazil between September 2012 and September 2013. Results: Six hundred and eighty-eight women participated in the study. The neonatal mortality coefficient found was 17.7/1,000 live births, most in the early neonatal phase. Premature labor, fetal malformation and multiple gestations were associated with neonatal death. Premature, very low birth weight newborns and those with an Apgar score of less than seven, five minutes after birth were at high risk of death. Conclusion: Identifying risk factors can help plan actions to consolidate the perinatal network. Specific programs should be incentivized in other countries, in the search for significant perinatal results such as reducing neonatal mortality. . If we break down infant mortality by age, worldwide, neonatal (0 to 27 days) deaths account for 44% of all deaths among children under the age of five (3) . In Brazil this component is even larger, and can be as high as 70% in all regions (2) , with 11.2 deaths per thousand live births between 2011 and 2012 (4) . In the state of Paraná, neonatal deaths dropped from 2,426 in 1996 to 1,279 in 2014 (94.8% less). However, in spite of all the progress made, 71.8% of infant deaths in 2014 were in the neonatal period (5) . According to the Report on Levels and Trends in Infant Mortality (Relatório de Níveis e Tendência em Mortalidade Infantil), the main goal is to reduce mortality in the neonatal period, which is where most infant deaths occur (1) . To reduce maternal and infant mortality, and the high percentage of avoidable deaths, in 2012 a public policy for prenatal care and for the care of newborns at risk was created in Paraná. It focuses on early detection of pregnant women at risk, their prenatal care, risk stratification of mothers and infants, specialized ambulatory care for pregnant women and infants (under the age of one) at risk, and ensured delivery via a system that is linked to the hospital (6) . Numerous studies have attempted to analyze the causes of neonatal deaths. Studies show a strong link between neonatal deaths and maternal and infant life conditions and health, economic situation, and access to healthcare, and to biological conditions such as gestational age, weight at birth and Apgar index (7) . We also call attention to the risk in the current and previous pregnancy (prior stillbirth, premature or low birth weight infants), the movement of the pregnant woman to delivery and women giving birth to low-weight babies (< 1,500 grams) in hospitals not equipped with a Neonatal Intensive Care Unit (NICU) (4) . Studies show that among newborns in NICU, Cesarean birth, failure to use steroids, pre-eclampsia, oligohydramnios, <2,500 grams ...