Far-reaching advances in the role of carbon nanotubes in cancer therapy

Dizaji, Babak Faraji; Khoshbakht, Saba; Farboudi, Amirnezam; Azarbaijan, Mohammadreza Hasani; Irani, Mohammad

doi:10.1016/j.lfs.2020.118059

Cited by 32 publications

(13 citation statements)

References 223 publications

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“…Targeted nano-drug delivery systems with small sizes (10 to 100 nm) enhance permeation through the newborn blood vessels of tumor tissues with slower clearance due to the lack of lymph 12 . These drug nanocarriers including micelles 13,14 , polymersomes 15 , liposomes 16 , dendrimers 17 , carbon nanotubes 18 , magnetic nanoparticles 19 and silica nanoparticles 20,21 are of high importance because of their higher permeability, detection of target cells, accumulation at cancer sites, less side effects, and more efficient treatment 4,5,22 .…”

Section: Introductionmentioning

confidence: 99%

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Baghbanbashi¹,

Pazuki²,

Khoee³

2021

Preprint

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Providing an efficient system for drug delivery and chemotherapy has always been an important issue. Modification of the surface of silica nanoparticles (SiO2) provides an opportunity for achieving stimulus-sensitive drug delivery system. Here, we have modified the surface of SiO2 using hydrogen bonding interactions by employing an aqueous two-phase system (ATPS) based on polyethylene glycol and lysine. This novel biocompatible ATPS provides an environment for simultaneous drug encapsulation, SiO2 modification, and drug partitioning in one pot. Addition of SiO2 to ATPS increased the partitioning of doxorubicin (DOX) as an anti-cancer drug from 47.92 in the absence of nanoparticles to 92.33 due to the interactions between drug and nanoparticles. The formation of nanoformulation and its characteristics were investigated applying microscopy, spectroscopy and thermal analysis. Drug release study demonstrated that DOX is loaded on nanoformulations efficiently with an encapsulation efficiency of 63.84% and shows lower release in physiological environment compared to the unmodified nanoparticles. While in acidic conditions of pH 5.5, significant increase was observed in the release profile. MTT assay on MCF-7 cancer cells confirmed that the nanoformulations were non-toxic and DOX-loaded nanocarrier showed anti-cancer behavior. These results indicate that the prepared nanoformulations are promising nanocarriers for controlled drug release purposes.

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Section: Introductionmentioning

confidence: 99%

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Baghbanbashi¹,

Pazuki²,

Khoee³

2021

Preprint

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“…In addition to these anatomopathological features of cancer, NPs are often functionalized with specific molecules to promote infiltration and retention within the TIME and cellular targeting ( Grobmyer and Moudgil, 2013 ; Nichols and Bae, 2014 ). Liposome ( Aronson et al, 2021 ), micelles ( Otsuka et al, 2003 ), gold nanoparticle ( Gerosa et al, 2020 ), carbon nanotubes ( Faraji Dizaji et al, 2020 ), silica/silicon NPs ( Adriani et al, 2012 ; van de Ven et al, 2012 ), nanorods ( Ali et al, 2017 ), dendrimers ( Huang et al, 2020 ), polymer NPs ( Avramovi et al, 2020 ) are some of the nanotechnologies most utilized for antitumor therapeutic strategies.…”

Section: Nanotechnologies For Therapeutic Deliverymentioning

confidence: 99%

Nanoparticle-Based Therapies for Turning Cold Tumors Hot: How to Treat an Immunosuppressive Tumor Microenvironment

Giustarini

Pavesi

Adriani

2021

Front. Bioeng. Biotechnol.

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Nanotechnologies are rapidly increasing their role in immuno-oncology in line with the need for novel therapeutic strategies to treat patients unresponsive to chemotherapies and immunotherapies. The tumor immune microenvironment (TIME) has emerged as critical for tumor classification and patient stratification to design better treatments. Notably, the tumor infiltration of effector T cells plays a crucial role in antitumor responses and has been identified as the primary parameter to define hot, immunosuppressed, excluded, and cold tumors. Organic and inorganic nanoparticles (NPs) have been applied as carriers of new targeted therapies to turn cold or altered (i.e., immunosuppressed or excluded) tumors into more therapeutically responsive hot tumors. This mini-review discusses the significant advances in NP-based approaches to turn immunologically cold tumors into hot ones.

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“…In this regard, nanocomposites can provide several suitable applications comprising synergistic effects because of the manifestation of distinct components, mixed at nanoscale. Carbon-based nanomaterials with their remarkable optical, electrical, thermal, biocompatibility, and chemical properties can be utilized for various important applications [ 75 ]. Further, diverse biorenewable resources can be utilized for fabricating these carbon-based nanomaterials, including vegetable oils, isolated bio-chemicals, plant biomasses, and animal bio-products.…”

Section: Trimetallic Nps/carbon Nanomaterials Composites With High mentioning

confidence: 99%

Trimetallic Nanoparticles: Greener Synthesis and Their Applications

et al. 2020

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Nanoparticles (NPs) and multifunctional nano-sized materials have significant applications in diverse fields, namely catalysis, sensors, optics, solar energy conversion, cancer therapy/diagnosis, and bioimaging. Trimetallic NPs have found unique catalytic, active food packaging, biomedical, antimicrobial, and sensing applications; they preserve an ever-superior level of catalytic activities and selectivity compared to monometallic and bimetallic nanomaterials. Due to these important applications, a variety of preparation routes, including hydrothermal, microemulsion, selective catalytic reduction, co-precipitation, and microwave-assisted methodologies have been reported for the syntheses of these nanomaterials. As the fabrication of nanomaterials using physicochemical methods often have hazardous and toxic impacts on the environment, there is a vital need to design innovative and well-organized eco-friendly, sustainable, and greener synthetic protocols for their assembly, by applying safer, renewable, and inexpensive materials. In this review, noteworthy recent advancements relating to the applications of trimetallic NPs and nanocomposites comprising these NPs are underscored as well as their eco-friendly and sustainable synthetic preparative options.

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Far-reaching advances in the role of carbon nanotubes in cancer therapy

Cited by 32 publications

References 223 publications

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Nanoparticle-Based Therapies for Turning Cold Tumors Hot: How to Treat an Immunosuppressive Tumor Microenvironment

Trimetallic Nanoparticles: Greener Synthesis and Their Applications

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