Factors Associated in the Aetiology of Peyronie's Disease

Abstract

In a retrospective study of 408 patients with Peyronie's disease 8 (1.9%) patients gave a positive family history for the condition. Sixty-three (15.4%) patients had a Dupuytren's contracture and trauma was considered to be an aetiological factor in 88 (21.5%) patients. One hundred and twenty-two (29.9%) patients had evidence of atherosclerosis and this is thought to be a factor in the pathogenesis of the disease. Peyronie's disease is not a single disease entity and is associated with many aetiological factors.

Epidemiology of Peyronie's disease

“…Additionally, we can confirm that diabetes seems to be a potential risk factor 8,10,19 as the share of diabetics with Peyronie's disease was three times greater (18.3 vs 6.0%).…”

“…It has been associated with a generalized fibrotic tendency, 21,22 and patients with this disorder have been reported to have an increased incidence of Depuytren's constructure (up to 48% reported in non-population-based studies) 23 In the Rochester study, only four patients (4%) had a diagnosis of Dupuytren's contracture. 14 Although Dupuytren's contracture is considered uncommon, in the absence of incidence rates for comparison, no conclusions can be drawn from these data.…”

“…21 Among our patients with Peyronie's disease, b-blocker use was uncommon before 1975. Based upon the comparison between bblocker use in the male population of Rochester and in patients with Peyronie's disease, the data suggest no association.…”

The association between Peyronie's and Dupuytren's disease

“…Previous reports concerning coexisting DD in patients presenting with PD show ranges varying from 0.01 to 58.8%, a positive family history for PD in 1-4% and a positive family history for DD in 9.8% (Table 2). 5,9,[14][15][16][17][18][19][20][21][22][23][24] The series from the UK, Italy, Australia and Serbia show the highest percentage of PD patients with coexisting DD. 9,15,17,19,24 The two reports focusing on PD patients o40 years show a lower percentage of coexisting DD.…”

“…13 The literature concerning coexisting DD in patients presenting with PD shows wide ranges varying from 0.01 to 58.8%. 5,9,[14][15][16][17][18][19][20][21][22][23][24] The aim of this study is to investigate the coexistence of DD in a consecutive series of patients with PD and their clinical characteristics, presenting at the outpatient urological clinic of the University Medical Centre Groningen, The Netherlands.…”