Disorders of Connective Tissue

Burrows, Nigel; Lovell, C. R.

doi:10.1002/9780470750520.ch46

Cited by 46 publications

(35 citation statements)

References 749 publications

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“…Atrophic wrinkled skin was seen in 63% (126) of patients in this study. The aged skin becomes fragile, translucent, lax and wrinkled [15]. Tindall and Smith [13] found an incidence of atrophic wrinkled skin in 94% patients.…”

Section: Discussionmentioning

confidence: 99%

A clinical study of geriatric dermatoses

Raveendra¹

2014

Our Dermatol Online

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Introduction:The geriatric population is composed of persons over 65 years of age and very few studies are available on the dermatologic diseases in this group. This study was done to study the spectrum of cutaneous manifestations and prevalence of physiological and pathological changes in the skin of elderly people. Material and Methods: Two hundred consecutive patients aged more than 65 years of age attending the outpatient clinic or admitted as inpatients in the Department of Dermatology at Vydehi Institute of Medical Sciences and Research Centre were subjects for the study. A detailed history of cutaneous complaints, present and past medical ailments was taken. A complete general physical, systemic examination and dermatological examination was done and all findings were noted in a pre designed proforma. Skin changes observed due to ageing were classified as physiological and pathological. Findings were collated in a master chart and results analyzed. Results: Out of 200 patients studied, 71% were males and 29% were females. Pruritus was the single most common complaint elicited (44%). Among the physiological changes, xerosis was the commonest (93%). Among the pathological changes skin tumours, eczemas, infections were the common findings. Conclusions:The geriatric dermatoses are different in different populations as some of the skin changes seen in western skin and Indian skin are not identical.

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Section: Discussionmentioning

confidence: 99%

A clinical study of geriatric dermatoses

Raveendra¹

2014

Our Dermatol Online

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“…1 Keloids clinically manifest as raised, hyper-pigmented, erythematous nodules or plaques, with an irregular border, making them visible and distinct from the surrounding skin. 2 Patients with darker skin have a higher prevalence for keloid than lighter skin.…”

Section: Introductionmentioning

confidence: 99%

A study of verapamil in treatment of keloid

et al. 2018

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Background: Keloid is a common presentation in clinical practice. Symptoms due to keloid are mild, but disfigurement and functional impairment can be severe. It is difficult to treat. Intralesional, injection triamcinolone acetonide, has limited efficacy, causes adverse effects such as local dermal atrophy, telengiectasia and hypopigmentation. Injection verapamil is reported to have similar efficacy, but lesser side effects, and is cheaper. Aim was to study efficacy and adverse effects of intralesional verapamil in treatment of keloid.Methods: An open label study on 25 patients of keloid, either gender, age 11 to 55 years at a medical college hospital. Injection verapamil 2.5 mg/ml was administered intralesionally, at an interval of 3 weeks, for a total of 6 sittings, over a period of 18 weeks. Vancouver scar scale (VSS) was used to assess the improvement. The statistical analysis was done using SPSS version 21.0.Results: Median duration of keloids was 8 months. The mean VSS score before treatment was 7.68 which reduced to 4.28 after treatment. Mean percentage change in VSS score was 46.21%, very highly significant (p<0.001). Physician’s assessment was ‘very good’ in 32.0% and 'excellent' in 8.0%. The complaint of post-procedure pain was present in almost all.Conclusions: Intralesional injection verapamil, gives very good to excellent improvement in 40% of patients of keloid. Post injection pain persists for more than 24 hours. Drug does not cause local dermal atrophy or hypopigmentation.

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“…DLE can be classified into (1) localized form (2) generalized form. [1,2] Genetic deficiencies of the complement components including C2, C3, C4, and C5 as well as the C1 esterase inhibitor are associated with DLE. Significant increases of human lymphocyte antigen (HLA) B7, B8, DR3, and DQA0102 and a significant decrease in HLA A2 have been reported for patients with DLE and A*03, B*07, DRB1*15 haplotype was associated with DLE.…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of white papules, central erythema, a border zone of irradiating white striae and peripheral telangiectasia are pathognomic. [1,2] Case Report A 19-year-old male patient, farmer by profession came with a chief complaint of painful ulcerations on his lower lip since 6 months [ Figure 1]. The pain was insidious in onset, localized throbbing to pricking type of pain which is of moderate intensity aggravates on taking food or trauma to that region.…”

Section: Introductionmentioning

confidence: 99%

Discoid lupus erythematosus at the vermilion border of the lip: A rare clinical presentation

Roy¹,

Shankarmurthy²

2015

JMRPS

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Discoid lupus erythematosus (DLE) is a chronic disease which affects the dermatome which causes scarring, hair loss, and hyperpigmentation changes in the skin. It has an effect on one's quality of life, due to its chronic course. Prognosis can be improved if treatment is initiated as early as possible. The condition can be diagnosed clinically, and histopathology may be required to confirm. DLE lesions turning into squamous cell carcinoma has been reported sparsely and due to inadequate data following the reporting of such lesion, this topic deserves attention. Here is an unusual case of DLE which was seen in a young male patient at the vermilion border of the lip.

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Disorders of Connective Tissue

Cited by 46 publications

References 749 publications

A clinical study of geriatric dermatoses

A clinical study of geriatric dermatoses

A study of verapamil in treatment of keloid

Discoid lupus erythematosus at the vermilion border of the lip: A rare clinical presentation

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