Etiopathogenesis of oral submucous fibrosis (OSF) is been studied for long time and still a fully satisfactory explanation is not obtained. Areca nut is the main etiological factor which is consumed as pan masala, gutka, mawa, and betel quid. It will interfere with the collegen synthesis and degradation causing the fibrosis. Several other etiological agents such as chilli and nutritional deficiency have been studied. Furthermore, the genetic susceptibility and autoimmune nature of disease have been postulated by some others. Current evidence also implicates collagen-related genes in the susceptibility and pathogenesis of OSF.
Discoid lupus erythematosus (DLE) is a chronic disease which affects the dermatome which causes scarring, hair loss, and hyperpigmentation changes in the skin. It has an effect on one's quality of life, due to its chronic course. Prognosis can be improved if treatment is initiated as early as possible. The condition can be diagnosed clinically, and histopathology may be required to confirm. DLE lesions turning into squamous cell carcinoma has been reported sparsely and due to inadequate data following the reporting of such lesion, this topic deserves attention. Here is an unusual case of DLE which was seen in a young male patient at the vermilion border of the lip.
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